Volume 50 Issue 12, December 2018

Volume 50 Issue 12

Lymphoma invading the skin

Deficiency in TIM-3 immune checkpoint induces the formation of subcutaneous panniculitis-like T cell lymphoma (SPTCL), a rare skin lymphoma subtype with characteristics of autoimmune inflammation. SPTCL is restricted largely to the adipose layer under the skin without lymph node involvement. Here cytotoxic lymphocytes are seen surrounding the adipocytes they target.

See Gayden et al.

Image: Bertsy Goic (www.instagram.com/drawinscience). Cover Design: Erin Dewalt.

Editorial

  • Editorial |

    Well-designed science education via social media may help to reach a larger group of audiences with the aim of reducing the boundaries between researchers and the public. This may, in turn, move basic science toward translational improvement in human health and agriculture.

Correspondence

News & Views

  • News & Views |

    A new study identifies loss-of-function mutations in HAVCR2, which encodes TIM-3, in patients with a rare cutaneous T cell lymphoma associated with aberrant immunological activation. These mutations lead to loss of the TIM-3 immunological checkpoint, thus promoting inflammation and malignancy.

    • Karen O. Dixon
    • , Madhumita Das
    •  & Vijay K. Kuchroo

Perspectives

  • Perspective |

    Mitochondrial variants are important to consider when analyzing the genetics of various metabolic or age-related diseases. These mtDNA variants can influence the penetrance of a phenotype or interact differentially with nuclear DNA variants.

    • Douglas C. Wallace

Letters

  • Letter |

    This study finds germline loss-of-function mutations in HAVCR2, which encodes the immune modulator TIM-3, in individuals with subcutaneous panniculitis-like T cell lymphomas and hemophagocytic lymphohistiocytosis, a life-threatening inflammatory condition.

    • Tenzin Gayden
    • , Fernando E. Sepulveda
    • , Dong-Anh Khuong-Quang
    • , Jonathan Pratt
    • , Elvis T. Valera
    • , Alexandrine Garrigue
    • , Susan Kelso
    • , Frank Sicheri
    • , Leonie G. Mikael
    • , Nancy Hamel
    • , Andrea Bajic
    • , Rola Dali
    • , Shriya Deshmukh
    • , Dzana Dervovic
    • , Daniel Schramek
    • , Frédéric Guerin
    • , Mikko Taipale
    • , Hamid Nikbakht
    • , Jacek Majewski
    • , Despina Moshous
    • , Janie Charlebois
    • , Sharon Abish
    • , Christine Bole-Feysot
    • , Patrick Nitschke
    • , Brigitte Bader-Meunier
    • , David Mitchell
    • , Catherine Thieblemont
    • , Maxime Battistella
    • , Simon Gravel
    • , Van-Hung Nguyen
    • , Rachel Conyers
    • , Jean-Sebastien Diana
    • , Chris McCormack
    • , H. Miles Prince
    • , Marianne Besnard
    • , Stephane Blanche
    • , Paul G. Ekert
    • , Sylvie Fraitag
    • , William D. Foulkes
    • , Alain Fischer
    • , Bénédicte Neven
    • , David Michonneau
    • , Geneviève de Saint Basile
    •  & Nada Jabado
  • Letter |

    Retinoic acid and BMP4 signaling, together with p63, contribute to dynamic long-range chromatin interactions during keratinocyte differentiation. TP63 decreases chromatin accessibility and promotes H3K27me3 accumulation at enhancers.

    • Jillian M. Pattison
    • , Sandra P. Melo
    • , Samantha N. Piekos
    • , Jessica L. Torkelson
    • , Elizaveta Bashkirova
    • , Maxwell R. Mumbach
    • , Charlotte Rajasingh
    • , Hanson Hui Zhen
    • , Lingjie Li
    • , Eric Liaw
    • , Daniel Alber
    • , Adam J. Rubin
    • , Gautam Shankar
    • , Xiaomin Bao
    • , Howard Y. Chang
    • , Paul A. Khavari
    •  & Anthony E. Oro
  • Letter |

    In zebrafish, cilia-driven flow of cerebrospinal fluid transports adrenergic signals that induce urotensin neuropeptides in spinal cord neurons. In turn, these neuropeptides activate their receptor on nearby muscle fibers, straightening the body axis.

    • Xiaoli Zhang
    • , Shuo Jia
    • , Zhe Chen
    • , Yan Ling Chong
    • , Haibo Xie
    • , Dong Feng
    • , Xiaotong Wu
    • , Don Zhu Song
    • , Sudipto Roy
    •  & Chengtian Zhao
  • Letter |

    Analysis of 1,007 sibling pairs from 251 families identifies 878 de novo mutations shared by siblings at 448 sites. Recurrence probability based on parental somatic mosaicism, sibling sharing, parent of origin, mutation type and genomic position can range from 0.011% to 28.5%.

    • Hákon Jónsson
    • , Patrick Sulem
    • , Gudny A. Arnadottir
    • , Gunnar Pálsson
    • , Hannes P. Eggertsson
    • , Snaedis Kristmundsdottir
    • , Florian Zink
    • , Birte Kehr
    • , Kristjan E. Hjorleifsson
    • , Brynjar Ö. Jensson
    • , Ingileif Jonsdottir
    • , Sigurdur Einar Marelsson
    • , Sigurjon Axel Gudjonsson
    • , Arnaldur Gylfason
    • , Adalbjorg Jonasdottir
    • , Aslaug Jonasdottir
    • , Simon N. Stacey
    • , Olafur Th. Magnusson
    • , Unnur Thorsteinsdottir
    • , Gisli Masson
    • , Augustine Kong
    • , Bjarni V. Halldorsson
    • , Agnar Helgason
    • , Daniel F. Gudbjartsson
    •  & Kari Stefansson
  • Letter |

    Genome-wide association meta-analysis of data sets from Iceland and the UK identifies 16 new risk loci for osteoarthritis, including missense variants in SMO, IL11, and COL11A1.

    • Unnur Styrkarsdottir
    • , Sigrun H. Lund
    • , Gudmar Thorleifsson
    • , Florian Zink
    • , Olafur A. Stefansson
    • , Jon K. Sigurdsson
    • , Kristinn Juliusson
    • , Kristbjörg Bjarnadottir
    • , Sara Sigurbjornsdottir
    • , Stefan Jonsson
    • , Kristjan Norland
    • , Lilja Stefansdottir
    • , Asgeir Sigurdsson
    • , Gardar Sveinbjornsson
    • , Asmundur Oddsson
    • , Gyda Bjornsdottir
    • , Reynir L. Gudmundsson
    • , Gisli H. Halldorsson
    • , Thorunn Rafnar
    • , Ingileif Jonsdottir
    • , Eirikur Steingrimsson
    • , Gudmundur L. Norddahl
    • , Gisli Masson
    • , Patrick Sulem
    • , Helgi Jonsson
    • , Thorvaldur Ingvarsson
    • , Daniel F. Gudbjartsson
    • , Unnur Thorsteinsdottir
    •  & Kari Stefansson

Articles

  • Article | | Open Access

    De novo assembly of 23 Aspergillus section Nigri and 6 Aspergillus niger genome sequences allows for inter- and intraspecies comparisons and prediction of secondary metabolite gene clusters.

    • Tammi C. Vesth
    • , Jane L. Nybo
    • , Sebastian Theobald
    • , Jens C. Frisvad
    • , Thomas O. Larsen
    • , Kristian F. Nielsen
    • , Jakob B. Hoof
    • , Julian Brandl
    • , Asaf Salamov
    • , Robert Riley
    • , John M. Gladden
    • , Pallavi Phatale
    • , Morten T. Nielsen
    • , Ellen K. Lyhne
    • , Martin E. Kogle
    • , Kimchi Strasser
    • , Erin McDonnell
    • , Kerrie Barry
    • , Alicia Clum
    • , Cindy Chen
    • , Kurt LaButti
    • , Sajeet Haridas
    • , Matt Nolan
    • , Laura Sandor
    • , Alan Kuo
    • , Anna Lipzen
    • , Matthieu Hainaut
    • , Elodie Drula
    • , Adrian Tsang
    • , Jon K. Magnuson
    • , Bernard Henrissat
    • , Ad Wiebenga
    • , Blake A. Simmons
    • , Miia R. Mäkelä
    • , Ronald P. de Vries
    • , Igor V. Grigoriev
    • , Uffe H. Mortensen
    • , Scott E. Baker
    •  & Mikael R. Andersen
  • Article |

    Whole-genome sequencing of 175 Mongolians representing six tribes highlights population-specific genetic architecture and substantial gene flow among northern Eurasian populations, including derived alleles shared by Mongolians and Finns.

    • Haihua Bai
    • , Xiaosen Guo
    • , Narisu Narisu
    • , Tianming Lan
    • , Qizhu Wu
    • , Yanping Xing
    • , Yong Zhang
    • , Stephen R. Bond
    • , Zhili Pei
    • , Yanru Zhang
    • , Dandan Zhang
    • , Jirimutu Jirimutu
    • , Dong Zhang
    • , Xukui Yang
    • , Morigenbatu Morigenbatu
    • , Li Zhang
    • , Bingyi Ding
    • , Baozhu Guan
    • , Junwei Cao
    • , Haorong Lu
    • , Yiyi Liu
    • , Wangsheng Li
    • , Ningxin Dang
    • , Mingyang Jiang
    • , Shenyuan Wang
    • , Huixin Xu
    • , Dingzhu Wang
    • , Chunxia Liu
    • , Xin Luo
    • , Ying Gao
    • , Xueqiong Li
    • , Zongze Wu
    • , Liqing Yang
    • , Fanhua Meng
    • , Xiaolian Ning
    • , Hashenqimuge Hashenqimuge
    • , Kaifeng Wu
    • , Bo Wang
    • , Suyalatu Suyalatu
    • , Yingchun Liu
    • , Chen Ye
    • , Huiguang Wu
    • , Kalle Leppälä
    • , Lu Li
    • , Lin Fang
    • , Yujie Chen
    • , Wenhao Xu
    • , Tao Li
    • , Xin Liu
    • , Xun Xu
    • , Christopher R. Gignoux
    • , Huanming Yang
    • , Lawrence C. Brody
    • , Jun Wang
    • , Karsten Kristiansen
    • , Burenbatu Burenbatu
    • , Huanmin Zhou
    •  & Ye Yin
  • Article |

    Targeted inactivation, restoration and overexpression of MALAT1 in multiple in vivo models demonstrate that the lncRNA MALAT1 suppresses breast cancer metastasis through binding and inactivation of the pro-metastatic transcription factor TEAD.

    • Jongchan Kim
    • , Hai-Long Piao
    • , Beom-Jun Kim
    • , Fan Yao
    • , Zhenbo Han
    • , Yumeng Wang
    • , Zhenna Xiao
    • , Ashley N. Siverly
    • , Sarah E. Lawhon
    • , Baochau N. Ton
    • , Hyemin Lee
    • , Zhicheng Zhou
    • , Boyi Gan
    • , Shinichi Nakagawa
    • , Matthew J. Ellis
    • , Han Liang
    • , Mien-Chie Hung
    • , M. James You
    • , Yutong Sun
    •  & Li Ma
  • Article |

    Eight genome-wide CRISPR screens identify genes required for substrate-specific phagocytosis. The study highlights roles for NHLRC2 in filopodia formation, very-long-chain fatty acids in substrate-specific phagocytosis and TM2D3 in uptake of amyloid-β aggregates.

    • Michael S. Haney
    • , Christopher J. Bohlen
    • , David W. Morgens
    • , James A. Ousey
    • , Amira A. Barkal
    • , C. Kimberly Tsui
    • , Braeden K. Ego
    • , Roni Levin
    • , Roarke A. Kamber
    • , Hannah Collins
    • , Andrew Tucker
    • , Amy Li
    • , Daan Vorselen
    • , Lorenzo Labitigan
    • , Emily Crane
    • , Evan Boyle
    • , Lihua Jiang
    • , Joanne Chan
    • , Esther Rincón
    • , William J. Greenleaf
    • , Billy Li
    • , Michael P. Snyder
    • , Irving L. Weissman
    • , Julie A. Theriot
    • , Sean R. Collins
    • , Ben A. Barres
    •  & Michael C. Bassik

Technical Reports

  • Technical Report |

    A machine learning approach for refinement of somatic variant calls automates this process and reduces bias stemming from inter-reviewer variability.

    • Benjamin J. Ainscough
    • , Erica K. Barnell
    • , Peter Ronning
    • , Katie M. Campbell
    • , Alex H. Wagner
    • , Todd A. Fehniger
    • , Gavin P. Dunn
    • , Ravindra Uppaluri
    • , Ramaswamy Govindan
    • , Thomas E. Rohan
    • , Malachi Griffith
    • , Elaine R. Mardis
    • , S. Joshua Swamidass
    •  & Obi L. Griffith
  • Technical Report |

    Tri-C is a new 3C approach to identify concurrent chromatin interactions at individual alleles. The authors observe specific higher-order structures involving simultaneous interactions between multiple enhancers and promoters, called regulatory hubs.

    • A. Marieke Oudelaar
    • , James O. J. Davies
    • , Lars L. P. Hanssen
    • , Jelena M. Telenius
    • , Ron Schwessinger
    • , Yu Liu
    • , Jill M. Brown
    • , Damien J. Downes
    • , Andrea M. Chiariello
    • , Simona Bianco
    • , Mario Nicodemi
    • , Veronica J. Buckle
    • , Job Dekker
    • , Douglas R. Higgs
    •  & Jim R. Hughes

Amendments & Corrections

  • Author Correction |

    • Valentina Iotchkova
    • , Jie Huang
    • , John A Morris
    • , Deepti Jain
    • , Caterina Barbieri
    • , Klaudia Walter
    • , Josine L Min
    • , Lu Chen
    • , William Astle
    • , Massimilian Cocca
    • , Patrick Deelen
    • , Heather Elding
    • , Aliki-Eleni Farmaki
    • , Christopher S Franklin
    • , Mattias Franberg
    • , Tom R Gaunt
    • , Albert Hofman
    • , Tao Jiang
    • , Marcus E Kleber
    • , Genevieve Lachance
    • , Jian’an Luan
    • , Giovanni Malerba
    • , Angela Matchan
    • , Daniel Mead
    • , Yasin Memari
    • , Ioanna Ntalla
    • , Kalliope Panoutsopoulou
    • , Raha Pazoki
    • , John R B Perry
    • , Fernando Rivadeneira
    • , Maria Sabater-Lleal
    • , Bengt Sennblad
    • , So-Youn Shin
    • , Lorraine Southam
    • , Michela Traglia
    • , Freerk van Dijk
    • , Elisabeth M van Leeuwen
    • , Gianluigi Zaza
    • , Weihua Zhang
    • , Najaf Amin
    • , Adam Butterworth
    • , John C Chambers
    • , George Dedoussis
    • , Abbas Dehghan
    • , Oscar H Franco
    • , Lude Franke
    • , Mattia Frontini
    • , Giovanni Gambaro
    • , Paolo Gasparini
    • , Anders Hamsten
    • , Aaron Isaacs
    • , Jaspal S Kooner
    • , Charles Kooperberg
    • , Claudia Langenberg
    • , Winfried Marz
    • , Robert A Scott
    • , Morris A Swertz
    • , Daniela Toniolo
    • , Andre G Uitterlinden
    • , Cornelia M van Duijn
    • , Hugh Watkins
    • , Eleftheria Zeggini
    • , Mathew T Maurano
    • , Nicholas J Timpson
    • , Alexander P Reiner
    • , Paul L Auer
    •  & Nicole Soranzo
  • Publisher Correction |

    • Jisen Zhang
    • , Xingtan Zhang
    • , Haibao Tang
    • , Qing Zhang
    • , Xiuting Hua
    • , Xiaokai Ma
    • , Fan Zhu
    • , Tyler Jones
    • , Xinguang Zhu
    • , John Bowers
    • , Ching Man Wai
    • , Chunfang Zheng
    • , Yan Shi
    • , Shuai Chen
    • , Xiuming Xu
    • , Jingjing Yue
    • , David R. Nelson
    • , Lixian Huang
    • , Zhen Li
    • , Huimin Xu
    • , Dong Zhou
    • , Yongjun Wang
    • , Weichang Hu
    • , Jishan Lin
    • , Youjin Deng
    • , Neha Pandey
    • , Melina Mancini
    • , Dessireé Zerpa
    • , Julie K. Nguyen
    • , Liming Wang
    • , Liang Yu
    • , Yinghui Xin
    • , Liangfa Ge
    • , Jie Arro
    • , Jennifer O. Han
    • , Setu Chakrabarty
    • , Marija Pushko
    • , Wenping Zhang
    • , Yanhong Ma
    • , Panpan Ma
    • , Mingju Lv
    • , Faming Chen
    • , Guangyong Zheng
    • , Jingsheng Xu
    • , Zhenhui Yang
    • , Fang Deng
    • , Xuequn Chen
    • , Zhenyang Liao
    • , Xunxiao Zhang
    • , Zhicong Lin
    • , Hai Lin
    • , Hansong Yan
    • , Zheng Kuang
    • , Weimin Zhong
    • , Pingping Liang
    • , Guofeng Wang
    • , Yuan Yuan
    • , Jiaxian Shi
    • , Jinxiang Hou
    • , Jingxian Lin
    • , Jingjing Jin
    • , Peijian Cao
    • , Qiaochu Shen
    • , Qing Jiang
    • , Ping Zhou
    • , Yaying Ma
    • , Xiaodan Zhang
    • , Rongrong Xu
    • , Juan Liu
    • , Yongmei Zhou
    • , Haifeng Jia
    • , Qing Ma
    • , Rui Qi
    • , Zhiliang Zhang
    • , Jingping Fang
    • , Hongkun Fang
    • , Jinjin Song
    • , Mengjuan Wang
    • , Guangrui Dong
    • , Gang Wang
    • , Zheng Chen
    • , Teng Ma
    • , Hong Liu
    • , Singha R. Dhungana
    • , Sarah E. Huss
    • , Xiping Yang
    • , Anupma Sharma
    • , Jhon H. Trujillo
    • , Maria C. Martinez
    • , Matthew Hudson
    • , John J. Riascos
    • , Mary Schuler
    • , Li-Qing Chen
    • , David M. Braun
    • , Lei Li
    • , Qingyi Yu
    • , Jianping Wang
    • , Kai Wang
    • , Michael C. Schatz
    • , David Heckerman
    • , Marie-Anne Van Sluys
    • , Glaucia Mendes Souza
    • , Paul H. Moore
    • , David Sankoff
    • , Robert VanBuren
    • , Andrew H. Paterson
    • , Chifumi Nagai
    •  & Ray Ming
  • Publisher Correction |

    • Evangelos Evangelou
    • , Helen R. Warren
    • , David Mosen-Ansorena
    • , Borbala Mifsud
    • , Raha Pazoki
    • , He Gao
    • , Georgios Ntritsos
    • , Niki Dimou
    • , Claudia P. Cabrera
    • , Ibrahim Karaman
    • , Fu Liang Ng
    • , Marina Evangelou
    • , Katarzyna Witkowska
    • , Evan Tzanis
    • , Jacklyn N. Hellwege
    • , Ayush Giri
    • , Digna R. Velez Edwards
    • , Yan V. Sun
    • , Kelly Cho
    • , J. Michael Gaziano
    • , Peter W. F. Wilson
    • , Philip S. Tsao
    • , Csaba P. Kovesdy
    • , Tonu Esko
    • , Reedik Mägi
    • , Lili Milani
    • , Peter Almgren
    • , Thibaud Boutin
    • , Stéphanie Debette
    • , Jun Ding
    • , Franco Giulianini
    • , Elizabeth G. Holliday
    • , Anne U. Jackson
    • , Ruifang Li-Gao
    • , Wei-Yu Lin
    • , Jian’an Luan
    • , Massimo Mangino
    • , Christopher Oldmeadow
    • , Bram Peter Prins
    • , Yong Qian
    • , Muralidharan Sargurupremraj
    • , Nabi Shah
    • , Praveen Surendran
    • , Sébastien Thériault
    • , Niek Verweij
    • , Sara M. Willems
    • , Jing-Hua Zhao
    • , Philippe Amouyel
    • , John Connell
    • , Renée de Mutsert
    • , Alex S. F. Doney
    • , Martin Farrall
    • , Cristina Menni
    • , Andrew D. Morris
    • , Raymond Noordam
    • , Guillaume Paré
    • , Neil R. Poulter
    • , Denis C. Shields
    • , Alice Stanton
    • , Simon Thom
    • , Gonçalo Abecasis
    • , Najaf Amin
    • , Dan E. Arking
    • , Kristin L. Ayers
    • , Caterina M. Barbieri
    • , Chiara Batini
    • , Joshua C. Bis
    • , Tineka Blake
    • , Murielle Bochud
    • , Michael Boehnke
    • , Eric Boerwinkle
    • , Dorret I. Boomsma
    • , Erwin P. Bottinger
    • , Peter S. Braund
    • , Marco Brumat
    • , Archie Campbell
    • , Harry Campbell
    • , Aravinda Chakravarti
    • , John C. Chambers
    • , Ganesh Chauhan
    • , Marina Ciullo
    • , Massimiliano Cocca
    • , Francis Collins
    • , Heather J. Cordell
    • , Gail Davies
    • , Martin H. de Borst
    • , Eco J. de Geus
    • , Ian J. Deary
    • , Joris Deelen
    • , Fabiola Del Greco M.
    • , Cumhur Yusuf Demirkale
    • , Marcus Dörr
    • , Georg B. Ehret
    • , Roberto Elosua
    • , Stefan Enroth
    • , A. Mesut Erzurumluoglu
    • , Teresa Ferreira
    • , Mattias Frånberg
    • , Oscar H. Franco
    • , Ilaria Gandin
    • , Paolo Gasparini
    • , Vilmantas Giedraitis
    • , Christian Gieger
    • , Giorgia Girotto
    • , Anuj Goel
    • , Alan J. Gow
    • , Vilmundur Gudnason
    • , Xiuqing Guo
    • , Ulf Gyllensten
    • , Anders Hamsten
    • , Tamara B. Harris
    • , Sarah E. Harris
    • , Catharina A. Hartman
    • , Aki S. Havulinna
    • , Andrew A. Hicks
    • , Edith Hofer
    • , Albert Hofman
    • , Jouke-Jan Hottenga
    • , Jennifer E. Huffman
    • , Shih-Jen Hwang
    • , Erik Ingelsson
    • , Alan James
    • , Rick Jansen
    • , Marjo-Riitta Jarvelin
    • , Roby Joehanes
    • , Åsa Johansson
    • , Andrew D. Johnson
    • , Peter K. Joshi
    • , Pekka Jousilahti
    • , J. Wouter Jukema
    • , Antti Jula
    • , Mika Kähönen
    • , Sekar Kathiresan
    • , Bernard D. Keavney
    • , Kay-Tee Khaw
    • , Paul Knekt
    • , Joanne Knight
    • , Ivana Kolcic
    • , Jaspal S. Kooner
    • , Seppo Koskinen
    • , Kati Kristiansson
    • , Zoltan Kutalik
    • , Maris Laan
    • , Marty Larson
    • , Lenore J. Launer
    • , Benjamin Lehne
    • , Terho Lehtimäki
    • , David C. M. Liewald
    • , Li Lin
    • , Lars Lind
    • , Cecilia M. Lindgren
    • , YongMei Liu
    • , Ruth J. F. Loos
    • , Lorna M. Lopez
    • , Yingchang Lu
    • , Leo-Pekka Lyytikäinen
    • , Anubha Mahajan
    • , Chrysovalanto Mamasoula
    • , Jaume Marrugat
    • , Jonathan Marten
    • , Yuri Milaneschi
    • , Anna Morgan
    • , Andrew P. Morris
    • , Alanna C. Morrison
    • , Peter J. Munson
    • , Mike A. Nalls
    • , Priyanka Nandakumar
    • , Christopher P. Nelson
    • , Teemu Niiranen
    • , Ilja M. Nolte
    • , Teresa Nutile
    • , Albertine J. Oldehinkel
    • , Ben A. Oostra
    • , Paul F. O’Reilly
    • , Elin Org
    • , Sandosh Padmanabhan
    • , Walter Palmas
    • , Aarno Palotie
    • , Alison Pattie
    • , Brenda W. J. H. Penninx
    • , Markus Perola
    • , Annette Peters
    • , Ozren Polasek
    • , Peter P. Pramstaller
    • , Quang Tri Nguyen
    • , Olli T. Raitakari
    • , Meixia Ren
    • , Rainer Rettig
    • , Kenneth Rice
    • , Paul M. Ridker
    • , Janina S. Ried
    • , Harriëtte Riese
    • , Samuli Ripatti
    • , Antonietta Robino
    • , Lynda M. Rose
    • , Jerome I. Rotter
    • , Igor Rudan
    • , Daniela Ruggiero
    • , Yasaman Saba
    • , Cinzia F. Sala
    • , Veikko Salomaa
    • , Nilesh J. Samani
    • , Antti-Pekka Sarin
    • , Reinhold Schmidt
    • , Helena Schmidt
    • , Nick Shrine
    • , David Siscovick
    • , Albert V. Smith
    • , Harold Snieder
    • , Siim Sõber
    • , Rossella Sorice
    • , John M. Starr
    • , David J. Stott
    • , David P. Strachan
    • , Rona J. Strawbridge
    • , Johan Sundström
    • , Morris A. Swertz
    • , Kent D. Taylor
    • , Alexander Teumer
    • , Martin D. Tobin
    • , Maciej Tomaszewski
    • , Daniela Toniolo
    • , Michela Traglia
    • , Stella Trompet
    • , Jaakko Tuomilehto
    • , Christophe Tzourio
    • , André G. Uitterlinden
    • , Ahmad Vaez
    • , Peter J. van der Most
    • , Cornelia M. van Duijn
    • , Anne-Claire Vergnaud
    • , Germaine C. Verwoert
    • , Veronique Vitart
    • , Uwe Völker
    • , Peter Vollenweider
    • , Dragana Vuckovic
    • , Hugh Watkins
    • , Sarah H. Wild
    • , Gonneke Willemsen
    • , James F. Wilson
    • , Alan F. Wright
    • , Jie Yao
    • , Tatijana Zemunik
    • , Weihua Zhang
    • , John R. Attia
    • , Adam S. Butterworth
    • , Daniel I. Chasman
    • , David Conen
    • , Francesco Cucca
    • , John Danesh
    • , Caroline Hayward
    • , Joanna M. M. Howson
    • , Markku Laakso
    • , Edward G. Lakatta
    • , Claudia Langenberg
    • , Olle Melander
    • , Dennis O. Mook-Kanamori
    • , Colin N. A. Palmer
    • , Lorenz Risch
    • , Robert A. Scott
    • , Rodney J. Scott
    • , Peter Sever
    • , Tim D. Spector
    • , Pim van der Harst
    • , Nicholas J. Wareham
    • , Eleftheria Zeggini
    • , Daniel Levy
    • , Patricia B. Munroe
    • , Christopher Newton-Cheh
    • , Morris J. Brown
    • , Andres Metspalu
    • , Adriana M. Hung
    • , Christopher J. O’Donnell
    • , Todd L. Edwards
    • , Bruce M. Psaty
    • , Ioanna Tzoulaki
    • , Michael R. Barnes
    • , Louise V. Wain
    • , Paul Elliott
    •  & Mark J. Caulfield