Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Is a lifetime of sequential viral infections detrimental or advantageous to the host? New evidence suggests that pre-existing memory T cells specific for one type of virus can alter, for the better, the disease outcome after infection with an unrelated virus.
Regulation of the transcription factor Shn-2 by signals emanating from the TCR can distinguish positive from negative selection of developing thymocytes.
Viruses, such as CMV, have evolved a number of strategies with which to evade the immune system. Evidence is now emerging that murine CMV can also suppress the immune response by inducing functional paralysis of DCs.
The “two-signal” model proposes that immature DCs that deliver signal 1 in the absence of signal 2 cross-tolerize CD8+ T cells. New evidence shows that mature DCs are required for both cross-tolerance and cross-priming.
All kinases must be tightly regulated. Isolation of a novel molecule called IBtk identifies a potential mechanism for the regulation of Bruton's tyrosine kinase in B cells.