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  • NK cells require an immunological synapse to kill cancer cells and these synapses have been shown to have membranous protrusions. Here the authors use cutting-edge imaging and other techniques to show that tumor serine metabolism results in a reduction in NK cell sphingomyelin content and a lack of these membranous protrusions, which could contribute to a failure to kill cancer cells.

    • Xiaohu Zheng
    • Zhuanghao Hou
    • Haiming Wei
  • Singer and colleagues show that the developmental fate of autoreactive CD4+ thymocytes is determined by the timing and duration of agonist signaling. Early agonist signaling induces clonal deletion, whereas late agonist signaling induces differentiation into Foxp3+ Treg cells or IL-2+ Teff cells depending on whether TGF-β disrupts TCR signaling.

    • Xuguang Tai
    • Alyssa Indart
    • Alfred Singer
    Article Open Access
  • NLRP10 has been considered as an inflammasome inhibitor. Here the authors show that upon mitochondrial rupture, NLRP10 assembles a canonical inflammasome and is highly expressed in differentiated keratinocytes, possibly supporting skin homeostasis.

    • Tomasz Próchnicki
    • Matilde B. Vasconcelos
    • Eicke Latz
  • γδ T cells contribute to cancer immunity by killing tumor cells, but their function in the context of immune checkpoint inhibition is less clear. Here the authors show that a Vδ2 subset of γδ T cells in human kidney tumors phenotypically resembles exhausted T cells yet retains this cytolytic function and can be used to predict response to immune checkpoint inhibition.

    • Chiara Rancan
    • Marcel Arias-Badia
    • Lawrence Fong
    Article Open Access

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