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Dolatshahi and Wessel use an in silico modeling approach to predict maternal–fetal IgG transfer selectivity and efficiency in utero that is needed for neonate protection against pathogens.
Some enhancers can limit their activities to specific spatial–temporal domains by enhancer suboptimization. Ou et al. find that classical dendritic cell (cDC) development depends on Irf8 suboptimization, which prevents unwanted IRF8 autoactivation in developing cDC2s while maximizing IRF8 expression in developed cDC1s.
Acute lung injury elicits a profibrotic wound healing program in monocyte-derived macrophages. Their abundance is associated with pulmonary fibrosis in individuals recovering from COVID-19 pneumonia.
The National Institute of Allergy and Infectious Diseases (NIAID) hosted a symposium on ‘AI and Immunology: Exploring Challenges and Opportunities’. The event considered how artificial intelligence (AI) can advance research on the multi-scale, adaptive immune system to improve human health, covering basic research and clinical use cases, data and AI model fundamentals.
Misharin, Sala and colleagues show that in patients with lung fibrosis after COVID-19, monocyte-derived alveolar macrophages activate an inflammatory and fibrotic program that was similar in patients with either resolving or progressing fibrosis.
TCF1+ progenitor-exhausted CD8+ T cell populations mediate durable antitumor immunity. Upon antigenic stimulation, effector T cells upregulate aerobic glycolysis to support their cytotoxic phenotype. Here, Mittal and colleagues find that loss of metabolic regulator PKM2 enriches for TCF1+ progenitor-exhausted-like cells and improves responsiveness to PD-1 blockade.
A novel method that recreates human intestinal organoids containing viable tissue-resident memory T cells will facilitate the exploration of tissue–immune interactions and clinically relevant immune pathologies.
