Volume 25 Issue 2, June 2000

Volume 25 Issue 2

Cover art by Mitsuko Hoshino

Editorial

News and Views

  • News & Views |

    Wedding genetics with genomics, two groups1,2,3 have independently identified in mammals a multigene family encoding seven-transmembrane proteins that probably represent the hitherto elusive taste receptors. Functional expression in heterologous cells confers responsiveness to bitter tastants in several cases. This discovery may lead to the design of bitter antagonists—and perhaps better butter for Betty Botter.

    • Peter Mombaerts
  • News & Views |

    The Saccharomyces cerevisiae gene SGS1 encodes a protein related to the human DNA helicases defective in Werner syndrome, Bloom syndrome and Rothmund-Thomson syndrome. Yeast cells lacking the Sgs1 helicase and a related helicase, Srs2, are inviable or grow extremely poorly. The growth defect can be rescued by crippling the homologous recombination repair pathway, indicating that the essential function of these genes is related to recombination

    • Hannah L Klein
  • News & Views |

    Thanks to their much-lauded potential in treating a variety of debilitating diseases, and their recent isolation, human embryonic stem (ES) cells1 have been the focus of a great deal of attention over the past several months. And yet we are startlingly ignorant of the biology of stem cells and their differentiation; an intimate appreciation of these is required to realize therapeutic aspirations. A timely meeting * in mid-April brought together investigators with expertise in stem cell biology and developmental biology of the pancreas as a first step to harness stem cells in the treatment of diabetes.

    • Palle Serup
  • News & Views |

    Apoptotic and necrotic cells are strong candidates as sources of the autoantigens that drive the autoantibody response in systemic lupus erythematosus (SLE). Defects in the physiological mechanisms for the clearance of dying cells may promote disease susceptibility to SLE. Ablation of the mouse gene Dnase1 results in the development of anti-chromatin autoimmunity and glomerulonephritis, indicating that the enzyme protects against autoimmunity by digesting extracellular chromatin.

    • Mark J Walport

Correspondence

Brief Communications

New Technology

Articles

  • Article |

    • Graham R. Bignell
    • , William Warren
    • , Sheila Seal
    • , Meiko Takahashi
    • , Elizabeth Rapley
    • , Rita Barfoot
    • , Helen Green
    • , Carolanne Brown
    • , Patrick J. Biggs
    • , Sunil R. Lakhani
    • , Christopher Jones
    • , Juliana Hansen
    • , Edward Blair
    • , Benedikt Hofmann
    • , Reiner Siebert
    • , Gwen Turner
    • , D. Gareth Evans
    • , Connie Schrander-Stumpel
    • , Frits A. Beemer
    • , Ans van den Ouweland
    • , Dicky Halley
    • , Bertrand Delpech
    • , Mark G. Cleveland
    • , Irene Leigh
    • , Jaakko Leisti
    • , Sonja Rasmussen
    • , Margaret R. Wallace
    • , Christiane Fenske
    • , Piu Banerjee
    • , Naoki Oiso
    • , Ranbir Chaggar
    • , Samantha Merrett
    • , Niamh Leonard
    • , Marcel Huber
    • , Daniel Hohl
    • , Pam Chapman
    • , John Burn
    • , Sally Swift
    • , Anna Smith
    • , Alan Ashworth
    •  & Michael R. Stratton

Letters

Erratum