The immunoproteasome and thymoproteasome

Latest Research

  • Article |

    lncRNAs can regulate immune responses at a number of levels. Song and colleagues demonstrate that the lncRNA NKILA is expressed by tumor-associated cytotoxic T cells, and this predisposes them to activation-induced cell death and escape of tumors from immunologically mediated destruction.

    • Di Huang
    • , Jianing Chen
    • , Linbin Yang
    • , Qian Ouyang
    • , Jiaqian Li
    • , Liyan Lao
    • , Jinghua Zhao
    • , Jiang Liu
    • , Yiwen Lu
    • , Yue Xing
    • , Fei Chen
    • , Fengxi Su
    • , Herui Yao
    • , Qiang Liu
    • , Shicheng Su
    •  & Erwei Song
  • Article |

    Polić and colleagues show that the activating receptor NKG2D specifically sets the activation threshold for the activating receptor NCR1, providing a mechanism distinct from previously known mechanisms of NK cell education.

    • Vedrana Jelenčić
    • , Marko Šestan
    • , Inga Kavazović
    • , Maja Lenartić
    • , Sonja Marinović
    • , Tim D. Holmes
    • , Michaela Prchal-Murphy
    • , Berislav Lisnić
    • , Veronika Sexl
    • , Yenan T. Bryceson
    • , Felix M. Wensveen
    •  & Bojan Polić
  • Article |

    TH17 cells contribute to anti-fungal and anti-bacterial adaptive immune responses. Sallusto and colleagues show that the transcription factor c-Maf has an immunoregulatory role in directing gene expression and tissue residency in human IL-10+ TH17 cell subsets.

    • Dominik Aschenbrenner
    • , Mathilde Foglierini
    • , David Jarrossay
    • , Dan Hu
    • , Howard L. Weiner
    • , Vijay K. Kuchroo
    • , Antonio Lanzavecchia
    • , Samuele Notarbartolo
    •  & Federica Sallusto
  • Article |

    The receptor TLR3 is essential for effective responses to herpes simplex virus type 1. Miyake and colleagues demonstrate that a neuron- and astrocyte-intrinsic pathway of TLR3 and the metabolic checkpoint kinase complex mTORC2 is needed to prevent fulminant infection with this virus and encephalitis.

    • Ryota Sato
    • , Akihisa Kato
    • , Takahiko Chimura
    • , Shin-Ichiroh Saitoh
    • , Takuma Shibata
    • , Yusuke Murakami
    • , Ryutaro Fukui
    • , Kaiwen Liu
    • , Yun Zhang
    • , Jun Arii
    • , Ge-Hong Sun-Wada
    • , Yoh Wada
    • , Tsuneo Ikenoue
    • , Glen N. Barber
    • , Toshiya Manabe
    • , Yasushi Kawaguchi
    •  & Kensuke Miyake
  • Article |

    Locksley et al. show tissue-specific imprinting dictates the activating receptors ILC2s express, even in germ-free mice. Skin ILC2s are preferentially activated by IL-18, and IL-18 contributes to inflammation in a mouse model of atopic dermatitis.

    • Roberto R. Ricardo-Gonzalez
    • , Steven J. Van Dyken
    • , Christoph Schneider
    • , Jinwoo Lee
    • , Jesse C. Nussbaum
    • , Hong-Erh Liang
    • , Dedeepya Vaka
    • , Walter L. Eckalbar
    • , Ari B. Molofsky
    • , David J. Erle
    •  & Richard M. Locksley

News & Comment

  • News & Views |

    Studies of mice demonstrate a link between the female hormone estrogen and protection against bacteremia and sepsis through the induction of natural antibodies to Eshcerichia coli.

    • Joseph Chavarria-Smith
    • , Wouter L. W. Hazenbos
    •  & Menno van Lookeren Campagne
  • News & Views |

    Cell-type-specific regulation of gene expression by transcription factors is a fundamental principle of biology. New findings show that microRNA-mediated control of target-gene expression is also dependent on the cellular context.

    • Pengda Chen
    • , Kunyu Liao
    •  & Changchun Xiao
  • News & Views |

    New insights into how NK cells are educated by the receptor NKG2D, which leads to effects on another receptor, NCR1, raise interesting questions about why so many receptors are linked to the education of NK cells.

    • André Veillette
    •  & Yan Lu
  • News & Views |

    Group 2 innate lymphoid cells (ILC2s) that produce the cytokine IL-5 are found in lung, gut, fat and skin tissues. New findings indicate that ILC2s in different tissues selectively express distinct functional cytokine receptors for cell activation in response to the local environment.

    • Jinfang Zhu

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