Volume 26 Issue 2, October 2000

Volume 26 Issue 2

Cover art by Christine McCarthy

Editorial

News and Views

  • News & Views |

    Apart from resistance to infectious disease, there are few examples of adaptive molecular evolution in humans. A new study indicates that olfactory receptors are exceptions, with natural selection maintaining considerable allelic diversity in this multigene family.

    • Mark Seielstad
  • News & Views |

    The inability to construct animal models of human diseases caused by mutated mitochondrial DNA (mtDNA) has been a major obstacle to investigating pathogenetic mechanisms associated with specific mtDNA mutations. Mice carrying a large-scale deletion in mtDNA have now been produced. They display some of the key features of the human disorder, but there are surprising differences.

    • Eric A Shoubridge
  • News & Views |

    Pair-wise genome comparisons offer new sources of information about the patterns and processes that influence genomic designs. Replication-dependent rearrangements, as indicated by the symmetric gene organization pattern in the genomes of Chlamydia pneumoniae and Chlamydia trachomatis, may provide a missing link in the reconstruction of historical events from modern genomes.

    • Siv GE Andersson
  • News & Views |

    Positional cloning of common disease genes is a central but elusive goal of human geneticists. Progress is now reported by Bell and colleagues in their study of NIDDM1, a locus implicated in type 2 diabetes. The complex nature of the reported association illustrates the challenge of implicating a specific gene and mutation in the causation of polygenic disease.

    • David Altshuler
    • , Mark Daly
    •  & Leonid Kruglyak

Brief Communications

Book Review

Commentary

  • Commentary |

    “They all talked at once, their voices insistent and contradictory and impatient, making of unreality a possibility, then a probability, then an incontrovertible fact, as people will when their desires become words.” —W. Faulkner, The Sound and the Fury, 1929

    • Kenneth M. Weiss
    •  & Joseph D. Terwilliger

Progress

Articles

Letters