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Volume 35 Issue 2, October 2003

Cover art:Spirals Time/Time Spiralsby Charles A. JencksPhotographed by Miriam Chua

Volume 35 Issue 2

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Editorial

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Book Review

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News & Views

  • Biochemical purification has identified a new component of the Fanconi anemia complex. The protein has ubiquitin ligase activity and may be the long-sought enzyme responsible for monoubiquitination of FANCD2.

    • Markus Grompe
    News & Views

  • The visual pigment rhodopsin consists of the apoprotein opsin and the retinoid chromophore 11-cis-retinal. Visual signaling is triggered upon photoisomerization of 11-cis-retinal into all-trans-retinal. A new study shows that visual signaling by opsin in the absence of chromophore is a pathogenetic mechanism of visual cell loss.

    • Charlotte E Remé
    • Andreas Wenzel
    News & Views

  • Ischemic stroke is a late-onset, complex polygenic disease, and it has proven difficult to identify its genetic determinants. A new study from Iceland shows that the gene encoding phosphodiesterase 4D is the most likely positional and pathophysiological candidate underlying the stroke susceptibility locus on chromosome 5q12.

    • Anna F Dominiczak
    • Martin W McBride
    News & Views

  • Groups of interacting proteins define functional modules that govern a cell's activity. A new study suggests that specific interaction motifs and their constituents are highly conserved across species, identifying potential functional modules used in the evolutionary process.

    • Alessandro Vespignani
    News & Views
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Brief Communication

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Article

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Letter

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