Volume 53 Issue 2, February 2021

Genome-wide analyses identify multiple loci associated with hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM) and left ventricular (LV) traits. Cardiomyopathies exhibit strong genetic correlations with LV traits, with opposing effects in HCM and DCM.

Genome-wide association analyses identify 12 susceptibility loci for hypertrophic cardiomyopathy (HCM). A genetic risk score for HCM was associated with disease status in a validation study and influenced phenotypic severity in carriers of risk variants in sarcomere genes.

Integrating human brain proteomes with genome-wide association data followed by Mendelian randomization identifies 11 genes with potentially causal roles in Alzheimer’s disease pathogenesis.

Genome-wide association analysis of 8,956 German individuals identifies 38 genetic loci associated with single bacteria and overall microbiome composition.

Analysis of human genotypes and 16S microbiome data of 18,473 individuals from 25 cohorts through a genome-wide association study, a phenome-wide association study and Mendelian randomization identifies host genetic and microbial trait associations.

Genome-wide analysis of RNA-binding protein (RBP) target sites identifies a major role for RBP dysregulation in complex psychiatric disorders and implicates DDHD2 as a candidate risk gene for schizophrenia.

Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in individuals of European and African ancestry provide insights into its relationship with anxiety and depressive disorders and identify potential candidates for drug repositioning.

Genetic analysis of 35 blood and urine laboratory measurements from 363,228 individuals identifies 1,857 loci associated with at least one laboratory value.

Tractor is a statistical framework that facilitates the inclusion of admixed individuals in association studies by leveraging local ancestry. Tractor generates accurate ancestry-specific effect-size estimates and improves the resolution of association signals.

A short isoform of the SARS-CoV-2 host receptor ACE2, expressed in human nasal and bronchial respiratory epithelia, is upregulated in response to interferon treatment and rhinovirus infection, but not SARS-CoV-2 infection.

Stat3 depletion in pluripotent cells decreases α-ketoglutarate and increases the expression of Otx2 and its targets Dnmt3a and Dnmt3b, leading to global DNA hypermethylation.

DIS3 deficiency alters CTCF and cohesin binding at the Igh locus in B cells. These cells show decreased class-switch recombination but increased chromosomal translocations.

A comprehensive rice quantitative trait nucleotide map provides new genetic insights and serves as the basis for RiceNavi, a tool to optimize breeding schemes.