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Volume 53 Issue 5, May 2021

Volume 53 Issue 5

Dinoflagellate endosymbionts of cauliflower coral

The image shows a fluorescence microscopy close-up of polyps of the cauliflower coral Stylophora pistillata and their dinoflagellate endosymbionts. The coral host exhibits green fluorescence due to natural GFP expression, and the symbiotic Symbiodinium microadriaticum dinoflagellates are visible because of their red fluorescence from excited chlorophyll.

See Nand et al.

Image: Eric Tambutté, Centre Scientifique de Monaco. Cover Design: Valentina Monaco.

News & Views

  • News & Views |

    The nucleosome remodeling and deacetylase (NuRD) complex is a chromatin modifier with a key role in the switch from fetal to adult hemoglobin. In a new study, Vinjamur et al. identify a fetal hemoglobin repressor, ZNF410, which does not directly bind the γ-globin promoter but acts through highly specific regulation of CHD4, a protein subunit of the NuRD complex, thus presenting a potential approach for therapeutic reactivation of fetal hemoglobin.

    • Laxminath Tumburu
    • Swee Lay Thein
  • News & Views |

    RNA is dynamic and can fold into multiple alternative conformations. A new study shows that cells control mRNA translation by regulating the stoichiometry of alternative RNA structures formed from extremely conserved sequences of 5′ untranslated regions and that this control may contribute to embryonic development.

    • Amit Gupta
    • Jean-Denis Beaudoin
  • News & Views |

    Cells resembling human fetal adrenal neuroblasts have been identified as major neuroblastoma cancer cells through single-cell mRNA comparison. Tumor risk stratification correlates with the differentiation of neuroblast-like neuroblastoma cells.

    • Hermann Rohrer


  • Perspective |

    This Perspective on crop genomics discusses the promises of new technologies and approaches to help minimize food insecurity and to lay the foundation for sustainable agricultural systems needed to feed the world.

    • Michael D. Purugganan
    • Scott A. Jackson
  • Perspective |

    Recent technologies allow experimental manipulation of chromatin conformation. This Perspective discusses the insights obtained from gain-of-function studies that engineer the three-dimensional genome.

    • Di Zhang
    • Jessica Lam
    • Gerd A. Blobel



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