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Despite enormous progress in basic research, there are many gaps in understanding human immunity. Here we describe how new investigational tools and computational methods promise to improve the diagnosis, prognosis and therapy of the many diseases with components from the immune system.
Chronic inflammatory diseases represent a major challenge for both clinical research and patient care, and evidence indicates that these disorders develop as a result of complex gene-environment interactions. Better understanding of their cause-and-effect relationship is the basis for emerging proposals for therapy and prevention.
Infections in infants continue to be an important cause of morbidity and mortality worldwide. Understanding the immune mechanisms that operate in infants is necessary for the development of new approaches to improve the health of infants around the world.
