Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
In this Review, Kim et al. provide an overview of the prenatal immune conditions that contribute to the development of neurodevelopmental disorders and the immunological signatures and disorders associated with neurodevelopmental disorders.
Schäfer et al. discuss the application of computational methods that integrate single-cell and spatial multi-omics with existing biological knowledge to inform our understanding of immunological responses.
In this Review, Wilfahrt and Delgoffe discuss how T cells integrate nutrient sensing with activating stimuli to shape their differentiation and sensitivity to metabolites.
In this Review, Netea and colleagues summarize the latest research that contributes to our understanding of the pathophysiology of sepsis, and how this contributes to a new treatment approach through personalized immunotherapy.
In this Review, the authors describe the mechanisms that account for the generation and immune recognition of neoantigens that are not derived from DNA mutations, with a special focus on relevance to cancer and autoimmunity.
Bantug and Hess discuss the metabolic interplay between tumor-resident cells and how the effect of metabolism-targeted anticancer strategies on non-transformed or immune cells in the tumor needs to be considered.
Here the authors review CAR T cell engineering and immunotherapy for cancer and juxtapose state-of-the-art developments with CAR NK cells as part of our Cancer Immunology series of Reviews.
We are in the midst of an explosion of multiomics and spatial data along with constant innovation of the tools used to study these data. In this Review article, as part of our Cancer Immunology and Immunotherapy series, the authors discuss these innovations and their application to study the tumor microenvironment.
Proal and colleagues review the evidence for long-term persistence of coronavirus SARS-CoV-2 in tissues of infected individuals and discuss how this viral reservoir may contribute to the pathogenesis of post-acute sequelae of COVID-19 (PASC).
Fibrosis, defined by the excess deposition of structural and matricellular proteins in the extracellular space, underlies tissue dysfunction in multiple chronic diseases. Bhattacharya and Ramachandran provide a review of recent advances in our understanding of the immunology of human fibrosis.
Nimmerjahn and colleagues review posttranslational modification of immunoglobulins and how these posttranslational modifications influence antibody effector function. Furthermore, they discuss the implications of immunoglobulin posttranslational modifications when designing therapeutic antibodies for various clinical indications.
Buggert and colleagues provide a broad picture in this review of circulating and tissue-resident memory CD8+ T cells, which are ultimately responsible for effective immune surveillance.
Devant and Kagan review the biochemical and cell biological mechanisms that control gasdermin D pore-forming activity and its diverse downstream immunological effects.
In this Review, Künzli and Masopust provide updates on our understanding of the biology of memory CD4+ T cells as well as key technological advances that facilitate their characterization.
The adipose tissue is rich in immune cells. In this Review, the authors cover adipose tissue myeloid cells and how they control and respond to inflammation and pathology.
