Focus on Adaptation

Latest Research

  • Review Article |

    Underlying inflammatory bowel disease is a complex web of activated immune cells. In this Review, Neurath delineates the cells, pathways and signals that contribute to the pathology of inflammatory bowel disease and the potential for therapeutic intervention.

    • Markus F. Neurath
  • Article |

    IFN-λ has important innate immune system functions at mucosal surfaces, but its importance in adaptive immunity is largely unknown. Using an influenza infection model, Gale and colleagues demonstrate that IFN-λ is essential for effective adaptive cellular immunity in the lung.

    • Emily A. Hemann
    • , Richard Green
    • , J. Bryan Turnbull
    • , Ryan A. Langlois
    • , Ram Savan
    •  & Michael Gale Jr
  • Article |

    Ginhoux and colleagues show that the priming of mouse hematopoietic progenitor cells toward the pDC lineage occurs at the common lymphoid progenitor stage.

    • Regine J. Dress
    • , Charles-Antoine Dutertre
    • , Amir Giladi
    • , Andreas Schlitzer
    • , Ivy Low
    • , Nurhidaya Binte Shadan
    • , Alicia Tay
    • , Josephine Lum
    • , Muhammad Faris Bin Mohd Kairi
    • , You Yi Hwang
    • , Etienne Becht
    • , Yang Cheng
    • , Marion Chevrier
    • , Anis Larbi
    • , Evan W. Newell
    • , Ido Amit
    • , Jinmiao Chen
    •  & Florent Ginhoux
  • Review Article |

    In this Review, Pearce and colleagues discuss the metabolic adaptation of immune cells to various tissues and how functional adaptation compared with maladaptation within the niche can affect tissue homeostasis.

    • George Caputa
    • , Angela Castoldi
    •  & Edward J. Pearce
  • Review Article |

    In this Review, Natoli and Ostuni discuss the mechanisms of adaptation and memory in immunity, with the aim of providing basic concepts that rationalize the properties and molecular bases of these essential processes.

    • Gioacchino Natoli
    •  & Renato Ostuni

News & Comment

Naturejobs.com

Nature events Directory