AhR-driven IL-10 production

Latest Research

  • Article |

    TCR signaling initiates a signaling cascade involving the kinases Lck and Zap70 and the adaptor LAT. Weiss and colleagues discover a proline-rich motif in LAT, which facilitates interactions among Lck, LAT and Zap70 for efficient TCR signaling.

    • Wan-Lin Lo
    • , Neel H. Shah
    • , Nagib Ahsan
    • , Veronika Horkova
    • , Ondrej Stepanek
    • , Arthur R. Salomon
    • , John Kuriyan
    •  & Arthur Weiss
  • Article |

    The cytokines IL-17A and IL-17F bind via same receptor. Iwakura and colleagues demonstrate different functions for IL-17A and IL-17F in the gut, with the latter altering the production of antimicrobial peptides with consequent effects on the microbiota, the induction of Treg cells and immune-system homeostasis.

    • Ce Tang
    • , Shigeru Kakuta
    • , Kenji Shimizu
    • , Motohiko Kadoki
    • , Tomonori Kamiya
    • , Tomoyuki Shimazu
    • , Sachiko Kubo
    • , Shinobu Saijo
    • , Harumichi Ishigame
    • , Susumu Nakae
    •  & Yoichiro Iwakura
  • Article |

    TIGIT is a co-inhibitory receptor associated with T cell exhaustion. Tian and colleagues demonstrate that TIGIT is the predominant inhibitory receptor on NK cells in both humans and mice and that its blockade enhances NK cell–dependent rejection of tumors in experimental models.

    • Qing Zhang
    • , Jiacheng Bi
    • , Xiaodong Zheng
    • , Yongyan Chen
    • , Hua Wang
    • , Wenyong Wu
    • , Zhengguang Wang
    • , Qiang Wu
    • , Hui Peng
    • , Haiming Wei
    • , Rui Sun
    •  & Zhigang Tian
  • Resource |

    The immune response to pathogens varies substantially among humans. Netea and colleagues show that integration of multi-omics data and deep phenotyping enables prediction of cytokine production in responses to pathogens.

    • Olivier B. Bakker
    • , Raul Aguirre-Gamboa
    • , Serena Sanna
    • , Marije Oosting
    • , Sanne P. Smeekens
    • , Martin Jaeger
    • , Maria Zorro
    • , Urmo Võsa
    • , Sebo Withoff
    • , Romana T. Netea-Maier
    • , Hans J. P. M. Koenen
    • , Irma Joosten
    • , Ramnik J. Xavier
    • , Lude Franke
    • , Leo A. B. Joosten
    • , Vinod Kumar
    • , Cisca Wijmenga
    • , Mihai G. Netea
    •  & Yang Li
  • Article |

    Semaphorins play well-known roles in axon guidance. Kumanogoh and colleagues demonstrate that Semaphorin 6D cell-intrinsically activates anti-inflammatory macrophage polarization.

    • Sujin Kang
    • , Yoshimitsu Nakanishi
    • , Yoshiyuki Kioi
    • , Daisuke Okuzaki
    • , Tetsuya Kimura
    • , Hyota Takamatsu
    • , Shohei Koyama
    • , Satoshi Nojima
    • , Masayuki Nishide
    • , Yoshitomo Hayama
    • , Yuhei Kinehara
    • , Yasuhiro Kato
    • , Takeshi Nakatani
    • , Tomomi Shimogori
    • , Junichi Takagi
    • , Toshihiko Toyofuku
    •  & Atsushi Kumanogoh
  • Technical Report |

    Isolating tissue-resident cells runs the risk of altering their expression profile. Jung and colleagues use a RiboTagging approach to describe the microglial translatome and demonstrate that macrophage extraction from their tissue environment results in significant transcriptional alterations.

    • Zhana Haimon
    • , Alon Volaski
    • , Johannes Orthgiess
    • , Sigalit Boura-Halfon
    • , Diana Varol
    • , Anat Shemer
    • , Simon Yona
    • , Binyamin Zuckerman
    • , Eyal David
    • , Louise Chappell-Maor
    • , Ingo Bechmann
    • , Martin Gericke
    • , Igor Ulitsky
    •  & Steffen Jung

News & Comment

  • News & Views |

    The cytokine IL-17F constrains the growth of immunoregulatory Clostridium cluster XIVa species and represents a potential therapeutic target for the treatment of inflammatory bowel disease.

    • Aisling O’Hara Hall
    • , Jennifer E. Towne
    •  & Scott E. Plevy
  • News & Views |

    Tumor-associated natural killer cells have elevated expression of the checkpoint inhibitory receptor TIGIT. Monoclonal antibody–mediated blockade targeting TIGIT unleashes the anti-tumor activity of both natural killer cells and T cells in preclinical mouse models and efficiently delays tumor growth.

    • Ana Stojanovic
    •  & Adelheid Cerwenka
  • News & Views |

    The metabolic master regulator mTORC1 is shown to promote alternative macrophage activation via Semaphorin 6D reverse signaling and reprogramming of lipid metabolism.

    • Jayne Louise Wilson
    •  & Thomas Weichhart
  • News & Views |

    Analysis of whole-blood transcriptional profiles in adults hospitalized with influenza reveals time- and severity-related gene-expression signatures.

    • David F. Tough

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