• Stromal-immune cell interactions

    Join us on Wednesday May 19th! We have invited a panel of experts to discuss their latest findings on stromal–immune cell interactions and insights on how intercellular communication occurs within the tissues. Register now!

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  • Tumor-associated macrophages (TAMs) play multifaceted roles in establishing an immunosuppressive tumor microenvironment. Sica and colleagues find that macrophage-intrinsic complement signaling initiates a pathway leading to the induction of highly tumorigenic TAMs.

    • Francesca Maria Consonni
    • Augusto Bleve
    • Antonio Sica
  • Fibroblastic reticular cells (FRCs) provide structural support and soluble factors necessary for proper lymph node organization and function. Turley and colleagues use scRNA-seq to identify a unique Gremlin1-expressing FRC subset that is found in T cell zones. Grem1+ FRCs support the survival of resident cDCs and are necessary to promote T cell immunity.

    • Varun N. Kapoor
    • Sören Müller
    • Shannon J. Turley
  • How microglia sense amyloid plaques in Alzheimer’s disease has remained mysterious. Lemke and colleagues report that TAM receptor kinases are absolutely required for normal microglial recognition of, response to and phagocytosis of Aβ plaques. Surprisingly, TAM-mediated microglial phagocytosis of Aβ material does not constrain, but rather promotes, the formation of dense-core plaques.

    • Youtong Huang
    • Kaisa E. Happonen
    • Greg Lemke
  • Sun and colleagues provide a new resource, multi-omics analysis of NK cell Jak–STAT signaling in response to the cytokines IL-2, IL-15, IL-12, IL-18 and IFN-α, showing synergistic and antagonistic interactions that govern NK cell activity.

    • Gabriela M. Wiedemann
    • Endi K. Santosa
    • Colleen M. Lau
    • Single-cell technologies reveal the building blocks of secondary lymphoid organs, identifying Grem1+ fibroblastic reticular cells (FRCs) as critical niche cells that contribute to resident dendritic cell homeostasis and T cell immunity.

      • Antonio P. Baptista
      • Michael Y. Gerner
      News & Views
    • A systems immunology analysis of controlled human malaria infections in Africans who were malaria experienced and Europeans who were malaria naive yields new insights into old questions of malaria immunity.

      • Prasida Holla
      • Tuan M. Tran
      News & Views
    • T cell responses probably play important roles in the control of SARS-CoV-2 infection, but they have been relatively understudied. Data now suggest that the majority of infected individuals develop robust and long-lasting T cell immunity, which has implications for the durability of immunity and future vaccine approaches.

      • Prasanna Jagannathan
      • Taia T. Wang
      News & Views
    • The TAM receptor kinases Axl and Mer are critical for microglial recognition and clearance of accumulating amyloid in transgenic models of Alzheimer’s disease.

      • Edward N. Wilson
      • Katrin I. Andreasson
      News & Views
    • HIV-1 infection of CD4+ T cells triggers the interaction of the mitochondrial proteins NLRX1 and FASTKD5 to promote oxidative phosphorylation, leading to increased viral replication. It has now been shown that this process can be blocked by metformin.

      • Emily A. Day
      • Luke A. J. O’Neill
      News & Views
  • Ulrich von Andrian recounts how an unexpected experimental result called into question a well-established concept in immunology: the mechanism of immune memory. Follow-up experiments revealed that NK cells can mediate antigen-specific adaptive immune responses.

    • Ulrich H. von Andrian
  • Taiwan has leveraged its experience in containing the 2003 SARS outbreak by responding to the COVID-19 crisis with rapid measures, early deployment, prudent actions and transparency. Collectively, these actions have created the ‘Taiwan model’ for combating COVID-19.

    • Shih-Chung Chen
    World View

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