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Robert L. Coffman recounts how his work on immunoglobulin E regulation along with data from Tim Mosmann on the functional heterogeneity of T cell clones led to the T helper type 1–T helper type 2 hypothesis.
The stimulation of antigen-specific CD8+ T cells by the presentation of antigen acquired from outside the cell was the startling conclusion of Michael Bevan's work done more than 30 years ago.
Historical accounts of important experiments in Immunology provide insight and continuity to present areas of research. Jacques F.A.P. Miller inaugurates the Essay format with his seminal work on the thymus.
