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  • IL-23 promotes tumor growth in preclinical cancer models and correlates with adverse clinical outcomes. Here, Becher and colleagues find that IL-23 produced by tumor-associated macrophages stabilizes Treg cell identity, promoting immunosuppression and tumor growth.

    • Tobias Wertheimer
    • Pascale Zwicky
    • Burkhard Becher
    ArticleOpen Access
  • Here, the authors characterize two distinct Treg cell populations in the visceral adipose tissue of lean and high-fat diet-fed mice. ST2+ Treg cells are dominant in male mice and are transcriptionally driven by GATA3 and PPARγ, regulators that limit the differentiation of the more female-dominant population of CXCR3+ Treg cells that are T-bet dependent. Functional distinctions are also evident in glucose tolerance and adipose inflammation.

    • Santiago Valle Torres
    • Kevin Man
    • Axel Kallies
  • Reis e Sousa et al. show that cDC2As and cDC2Bs are derived from distinct subsets of bone marrow pre-cDC2s, suggesting that the two lineages are ontogenetically determined.

    • Carlos M. Minutti
    • Cécile Piot
    • Caetano Reis e Sousa
    ArticleOpen Access
  • Here, the authors enhance their nasally delivered chimpanzee adenoviral-vectored SARS-CoV-2 vaccine with an Omicron-matched vaccine (ChAd-SARS-CoV-2-BA.5-S) that stimulates mucosal immunity in mice and hamsters and shows cross-reactive CD8+ memory T cell-driven protection against antigenically distant strains.

    • Baoling Ying
    • Tamarand L. Darling
    • Michael S. Diamond
    ArticleOpen Access

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