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  • Dick and colleagues identify human LT-HSC subsets with distinct quiescent states. They link these differences to INKA1-mediated downregulation of the transmembrane protein CD112 and its interaction with the protein deacetylase SIRT1. INKA1 is inversely correlated with the histone H4K16Ac mark, which then distinguishes ‘latent’ CD112lo LT-HSCs from CD112hi LT-HSCs that are more readily activated in response to hematopoietic stress.

    • Kerstin B. Kaufmann
    • Andy G. X. Zeng
    • John E. Dick
    Article
  • Tumor-associated macrophages (TAMs) play multifaceted roles in establishing an immunosuppressive tumor microenvironment. Sica and colleagues find that macrophage-intrinsic complement signaling initiates a pathway leading to the induction of highly tumorigenic TAMs.

    • Francesca Maria Consonni
    • Augusto Bleve
    • Antonio Sica
    Article
  • Fibroblastic reticular cells (FRCs) provide structural support and soluble factors necessary for proper lymph node organization and function. Turley and colleagues use scRNA-seq to identify a unique Gremlin1-expressing FRC subset that is found in T cell zones. Grem1+ FRCs support the survival of resident cDCs and are necessary to promote T cell immunity.

    • Varun N. Kapoor
    • Sören Müller
    • Shannon J. Turley
    Article
    • In this Review, Mittelbrunn and Kroemer propose that ten molecular hallmarks represent the common denominators of T cell aging.

      • Maria Mittelbrunn
      • Guido Kroemer
      Review Article
    • As a follow up to a 2010 meeting deliberating on the benefits of studying mouse models of systemic lupus erythematosus (SLE), the virtual conference “Mouse models of lupus 10 years later” convened on 10 December 2020 to address a challenging decade that saw few new therapies approved, despite leaps in knowledge.

      • Erica Moore
      • Joshua A. Reynolds
      • Chaim Putterman
      Meeting Report
    • Single-cell technologies reveal the building blocks of secondary lymphoid organs, identifying Grem1+ fibroblastic reticular cells (FRCs) as critical niche cells that contribute to resident dendritic cell homeostasis and T cell immunity.

      • Antonio P. Baptista
      • Michael Y. Gerner
      News & Views
    • A systems immunology analysis of controlled human malaria infections in Africans who were malaria experienced and Europeans who were malaria naive yields new insights into old questions of malaria immunity.

      • Prasida Holla
      • Tuan M. Tran
      News & Views
    • T cell responses probably play important roles in the control of SARS-CoV-2 infection, but they have been relatively understudied. Data now suggest that the majority of infected individuals develop robust and long-lasting T cell immunity, which has implications for the durability of immunity and future vaccine approaches.

      • Prasanna Jagannathan
      • Taia T. Wang
      News & Views
  • Ulrich von Andrian recounts how an unexpected experimental result called into question a well-established concept in immunology: the mechanism of immune memory. Follow-up experiments revealed that NK cells can mediate antigen-specific adaptive immune responses.

    • Ulrich H. von Andrian
    Comment
  • Taiwan has leveraged its experience in containing the 2003 SARS outbreak by responding to the COVID-19 crisis with rapid measures, early deployment, prudent actions and transparency. Collectively, these actions have created the ‘Taiwan model’ for combating COVID-19.

    • Shih-Chung Chen
    World View

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