News & Comment

  • Editorial |

    The field of cancer genomics is currently in an exciting and fast-paced era. With advances in sequencing technologies, computational approaches and tumor models, understanding of cancer processes is at an all-time high, and the application of new methods to studying cancer holds great promise for developing important breakthroughs in cancer treatment and prevention.

  • News & Views |

    The conserved ligand–receptor pair CLAVATA1–CLAVATA3, which maintains homeostasis in shoot apical meristems, responds differently to perturbation in tomato, Arabidopsis and maize. Active compensation occurs in CLE signaling peptides in tomato, but compensation is passive in Arabidopsis.

    • Elizabeth A. Kellogg
  • Comment |

    The Nordic region, comprising primarily Denmark, Estonia, Finland, Iceland, Norway and Sweden, has many of the necessary characteristics for being at the forefront of genome-based precision medicine. These include egalitarian and universal healthcare, expertly curated patient and population registries, biobanks, large population-based prospective cohorts linked to registries and biobanks, and a widely embraced sense of social responsibility that motivates public engagement in biomedical research. However, genome-based precision medicine can be achieved only through coordinated action involving all actors in the healthcare sector. Now is an opportune time to organize scientists in the Nordic region, together with other stakeholders including patient representatives, governments, pharmaceutical companies, academic institutions and funding agencies, to initiate a Nordic Precision Medicine Initiative. We present a roadmap for how this organization can be created. The Initiative should facilitate research, clinical trials and knowledge transfer to meet regional and global health challenges.

    • Pål Rasmus Njølstad
    • , Ole Andreas Andreassen
    • , Søren Brunak
    • , Anders D. Børglum
    • , Joakim Dillner
    • , Tõnu Esko
    • , Paul W. Franks
    • , Nelson Freimer
    • , Leif Groop
    • , Hakon Heimer
    • , David M. Hougaard
    • , Eivind Hovig
    • , Kristian Hveem
    • , Anu Jalanko
    • , Jaakko Kaprio
    • , Gun Peggy Knudsen
    • , Mads Melbye
    • , Andres Metspalu
    • , Preben Bo Mortensen
    • , Juni Palmgren
    • , Aarno Palotie
    • , Wenche Reed
    • , Hreinn Stefánsson
    • , Nathan O. Stitziel
    • , Patrick F. Sullivan
    • , Unnur Thorsteinsdóttir
    • , Marc Vaudel
    • , Eero Vuorio
    • , Thomas Werge
    • , Camilla Stoltenberg
    •  & Kári Stefánsson
  • News & Views |

    Resolving variant-to-function relationships is a key challenge faced by human geneticists. A new study combining statistical fine-mapping with cell-type-specific functional annotations advances the understanding of the regulatory consequences of genetic variants associated with variations in blood-cell traits.

    • Manuel Tardaguila
    •  & Nicole Soranzo
  • News & Views |

    More than one dozen hereditary ataxias are caused by repeat expansions. A newly discovered expansion may be the first known common genetic cause of late-onset ataxia.

    • Vikram Shakkottai
    •  & Henry Paulson
  • Editorial |

    Genetic resources and analyses overwhelmingly center on individuals of European ancestry. We encourage the community to embrace a global approach to genetic and genomic studies to address imbalances in the composition of cohorts and the subsequent translatability of findings.

  • News & Views |

    The origin of strawberry is truly global, involving both natural processes and human intervention. The strawberry genome sequence provides support for an influential hypothesis of genome dominance.

    • David J. Bertioli
  • Editorial |

    The development of CRISPR–Cas technology and its applications in biomedical research have generated much excitement. If fully realized, this technology has the potential to help treat or prevent severe diseases. However, these tools also carry considerable risk if improperly used. The scientific community must promote constructive dialogue among its members and within society at large to ensure that research on genome editing is conducted responsibly.

  • Editorial |

    Ensuring that agricultural production meets the goal of feeding a world experiencing continued human population growth and increasingly severe effects from climate change is an urgent challenge. Genomics has a role to play in maximizing the utility, diversity and yield of resources, as well as in contributing to sustained food security in the future.

  • News & Views |

    Contemporary genomics and informatics technologies were used to provide a meaningful and insightful overview of more than 20,000 wild and domesticated barley genotypes from one of the largest crop germplasm collections. The data provide a framework for the rational exploitation of genetic resources in crop improvement, which will be central to addressing global food security.

    • Peter Langridge
    •  & Robbie Waugh
  • Correspondence |

    • Weiyin Zhou
    • , Mitchell J. Machiela
    • , Neal D. Freedman
    • , Nathaniel Rothman
    • , Nuria Malats
    • , Casey Dagnall
    • , Neil Caporaso
    • , Lauren T. Teras
    • , Mia M. Gaudet
    • , Susan M. Gapstur
    • , Victoria L. Stevens
    • , Kevin B. Jacobs
    • , Joshua Sampson
    • , Demetrius Albanes
    • , Stephanie Weinstein
    • , Jarmo Virtamo
    • , Sonja Berndt
    • , Robert N. Hoover
    • , Amanda Black
    • , Debra Silverman
    • , Jonine Figueroa
    • , Montserrat Garcia-Closas
    • , Francisco X. Real
    • , Julie Earl
    • , Gaelle Marenne
    • , Benjamin Rodriguez-Santiago
    • , Margaret Karagas
    • , Alison Johnson
    • , Molly Schwenn
    • , Xifeng Wu
    • , Jian Gu
    • , Yuanqing Ye
    • , Amy Hutchinson
    • , Margaret Tucker
    • , Luis A. Perez-Jurado
    • , Michael Dean
    • , Meredith Yeager
    •  & Stephen J. Chanock
  • News & Views |

    The genomes for essentially all worm parasites of humans are in hand thanks to a new study. Now we have to use them.

    • Paul W. Sternberg
  • Editorial |

    Well-designed science education via social media may help to reach a larger group of audiences with the aim of reducing the boundaries between researchers and the public. This may, in turn, move basic science toward translational improvement in human health and agriculture.

  • News & Views |

    A new study identifies loss-of-function mutations in HAVCR2, which encodes TIM-3, in patients with a rare cutaneous T cell lymphoma associated with aberrant immunological activation. These mutations lead to loss of the TIM-3 immunological checkpoint, thus promoting inflammation and malignancy.

    • Karen O. Dixon
    • , Madhumita Das
    •  & Vijay K. Kuchroo
  • Correspondence |

    • Maxime Tarabichi
    • , Iñigo Martincorena
    • , Moritz Gerstung
    • , Armand M. Leroi
    • , Florian Markowetz
    • , Stefan C. Dentro
    • , Ignaty Leshchiner
    • , Moritz Gerstung
    • , Clemency Jolly
    • , Kerstin Haase
    • , Maxime Tarabichi
    • , Jeff Wintersinger
    • , Amit G. Deshwar
    • , Kaixian Yu
    • , Santiago Gonzalez
    • , Yulia Rubanova
    • , Geoff Macintyre
    • , David J. Adams
    • , Pavana Anur
    • , Rameen Beroukhim
    • , Paul C. Boutros
    • , David D. Bowtell
    • , Peter J. Campbell
    • , Shaolong Cao
    • , Elizabeth L. Christie
    • , Marek Cmero
    • , Yupeng Cun
    • , Kevin J. Dawson
    • , Jonas Demeulemeester
    • , Nilgun Donmez
    • , Ruben M. Drews
    • , Roland Eils
    • , Yu Fan
    • , Matthew Fittall
    • , Dale W. Garsed
    • , Gad Getz
    • , Gavin Ha
    • , Marcin Imielinski
    • , Lara Jerman
    • , Yuan Ji
    • , Kortine Kleinheinz
    • , Juhee Lee
    • , Henry Lee-Six
    • , Dimitri G. Livitz
    • , Salem Malikic
    • , Florian Markowetz
    • , Iñigo Martincorena
    • , Thomas J. Mitchell
    • , Ville Mustonen
    • , Layla Oesper
    • , Martin Peifer
    • , Myron Peto
    • , Benjamin J. Raphael
    • , Daniel Rosebrock
    • , S. Cenk Sahinalp
    • , Adriana Salcedo
    • , Matthias Schlesner
    • , Steven Schumacher
    • , Subhajit Sengupta
    • , Ruian Shi
    • , Seung Jun Shin
    • , Lincoln D. Stein
    • , Ignacio Vázquez-García
    • , Shankar Vembu
    • , David A. Wheeler
    • , Tsun-Po Yang
    • , Xiaotong Yao
    • , Ke Yuan
    • , Hongtu Zhu
    • , Wenyi Wang
    • , Quaid D. Morris
    • , Paul T. Spellman
    • , David C. Wedge
    • , Peter Van Loo
    • , Paul T. Spellman
    • , Quaid D. Morris
    • , Ole Christian Lingjærde
    • , David C. Wedge
    •  & Peter Van Loo
  • Correspondence |

    • Timon Heide
    • , Luis Zapata
    • , Marc J. Williams
    • , Benjamin Werner
    • , Giulio Caravagna
    • , Chris P. Barnes
    • , Trevor A. Graham
    •  & Andrea Sottoriva
  • Correspondence |

    • Lars A. Forsberg
    • , Jonatan Halvardson
    • , Edyta Rychlicka-Buniowska
    • , Marcus Danielsson
    • , Behrooz Torabi Moghadam
    • , Jonas Mattisson
    • , Chiara Rasi
    • , Hanna Davies
    • , Lars Lind
    • , Vilmantas Giedraitis
    • , Lars Lannfelt
    • , Lena Kilander
    • , Martin Ingelsson
    •  & Jan P. Dumanski
  • Editorial |

    We are inviting presubmission enquiries for Articles, Perspectives and Analyses on human, animal, plant and microbial genetics and genomics from Africa, by corresponding authors living and working in African countries, with the aim of publishing an issue of the journal devoted to African genetics.

  • News & Views |

    The availability of various public resources has hastened the discovery of type 2 diabetes–associated loci in the largest genome-wide association study of the disease reported to date. In addition, these resources have also enabled researchers to get closer to determining the culprit genetic variants and therefore closer to the target effector genes driving these associations.

    • Diana L. Cousminer
    •  & Struan F. A. Grant
  • Editorial |

    A number of journalistic reports over the last year have drawn attention to dismaying trends in maternal and fetal health in the United States, particularly among African Americans. This public health crisis highlights the need for research into the genetic basis of maternal–fetal health and consideration of the genetic risk factors and exposures of women and children in diverse populations more broadly.

  • News & Views |

    Patient-derived cancer cell lines could address two major challenges in oncology: real-time drug response prediction and the creation of massive knowledge banks. A new study showcases the power of this approach for precision oncology.

    • Ultan McDermott
  • News & Views |

    A new study uncovers novel copy number signatures in ovarian cancer genomes. This work sheds light on mutational processes driving ovarian cancer, reveals the distribution of copy number features across the patient population and identifies new genomic properties related to treatment response.

    • Sohrab P. Shah
  • Editorial |

    Precision genomic medicine is now technically feasible. Just as global positioning systems revolutionized the logistics of travel, so genome-wide polygenic risk scores (GPSs) now have the potential to inform our trajectories of health and to serve in the prevention and mitigation of many common and complex diseases. We welcome research into the implementation of—and equity of access to—genetic predictors and their integration into clinical and evidence-based medical practice.

  • News & Views |

    Two new studies show that a plant-specific complex composed of EBS, or its homolog SHL, and EMF1 acts as a chromatin reader within the Polycomb pathway and effects gene repression. Two domains of EBS and SHL bind distinct chromatin modifications that are associated with active and repressed chromatin.

    • Kristin Krause
    •  & Franziska Turck
  • News & Views |

    Individual genome-wide polygenic risk scores (GPSs) for assessing disease susceptibility have been shown to yield both reliable and clinically meaningful results. However, certain impediments and outdated ways of thinking about health maintenance must be overcome before GPSs are adopted in routine care streams.

    • Andrew J. Schork
    • , M. Anthony Schork
    •  & Nicholas J. Schork