Volume 49 Issue 8, August 2017

Volume 49 Issue 8

Cover image by Erin Dewalt (see p 1282)

Editorial

  • Editorial |

    This month's research articles span the range of scales of gene-regulatory mechanisms, from a deceptively simple gene therapy vector, via synthetic gene expression circuits, to extremely intricate epigenetic switches. We encourage investigation of synthetic circuits exploring the functions of the 3D genome.

News and Views

  • News & Views |

    Severe allergic disease is common, and few monogenic causes of atopy have been described. A new study that convincingly links severe atopic dermatitis to heterozygous CARD11 mutations with dominant-interfering activity serves as a timely reminder that clinicians should consider the possibility of an underlying monogenic immune disorder when caring for patients suffering from severe allergic disease.

    • Catherine M Biggs
    • , Henry Y Lu
    •  & Stuart E Turvey
  • News & Views |

    DNA copy number represents an essential parameter in the dynamics of synthetic gene circuits but typically is not explicitly considered. A new study demonstrates how dynamic control of DNA copy number can serve as an effective strategy to program robust oscillations in gene expression circuits.

    • Feilun Wu
    •  & Lingchong You
  • News & Views |

    A new study reports molecular characterization of the GDF5 locus, which is associated with osteoarthritis risk and adult height in humans. This study provides evidence of positive selection for short stature at GDF5 in modern humans, as well as in archaic Neandertals and Denisovans.

    • Guillaume Lettre

Analysis

  • Analysis |

    Jeffrey Barrett, Tarjinder Singh and colleagues present a meta-analysis of rare coding variants and copy number variants in a large collection of schizophrenia cases and controls, combined with de novo mutation data from family trios. They find that rare, damaging variants contribute to risk of schizophrenia both with and without intellectual disability and that there is overlap between genetic risk for schizophrenia and other neurodevelopmental disorders.

    • Tarjinder Singh
    • , James T R Walters
    • , Mandy Johnstone
    • , David Curtis
    • , Jaana Suvisaari
    • , Minna Torniainen
    • , Elliott Rees
    • , Conrad Iyegbe
    • , Douglas Blackwood
    • , Andrew M McIntosh
    • , Georg Kirov
    • , Daniel Geschwind
    • , Robin M Murray
    • , Marta Di Forti
    • , Elvira Bramon
    • , Michael Gandal
    • , Christina M Hultman
    • , Pamela Sklar
    • , INTERVAL Study
    • , UK10K Consortium
    • , Aarno Palotie
    • , Patrick F Sullivan
    • , Michael C O'Donovan
    • , Michael J Owen
    •  & Jeffrey C Barrett
  • Analysis |

    Matthew Robinson, Peter Visscher and colleagues use phenotypic data on 172,000 sibling pairs and phenotypic and SNP data on 150,832 unrelated individuals to estimate the heritability of body mass index across a range of experimental designs. They conclude that substantially larger sample sizes across ages and lifestyle factors will be required to understand the full genetic architecture of this trait.

    • Matthew R Robinson
    • , Geoffrey English
    • , Gerhard Moser
    • , Luke R Lloyd-Jones
    • , Marcus A Triplett
    • , Zhihong Zhu
    • , Ilja M Nolte
    • , Jana V van Vliet-Ostaptchouk
    • , Harold Snieder
    • , The LifeLines Cohort Study
    • , Tonu Esko
    • , Lili Milani
    • , Reedik Mägi
    • , Andres Metspalu
    • , Patrik K E Magnusson
    • , Nancy L Pedersen
    • , Erik Ingelsson
    • , Magnus Johannesson
    • , Jian Yang
    • , David Cesarini
    •  & Peter M Visscher

Articles

  • Article |

    Ingileif Jonsdottir, Björn Nilsson, Kari Stefansson and colleagues perform a genome-wide association study for immunoglobulin levels in Icelandic and Swedish cohorts. They find 38 new variants associated with IgA, IgG, IgM or composite immunoglobulin traits and identify candidate genes underlying the regulation of immunoglobulin levels.

    • Stefan Jonsson
    • , Gardar Sveinbjornsson
    • , Aitzkoa Lopez de Lapuente Portilla
    • , Bhairavi Swaminathan
    • , Rosina Plomp
    • , Gillian Dekkers
    • , Ram Ajore
    • , Mina Ali
    • , Arthur E H Bentlage
    • , Evelina Elmér
    • , Gudmundur I Eyjolfsson
    • , Sigurjon A Gudjonsson
    • , Urban Gullberg
    • , Arnaldur Gylfason
    • , Bjarni V Halldorsson
    • , Markus Hansson
    • , Hilma Holm
    • , Åsa Johansson
    • , Ellinor Johnsson
    • , Aslaug Jonasdottir
    • , Bjorn R Ludviksson
    • , Asmundur Oddsson
    • , Isleifur Olafsson
    • , Sigurgeir Olafsson
    • , Olof Sigurdardottir
    • , Asgeir Sigurdsson
    • , Lilja Stefansdottir
    • , Gisli Masson
    • , Patrick Sulem
    • , Manfred Wuhrer
    • , Anna-Karin Wihlborg
    • , Gudmar Thorleifsson
    • , Daniel F Gudbjartsson
    • , Unnur Thorsteinsdottir
    • , Gestur Vidarsson
    • , Ingileif Jonsdottir
    • , Björn Nilsson
    •  & Kari Stefansson
  • Article |

    Erwin Gelfand, Andrew Snow, Joshua Milner and colleagues identify heterozygous CARD11 mutations associated with severe atopic disease in eight individuals from four families. They further show that the mutant CARD11 proteins exhibit both loss-of-function and dominant-interfering activity and that the cellular defects in patient T cells can be partially rescued by supplementing with glutamine.

    • Chi A Ma
    • , Jeffrey R Stinson
    • , Yuan Zhang
    • , Jordan K Abbott
    • , Michael A Weinreich
    • , Pia J Hauk
    • , Paul R Reynolds
    • , Jonathan J Lyons
    • , Celeste G Nelson
    • , Elisa Ruffo
    • , Batsukh Dorjbal
    • , Salomé Glauzy
    • , Natsuko Yamakawa
    • , Swadhinya Arjunaraja
    • , Kelsey Voss
    • , Jennifer Stoddard
    • , Julie Niemela
    • , Yu Zhang
    • , Sergio D Rosenzweig
    • , Joshua J McElwee
    • , Thomas DiMaggio
    • , Helen F Matthews
    • , Nina Jones
    • , Kelly D Stone
    • , Alejandro Palma
    • , Matías Oleastro
    • , Emma Prieto
    • , Andrea R Bernasconi
    • , Geronimo Dubra
    • , Silvia Danielian
    • , Jonathan Zaiat
    • , Marcelo A Marti
    • , Brian Kim
    • , Megan A Cooper
    • , Neil Romberg
    • , Eric Meffre
    • , Erwin W Gelfand
    • , Andrew L Snow
    •  & Joshua D Milner
  • Article |

    Terence Capellini, David Kingsley and colleagues use transgenic mice to show that a Gdf5 enhancer (termed GROW1) is required for normal bone length. They suggest that a common variant at the human GROW1 enhancer was under selection in human populations and also contributes to arthritis susceptibility.

    • Terence D Capellini
    • , Hao Chen
    • , Jiaxue Cao
    • , Andrew C Doxey
    • , Ata M Kiapour
    • , Michael Schoor
    •  & David M Kingsley
  • Article |

    Charles Mullighan, Stephen Hunger, Jinghui Zhang and colleagues report a genomic analysis of 264 pediatric and young adult T-lineage acute lymphoblastic leukemia (T-ALL) samples. They identify 106 candidate driver genes, 53 of which have not been described previously in pediatric T-ALL, as well as associations between mutations and disease stage or subtype.

    • Yu Liu
    • , John Easton
    • , Ying Shao
    • , Jamie Maciaszek
    • , Zhaoming Wang
    • , Mark R Wilkinson
    • , Kelly McCastlain
    • , Michael Edmonson
    • , Stanley B Pounds
    • , Lei Shi
    • , Xin Zhou
    • , Xiaotu Ma
    • , Edgar Sioson
    • , Yongjin Li
    • , Michael Rusch
    • , Pankaj Gupta
    • , Deqing Pei
    • , Cheng Cheng
    • , Malcolm A Smith
    • , Jaime Guidry Auvil
    • , Daniela S Gerhard
    • , Mary V Relling
    • , Naomi J Winick
    • , Andrew J Carroll
    • , Nyla A Heerema
    • , Elizabeth Raetz
    • , Meenakshi Devidas
    • , Cheryl L Willman
    • , Richard C Harvey
    • , William L Carroll
    • , Kimberly P Dunsmore
    • , Stuart S Winter
    • , Brent L Wood
    • , Brian P Sorrentino
    • , James R Downing
    • , Mignon L Loh
    • , Stephen P Hunger
    • , Jinghui Zhang
    •  & Charles G Mullighan
  • Article |

    Jos Jonkers, Lodewyk Wessels and colleagues use a Sleeping Beauty transposon mutagenesis screen to identify genes required for invasive lobular breast carcinoma formation (ILC) in mice. They find recurrent and mutually exclusive insertions in Myh9, Ppp1r12a, Ppp1r12b and Trp53bp2, which are implicated in the actin cytoskeleton regulation pathway and have been found to be altered in human ILC breast cancer.

    • Sjors M Kas
    • , Julian R de Ruiter
    • , Koen Schipper
    • , Stefano Annunziato
    • , Eva Schut
    • , Sjoerd Klarenbeek
    • , Anne Paulien Drenth
    • , Eline van der Burg
    • , Christiaan Klijn
    • , Jelle J ten Hoeve
    • , David J Adams
    • , Marco J Koudijs
    • , Jelle Wesseling
    • , Micha Nethe
    • , Lodewyk F A Wessels
    •  & Jos Jonkers
  • Article |

    Damian Smedley and colleagues report the phenotypic characterization of the first 3,328 genes by the International Mouse Phenotyping Consortium. They develop new mouse models based on genes known to be associated with human mendelian diseases and identify potential disease-associated genes with little or no previous functional annotation.

    • Terrence F Meehan
    • , Nathalie Conte
    • , David B West
    • , Julius O Jacobsen
    • , Jeremy Mason
    • , Jonathan Warren
    • , Chao-Kung Chen
    • , Ilinca Tudose
    • , Mike Relac
    • , Peter Matthews
    • , Natasha Karp
    • , Luis Santos
    • , Tanja Fiegel
    • , Natalie Ring
    • , Henrik Westerberg
    • , Simon Greenaway
    • , Duncan Sneddon
    • , Hugh Morgan
    • , Gemma F Codner
    • , Michelle E Stewart
    • , James Brown
    • , Neil Horner
    • , The International Mouse Phenotyping Consortium
    • , Melissa Haendel
    • , Nicole Washington
    • , Christopher J Mungall
    • , Corey L Reynolds
    • , Juan Gallegos
    • , Valerie Gailus-Durner
    • , Tania Sorg
    • , Guillaume Pavlovic
    • , Lynette R Bower
    • , Mark Moore
    • , Iva Morse
    • , Xiang Gao
    • , Glauco P Tocchini-Valentini
    • , Yuichi Obata
    • , Soo Young Cho
    • , Je Kyung Seong
    • , John Seavitt
    • , Arthur L Beaudet
    • , Mary E Dickinson
    • , Yann Herault
    • , Wolfgang Wurst
    • , Martin Hrabe de Angelis
    • , K C Kent Lloyd
    • , Ann M Flenniken
    • , Lauryl M J Nutter
    • , Susan Newbigging
    • , Colin McKerlie
    • , Monica J Justice
    • , Stephen A Murray
    • , Karen L Svenson
    • , Robert E Braun
    • , Jacqueline K White
    • , Allan Bradley
    • , Paul Flicek
    • , Sara Wells
    • , William C Skarnes
    • , David J Adams
    • , Helen Parkinson
    • , Ann-Marie Mallon
    • , Steve D M Brown
    •  & Damian Smedley
  • Article |

    Schahram Akbarian and colleagues report that mutation of the gene encoding the SETDB1 (KMT1E) histone methyltransferase in mouse neurons leads to dissolution of chromosome conformations and a topologically associated domain at the clustered protocadherin locus. They show that SETDB1 prevents excess CTCF binding and is important for maintaining developmentally important higher-order chromatin organization.

    • Yan Jiang
    • , Yong-Hwee Eddie Loh
    • , Prashanth Rajarajan
    • , Teruyoshi Hirayama
    • , Will Liao
    • , Bibi S Kassim
    • , Behnam Javidfar
    • , Brigham J Hartley
    • , Lisa Kleofas
    • , Royce B Park
    • , Benoit Labonte
    • , Seok-Man Ho
    • , Sandhya Chandrasekaran
    • , Catherine Do
    • , Brianna R Ramirez
    • , Cyril J Peter
    • , Julia T C W
    • , Brian M Safaie
    • , Hirofumi Morishita
    • , Panos Roussos
    • , Eric J Nestler
    • , Anne Schaefer
    • , Benjamin Tycko
    • , Kristen J Brennand
    • , Takeshi Yagi
    • , Li Shen
    •  & Schahram Akbarian

Letters

  • Letter |

    Kari Stefansson and colleagues identify a nonsense mutation in RBM12 segregating with psychosis in an extended Icelandic pedigree and an independent frameshift mutation in RBM12 segregating with psychosis in a Finnish family. They further show that carriers of the Icelandic mutation who are unaffected by psychosis exhibit a psychiatric disorder and cognitive test battery profile resembling that of patients with schizophrenia.

    • Stacy Steinberg
    • , Steinunn Gudmundsdottir
    • , Gardar Sveinbjornsson
    • , Jaana Suvisaari
    • , Tiina Paunio
    • , Minna Torniainen-Holm
    • , Michael L Frigge
    • , Gudrun A Jonsdottir
    • , Johanna Huttenlocher
    • , Sunna Arnarsdottir
    • , Oddur Ingimarsson
    • , Magnus Haraldsson
    • , Thorarinn Tyrfingsson
    • , Thorgeir E Thorgeirsson
    • , Augustine Kong
    • , Gudmundur L Norddahl
    • , Daniel F Gudbjartsson
    • , Engilbert Sigurdsson
    • , Hreinn Stefansson
    •  & Kari Stefansson
  • Letter |

    Ralph McGinnis, Valgerdur Steinthorsdottir, Linda Morgan and colleagues perform a genome-wide association study in the offspring of preeclampsia pregnancies and identify variants in the fetal genome near FLT1 that are associated with risk of preeclampsia. FLT1 is known to encode an isoform of placental origin implicated in the pathology of preeclampsia, providing biological support for the association of this locus with preeclampsia risk.

    • Ralph McGinnis
    • , Valgerdur Steinthorsdottir
    • , Nicholas O Williams
    • , Gudmar Thorleifsson
    • , Scott Shooter
    • , Sigrun Hjartardottir
    • , Suzannah Bumpstead
    • , Lilja Stefansdottir
    • , Lucy Hildyard
    • , Jon K Sigurdsson
    • , John P Kemp
    • , Gabriela B Silva
    • , Liv Cecilie V Thomsen
    • , Tiina Jääskeläinen
    • , Eero Kajantie
    • , Sally Chappell
    • , Noor Kalsheker
    • , Ashley Moffett
    • , Susan Hiby
    • , Wai Kwong Lee
    • , Sandosh Padmanabhan
    • , Nigel A B Simpson
    • , Vivien A Dolby
    • , Eleonora Staines-Urias
    • , Stephanie M Engel
    • , Anita Haugan
    • , Lill Trogstad
    • , Gulnara Svyatova
    • , Nodira Zakhidova
    • , Dilbar Najmutdinova
    • , The FINNPEC Consortium
    • , Hannele Laivuori
    • , Seppo Heinonen
    • , Eero Kajantie
    • , Juha Kere
    • , Katja Kivinen
    • , Anneli Pouta
    • , The GOPEC Consortium
    • , Linda Morgan
    • , Fiona Broughton Pipkin
    • , Noor Kalsheker
    • , James J Walker
    • , Sheila Macphail
    • , Mark Kilby
    • , Marwan Habiba
    • , Catherine Williamson
    • , Kevin O'Shaughnessy
    • , Shaughn O'Brien
    • , Alan Cameron
    • , Lucilla Poston
    • , Zofia Miedzybrodzka
    • , Christopher W G Redman
    • , Martin Farrall
    • , Mark Caulfield
    • , Anna F Dominiczak
    • , Anna F Dominiczak
    • , Håkon K Gjessing
    • , Juan P Casas
    • , Frank Dudbridge
    • , James J Walker
    • , Fiona Broughton Pipkin
    • , Unnur Thorsteinsdottir
    • , Reynir T Geirsson
    • , Debbie A Lawlor
    • , Ann-Charlotte Iversen
    • , Per Magnus
    • , Hannele Laivuori
    • , Kari Stefansson
    •  & Linda Morgan
  • Letter |

    Rogier Versteeg, Johan van Nes and colleagues report that neuroblastomas comprise two cell types, mesenchymal and adrenergic, that have different responses to chemotherapeutic agents in vitro. Using ChIP–seq and expression profiling of pairs of phenotypically divergent isogenic cell lines, they identify candidate transcription factors for regulation of the two cell states.

    • Tim van Groningen
    • , Jan Koster
    • , Linda J Valentijn
    • , Danny A Zwijnenburg
    • , Nurdan Akogul
    • , Nancy E Hasselt
    • , Marloes Broekmans
    • , Franciska Haneveld
    • , Natalia E Nowakowska
    • , Johannes Bras
    • , Carel J M van Noesel
    • , Aldo Jongejan
    • , Antoine H van Kampen
    • , Linda Koster
    • , Frank Baas
    • , Lianne van Dijk-Kerkhoven
    • , Margriet Huizer-Smit
    • , Maria C Lecca
    • , Alvin Chan
    • , Arjan Lakeman
    • , Piet Molenaar
    • , Richard Volckmann
    • , Ellen M Westerhout
    • , Mohamed Hamdi
    • , Peter G van Sluis
    • , Marli E Ebus
    • , Jan J Molenaar
    • , Godelieve A Tytgat
    • , Bart A Westerman
    • , Johan van Nes
    •  & Rogier Versteeg
  • Letter |

    Ian Alexander and colleagues characterize a liver-specific enhancer–promoter element that is found in the genome of wild-type adeno-associated virus type 2 (AAV2), from which gene transfer vectors have been derived. They suggest that these sequences could provide a possible link between AAV integration events in the liver and gene dysregulation and pathogenesis.

    • Grant J Logan
    • , Allison P Dane
    • , Claus V Hallwirth
    • , Christine M Smyth
    • , Emilie E Wilkie
    • , Anais K Amaya
    • , Erhua Zhu
    • , Neeta Khandekar
    • , Samantha L Ginn
    • , Sophia H Y Liao
    • , Sharon C Cunningham
    • , Natsuki Sasaki
    • , Martí Cabanes-Creus
    • , Patrick P L Tam
    • , David W Russell
    • , Leszek Lisowski
    •  & Ian E Alexander
  • Letter |

    Junko Takita, Seishi Ogawa and colleagues profile 121 cases of pediatric T cell acute lymphoblasic leukemia (T-ALL) and identify recurrent SPI1 (PU.1) gene fusions. They find that these SPI1 fusions correlated with poor survival, retained transcriptional activity and, in a mouse stem cell model, enhanced cell proliferation.

    • Masafumi Seki
    • , Shunsuke Kimura
    • , Tomoya Isobe
    • , Kenichi Yoshida
    • , Hiroo Ueno
    • , Yaeko Nakajima-Takagi
    • , Changshan Wang
    • , Lin Lin
    • , Ayana Kon
    • , Hiromichi Suzuki
    • , Yusuke Shiozawa
    • , Keisuke Kataoka
    • , Yoichi Fujii
    • , Yuichi Shiraishi
    • , Kenichi Chiba
    • , Hiroko Tanaka
    • , Teppei Shimamura
    • , Kyoko Masuda
    • , Hiroshi Kawamoto
    • , Kentaro Ohki
    • , Motohiro Kato
    • , Yuki Arakawa
    • , Katsuyoshi Koh
    • , Ryoji Hanada
    • , Hiroshi Moritake
    • , Masaharu Akiyama
    • , Ryoji Kobayashi
    • , Takao Deguchi
    • , Yoshiko Hashii
    • , Toshihiko Imamura
    • , Atsushi Sato
    • , Nobutaka Kiyokawa
    • , Akira Oka
    • , Yasuhide Hayashi
    • , Masatoshi Takagi
    • , Atsushi Manabe
    • , Akira Ohara
    • , Keizo Horibe
    • , Masashi Sanada
    • , Atsushi Iwama
    • , Hiroyuki Mano
    • , Satoru Miyano
    • , Seishi Ogawa
    •  & Junko Takita
  • Letter |

    Jeff Hasty and colleagues use an endonuclease from S. cerevisiae along with quorum sensing from A. fischeri to produce sustained cycling of DNA plasmid concentration across a colony of E. coli cells. This copy number modulation system enables dynamic regulation of gene circuit elements without the need for specially engineered promoters.

    • Leo Baumgart
    • , William Mather
    •  & Jeff Hasty

Corrigenda

  • Corrigendum |

    • Unnur Styrkarsdottir
    • , Hannes Helgason
    • , Asgeir Sigurdsson
    • , Gudmundur L Norddahl
    • , Arna B Agustsdottir
    • , Louise N Reynard
    • , Amanda Villalvilla
    • , Gisli H Halldorsson
    • , Aslaug Jonasdottir
    • , Audur Magnusdottir
    • , Asmundur Oddson
    • , Gerald Sulem
    • , Florian Zink
    • , Gardar Sveinbjornsson
    • , Agnar Helgason
    • , Hrefna S Johannsdottir
    • , Anna Helgadottir
    • , Hreinn Stefansson
    • , Solveig Gretarsdottir
    • , Thorunn Rafnar
    • , Ina S Almdahl
    • , Anne Brækhus
    • , Tormod Fladby
    • , Geir Selbæk
    • , Farhad Hosseinpanah
    • , Fereidoun Azizi
    • , Jung Min Koh
    • , Nelson L S Tang
    • , Maryams Danesphour
    • , Jose I Mayordomo
    • , Corrine Welt
    • , Peter S Braund
    • , Nilesh J Samani
    • , Lambertus A Kiemeney
    • , L Stefan Lohmander
    • , Claus Christiansen
    • , Ole A Andreassen
    • , arcOGEN consortium
    • , Olafur Magnusson
    • , Gisli Masson
    • , Augustine Kong
    • , Ingileif Jonsdottir
    • , Daniel Gudbjartsson
    • , Patrick Sulem
    • , Helgi Jonsson
    • , John Loughlin
    • , Thorvaldur Ingvarsson
    • , Unnur Thorsteinsdottir
    •  & Kari Stefansson

Erratum

  • Erratum |

    • Ingrid E Christophersen
    • , Michiel Rienstra
    • , Carolina Roselli
    • , Xiaoyan Yin
    • , Bastiaan Geelhoed
    • , John Barnard
    • , Honghuang Lin
    • , Dan E Arking
    • , Albert V Smith
    • , Christine M Albert
    • , Mark Chaffin
    • , Nathan R Tucker
    • , Molong Li
    • , Derek Klarin
    • , Nathan A Bihlmeyer
    • , Siew-Kee Low
    • , Peter E Weeke
    • , Martina Müller-Nurasyid
    • , J Gustav Smith
    • , Jennifer A Brody
    • , Maartje N Niemeijer
    • , Marcus Dörr
    • , Stella Trompet
    • , Jennifer Huffman
    • , Stefan Gustafsson
    • , Claudia Schurmann
    • , Marcus E Kleber
    • , Leo-Pekka Lyytikäinen
    • , Ilkka Seppälä
    • , Rainer Malik
    • , Andrea R V R Horimoto
    • , Marco Perez
    • , Juha Sinisalo
    • , Stefanie Aeschbacher
    • , Sébastien Thériault
    • , Jie Yao
    • , Farid Radmanesh
    • , Stefan Weiss
    • , Alexander Teumer
    • , Seung Hoan Choi
    • , Lu-Chen Weng
    • , Sebastian Clauss
    • , Rajat Deo
    • , Daniel J Rader
    • , Svati H Shah
    • , Albert Sun
    • , Jemma C Hopewell
    • , Stephanie Debette
    • , Ganesh Chauhan
    • , Qiong Yang
    • , Bradford B Worrall
    • , Guillaume Paré
    • , Yoichiro Kamatani
    • , Yanick P Hagemeijer
    • , Niek Verweij
    • , Joylene E Siland
    • , Michiaki Kubo
    • , Jonathan D Smith
    • , David R Van Wagoner
    • , Joshua C Bis
    • , Siegfried Perz
    • , Bruce M Psaty
    • , Paul M Ridker
    • , Jared W Magnani
    • , Tamara B Harris
    • , Lenore J Launer
    • , M Benjamin Shoemaker
    • , Sandosh Padmanabhan
    • , Jeffrey Haessler
    • , Traci M Bartz
    • , Melanie Waldenberger
    • , Peter Lichtner
    • , Marina Arendt
    • , Jose E Krieger
    • , Mika Kähönen
    • , Lorenz Risch
    • , Alfredo J Mansur
    • , Annette Peters
    • , Blair H Smith
    • , Lars Lind
    • , Stuart A Scott
    • , Yingchang Lu
    • , Erwin B Bottinger
    • , Jussi Hernesniemi
    • , Cecilia M Lindgren
    • , Jorge A Wong
    • , Jie Huang
    • , Markku Eskola
    • , Andrew P Morris
    • , Ian Ford
    • , Alex P Reiner
    • , Graciela Delgado
    • , Lin Y Chen
    • , Yii-Der Ida Chen
    • , Roopinder K Sandhu
    • , Man Li
    • , Eric Boerwinkle
    • , Lewin Eisele
    • , Lars Lannfelt
    • , Natalia Rost
    • , Christopher D Anderson
    • , Kent D Taylor
    • , Archie Campbell
    • , Patrik K Magnusson
    • , David Porteous
    • , Lynne J Hocking
    • , Efthymia Vlachopoulou
    • , Nancy L Pedersen
    • , Kjell Nikus
    • , Marju Orho-Melander
    • , Anders Hamsten
    • , Jan Heeringa
    • , Joshua C Denny
    • , Jennifer Kriebel
    • , Dawood Darbar
    • , Christopher Newton-Cheh
    • , Christian Shaffer
    • , Peter W Macfarlane
    • , Stefanie Heilmann-Heimbach
    • , Peter Almgren
    • , Paul L Huang
    • , Nona Sotoodehnia
    • , Elsayed Z Soliman
    • , Andre G Uitterlinden
    • , Albert Hofman
    • , Oscar H Franco
    • , Uwe Völker
    • , Karl-Heinz Jöckel
    • , Moritz F Sinner
    • , Henry J Lin
    • , Xiuqing Guo
    • , METASTROKE Consortium of the ISGC, Neurology Working Group of the CHARGE Consortium
    • , Martin Dichgans
    • , Erik Ingelsson
    • , Charles Kooperberg
    • , Olle Melander
    • , Ruth J F Loos
    • , Jari Laurikka
    • , David Conen
    • , Jonathan Rosand
    • , Pim van der Harst
    • , Marja-Liisa Lokki
    • , Sekar Kathiresan
    • , Alexandre Pereira
    • , J Wouter Jukema
    • , Caroline Hayward
    • , Jerome I Rotter
    • , Winfried März
    • , Terho Lehtimäki
    • , Bruno H Stricker
    • , Mina K Chung
    • , Stephan B Felix
    • , Vilmundur Gudnason
    • , Alvaro Alonso
    • , Dan M Roden
    • , Stefan Kääb
    • , Daniel I Chasman
    • , Susan R Heckbert
    • , Emelia J Benjamin
    • , Toshihiro Tanaka
    • , Kathryn L Lunetta
    • , Steven A Lubitz
    • , Patrick T Ellinor
    •  & for the AFGen Consortium