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Volume 51 Issue 8, August 2019

Volume 51 Issue 8

Uncoupling TAD structure from gene expression

The mountains represent wild-type topologically associating domains (TADs), and the reflection in the water below depicts the rearranged TADs present on Drosophila balancer chromosomes. Although there are many changes in topology (the landscape), these have little effect on gene expression.

See Ghavi-Helm et al.

Image: Artwork by Beata Edyta Mierzwa. Cover Design: Erin Dewalt.

Editorial

  • Editorial |

    Record high temperatures are being seen worldwide, thus placing strains on human health and disrupting the availability of essential resources such as food and water. Aberrant weather patterns in the form of intense storms or prolonged drought have put pressure on our agricultural systems and underscored the need for adaptation to a changing climate across many sectors. Complex problems require complex solutions, and genetic approaches could be a powerful tool for helping to mitigate the effects of climate change.

Correspondence

News & Views

  • News & Views |

    Chromatin loops and domains are major organizational hallmarks of chromosomes. New work suggests, however, that these topological features of the genome are poor global predictors of gene activity, raising questions about their function.

    • Elizabeth H. Finn
    • Tom Misteli

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