alleles restrict TCR hypervariable regions
HLA alleles influence the amino acid compositions of T cell receptors (TCRs). The DNA ‘yarn’ has different HLA alleles, represented by different colors, which create the TCR ‘knit’. The red HLA allele is the risk allele that increases pathogenic TCRs, damaging the surrounding knit. Ishigaki et al. developed a statistical approach to map and quantify the HLA genetic control over TCRs.
See Ishigaki et al.