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Volume 53 Issue 8, August 2021

Volume 53 Issue 8

Chromatin neighborhoods

This cartoon depicts a genomic ‘neighborhood’ with houses and apartments representing genes. The mailbox ‘promoters’ and mRNA mailtruck are all wired into a complex network of cis-regulatory elements depicted as power plants, lighting each of the homes to different levels. A new approach called HCR–FlowFISHallows researchers to use CRISPR to perturb these elements, quantifying and mapping how they connect to genes.

See Reilly et al.

Image: SciStories LLC. Cover Design: Valentina Monaco.



  • Obituary |

    Stephen T. Warren was a key contributor to the 1991 discovery of an unstable trinucleotide repeat that expands in families and causes loss of function in fragile X syndrome.

    • David L. Nelson

Research Highlights

News & Views

  • News & Views |

    Genome-wide association studies have identified genetic variants in maternal and fetal genomes associated with early-life growth traits but have been limited by the paucity of large-scale family-based cohorts that would enable the resolution of informative transmissions between parents and their offspring. A new study uses extensive pedigree data from the Icelandic population to identify genetic effects on birth weight that differ according to parental origin and to demarcate distinct contributions from the maternal intrauterine environment and offspring genetics on fetal growth.

    • David M. Evans
    • Rachel M. Freathy
  • News & Views |

    Metastable epialleles refer to loci with variable methylation states among individuals without underlying genetic differences. Although these loci have generally been assumed to be vulnerable to environmental influence, a new study reports their remarkable metastable epigenetic robustness toward a range of physiological, chemical and dietary disruptions in mammals.

    • Deborah Bourc’his



Amendments & Corrections


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