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c-MAF and BLIMP-1 inhibit pathobiont-induced colitis by common and distinct immune pathways
The intestinal immune response is tightly controlled to limit inflammation, largely by the cytokine IL-10, which prevents colitis. We report that the transcription factors c-MAF and BLIMP-1 induced IL-10 in T cells in the colon, but also acted to negatively regulate distinct cytokine pathways to restrict pathobiont-induced colitis.
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Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection
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SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC)
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Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease
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Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins