• Stromal-immune cell interactions

    Please see the Nature Portfolio Collection on Stromal–Immune Cell Interactions. You will find recent research articles and reviews that discuss the players and factors involved in stromal–immune cell interactions in both health and disease.

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    Please see the Nature Portfolio Collection on Mentorship, presenting a series of commissioned World Views and Comments by authors who speak about how they view their roles as mentors and how to improve mentorship.

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    Nature Immunology has commissioned a Focus series of Reviews and Perspectives that discuss the innate and adaptive aspects of the immune response to SARS-CoV2, the possible mechanisms behind the large clinical variability in the response to infection, and considerations for vaccine and therapy strategies.

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  • APLAID is a rare autoinflammatory disorder driven by mutations in PLCG2. Here the authors provide a new mouse model using the human APLAID p.Ser707Tyr mutation. The mouse recapitulates clinical features of APLAID that can be prevented by anti-G-CSF. Individuals with APLAID were also shown to have high circulating levels of G-CSF suggesting this might be a suitable target for the clinic.

    • Elisabeth Mulazzani
    • Klara Kong
    • Seth L. Masters
    Article Open Access
  • NK cells require an immunological synapse to kill cancer cells and these synapses have been shown to have membranous protrusions. Here the authors use cutting-edge imaging and other techniques to show that tumor serine metabolism results in a reduction in NK cell sphingomyelin content and a lack of these membranous protrusions, which could contribute to a failure to kill cancer cells.

    • Xiaohu Zheng
    • Zhuanghao Hou
    • Haiming Wei
  • Singer and colleagues show that the developmental fate of autoreactive CD4+ thymocytes is determined by the timing and duration of agonist signaling. Early agonist signaling induces clonal deletion, whereas late agonist signaling induces differentiation into Foxp3+ Treg cells or IL-2+ Teff cells depending on whether TGF-β disrupts TCR signaling.

    • Xuguang Tai
    • Alyssa Indart
    • Alfred Singer
    Article Open Access
  • NLRP10 has been considered as an inflammasome inhibitor. Here the authors show that upon mitochondrial rupture, NLRP10 assembles a canonical inflammasome and is highly expressed in differentiated keratinocytes, possibly supporting skin homeostasis.

    • Tomasz Próchnicki
    • Matilde B. Vasconcelos
    • Eicke Latz

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