Review Articles

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  • High-grade glioblastoma demonstrates exceedingly poor patient survival rates. In their Review, Lim and colleagues describe the immunological mechanisms involved in the control of glioblastoma and the outlook for immunotherapy.

    • Christopher M. Jackson
    • John Choi
    • Michael Lim
    Review Article
  • Pierce and colleagues discuss the cellular consequences of BCR signaling and recent advances in the understanding of B cell signaling in context in vivo.

    • Kihyuck Kwak
    • Munir Akkaya
    • Susan K. Pierce
    Review Article
  • Underlying inflammatory bowel disease is a complex web of activated immune cells. In this Review, Neurath delineates the cells, pathways and signals that contribute to the pathology of inflammatory bowel disease and the potential for therapeutic intervention.

    • Markus F. Neurath
    Review Article
  • In this Review, Pearce and colleagues discuss the metabolic adaptation of immune cells to various tissues and how functional adaptation compared with maladaptation within the niche can affect tissue homeostasis.

    • George Caputa
    • Angela Castoldi
    • Edward J. Pearce
    Review Article
  • In this Review, Natoli and Ostuni discuss the mechanisms of adaptation and memory in immunity, with the aim of providing basic concepts that rationalize the properties and molecular bases of these essential processes.

    • Gioacchino Natoli
    • Renato Ostuni
    Review Article
  • Comprehensive immunity requires that cells sense intracellular pathogens. In their Review, Shao and colleagues describe mechanisms for the recognition of intracellular lipopolysaccharide and its essential role in responses to Gram-negative bacteria.

    • Vijay A. K. Rathinam
    • Yue Zhao
    • Feng Shao
    Review Article
  • The skin and intestine are unique environments at the front line of the immune system. Powrie and colleagues review the distinctive adaptations acquired by regulatory T cells at these barrier surfaces.

    • Natasha Whibley
    • Andrea Tucci
    • Fiona Powrie
    Review Article
  • Screaton and colleagues discuss the role of the adaptive immune response against flaviviruses in protection and pathogenesis, with emphasis on cross-reactive T cell and antibody responses.

    • Jose Luis Slon Campos
    • Juthathip Mongkolsapaya
    • Gavin R. Screaton
    Review Article
  • Sok and Burton highlight recent developments in the discovery and application of antibodies able to neutralize diverse isolates of HIV, known as ‘broadly neutralizing antibodies’.

    • Devin Sok
    • Dennis R. Burton
    Review Article
  • Song and Colonna provide an overview of the common microglial response to neurodegeneration and discuss insights from mouse models and the study of human disease-associated genes.

    • Wilbur M. Song
    • Marco Colonna
    Review Article
  • He and Wang review the immunological functions of RIP kinases in inflammatory responses to microbial infection and tissue injury, as well as their potential roles in the pathogenesis of inflammatory disease and aging.

    • Sudan He
    • Xiaodong Wang
    Review Article
  • The immunoproteasome and thymoproteasome are specialized proteasomes operating within the immune system. In this Review, Murata et al. recount the discovery of the immunoproteasome and thymoproteasome and delve into their function, context in evolution and relation to human disease.

    • Shigeo Murata
    • Yousuke Takahama
    • Keiji Tanaka
    Review Article
  • Romagnani and colleagues discuss the specific recognition of viral antigens and peptides by NK cells and its implications for the composition of the NK cell repertoire and the selection of viral variants.

    • Quirin Hammer
    • Timo Rückert
    • Chiara Romagnani
    Review Article
  • The thymus has a critical role in the establishment of appropriately educated and self-tolerant T cells. In their Focus Review, Cheng and Anderson discuss the most recent insights into how the thymus establishes self-tolerance.

    • Mickie Cheng
    • Mark S. Anderson
    Review Article
  • Treg cells have a critical role in maintaining peripheral tolerance. In this Focus Review, Dominguez-Villar and Hafler describe how the instability and plasticity of Treg cells can contribute to the breakdown of tolerance and lead to autoimmune disease.

    • Margarita Dominguez-Villar
    • David A. Hafler
    Review Article
  • The rates of autoimmune disease are rising more rapidly than can be explained by changes in genetics. In this Focus Review, Verdu and Danska describe the dietary and microbial influences on type 1 diabetes and draw comparisons with celiac disease.

    • Elena F. Verdu
    • Jayne S. Danska
    Review Article