Review Articles

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  • The NLRP3 inflammasome is a central operator in inflammation. Sharma and Kanneganti review the varied roles played by the NLRP3 inflammasome in cancer and metabolic diseases.

    • Bhesh Raj Sharma
    • Thirumala-Devi Kanneganti
    Review Article
  • Weyand and Goronzy discuss how the progressive loss of immune cell tolerance underlies the immunopathology associated with rheumatoid arthritis.

    • Cornelia M. Weyand
    • Jörg J. Goronzy
    Review Article
  • Terrando and colleagues review key mechanisms related to postoperative inflammation and the implications for developing perioperative neurocognitive disorders, with a focus on neuroinflammation and key cellular targets affected by surgical trauma.

    • Ting Yang
    • Ravikanth Velagapudi
    • Niccolò Terrando
    Review Article
  • Exposure to environmental pollutants can lead to immune system dysfunction with severe pathological consequences. Yamamoto and colleagues review the impact of pollutants on immune function and describe potential means to ameliorate these effects.

    • Takafumi Suzuki
    • Takanori Hidaka
    • Masayuki Yamamoto
    Review Article
  • Koliaraki, Prados, Armaka & Kollias review the roles of fibroblastic mesenchymal cells in tissue homeostasis and immunopathologic diseases, including chronic inflammatory disease, tissue fibrosis and cancer.

    • Vasiliki Koliaraki
    • Alejandro Prados
    • George Kollias
    Review Article
  • The RNA modification N6-methyladenosine (m6A) plays an essential role in the regulation of immunity. Here, Shulman and Stern-Ginossar review the roles of m6A in controlling immune recognition, activation of innate and adaptive immune responses, and cell fate decisions.

    • Ziv Shulman
    • Noam Stern-Ginossar
    Review Article
  • Turley and Krishnamurty review new insights into lymph node stromal cells, a heterogeneous cell population that serves distinct functions during development, in maintaining lymphocyte homeostasis, and in coordinating immune responses.

    • Akshay T. Krishnamurty
    • Shannon J. Turley
    Review Article
  • The cytokine IL-7 plays essential roles in lymphocyte development. In their Review, Barata, Durum and Seddon describe IL-7’s key homeostatic functions and how its dysregulation can lead to autoinflammatory disease and cancer.

    • João T. Barata
    • Scott K. Durum
    • Benedict Seddon
    Review Article
  • Ziegler and Corren review the cytokine TSLP, which regulates immune cell homeostasis at mucosal barriers, its role in allergic responses and newly discovered roles in cancer.

    • Jonathan Corren
    • Steven F. Ziegler
    Review Article
  • Xiaoxia Li and colleagues discuss the roles of signaling via IL-17 and its receptor and the implications of this axis for human health, noting their normal protective roles directed against fungi and bacteria as well as against pathological conditions in inflammation and cancer.

    • Xiaoxia Li
    • Rami Bechara
    • Sarah L. Gaffen
    Review Article