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Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor

Nature Genetics volume 49, pages 1141–1147 (2017)Cite this article

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Abstract

The international Testicular Cancer Consortium (TECAC) combined five published genome-wide association studies of testicular germ cell tumor (TGCT; 3,558 cases and 13,970 controls) to identify new susceptibility loci. We conducted a fixed-effects meta-analysis, including, to our knowledge, the first analysis of the X chromosome. Eight new loci mapping to 2q14.2, 3q26.2, 4q35.2, 7q36.3, 10q26.13, 15q21.3, 15q22.31, and Xq28 achieved genome-wide significance (P < 5 × 10−8). Most loci harbor biologically plausible candidate genes. We refined previously reported associations at 9p24.3 and 19p12 by identifying one and three additional independent SNPs, respectively. In aggregate, the 39 independent markers identified to date explain 37% of father-to-son familial risk, 8% of which can be attributed to the 12 new signals reported here. Our findings substantially increase the number of known TGCT susceptibility alleles, move the field closer to a comprehensive understanding of the underlying genetic architecture of TGCT, and provide further clues to the etiology of TGCT.

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Figure 1: All identified SNP markers associated with TGCT susceptibility to date.
Figure 2: Genetic association between SNP markers and TGCT risk for regions with multiple independent signals.

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References

  1. Trabert, B., Chen, J., Devesa, S.S., Bray, F. & McGlynn, K.A. International patterns and trends in testicular cancer incidence, overall and by histologic subtype, 1973–2007. Andrology 3, 4–12 (2015).

    Article  CAS  PubMed  Google Scholar 

  2. Howlader, N. et al. SEER Cancer Statistics Review, 1975–2012 (National Cancer Institute, 2015).

  3. Znaor, A., Lortet-Tieulent, J., Jemal, A. & Bray, F. International variations and trends in testicular cancer incidence and mortality. Eur. Urol. 65, 1095–1106 (2014).

    Article  PubMed  Google Scholar 

  4. Bromen, K. et al. Testicular, other genital, and breast cancers in first-degree relatives of testicular cancer patients and controls. Cancer Epidemiol. Biomarkers Prev. 13, 1316–1324 (2004).

    PubMed  Google Scholar 

  5. Chia, V.M. et al. Risk of cancer in first- and second-degree relatives of testicular germ cell tumor cases and controls. Int. J. Cancer 124, 952–957 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Heimdal, K. et al. Risk of cancer in relatives of testicular cancer patients. Br. J. Cancer 73, 970–973 (1996).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Sonneveld, D.J. et al. Familial testicular cancer in a single-centre population. Eur. J. Cancer 35, 1368–1373 (1999).

    Article  CAS  PubMed  Google Scholar 

  8. McGlynn, K.A. & Trabert, B. Adolescent and adult risk factors for testicular cancer. Nat. Rev. Urol. 9, 339–349 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Litchfield, K. et al. Quantifying the heritability of testicular germ cell tumour using both population-based and genomic approaches. Sci. Rep. 5, 13889 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Mucci, L.A. et al. Familial risk and heritability of cancer among twins in Nordic countries. J. Am. Med. Assoc. 315, 68–76 (2016).

    Article  CAS  Google Scholar 

  11. Crockford, G.P. et al. Genome-wide linkage screen for testicular germ cell tumour susceptibility loci. Hum. Mol. Genet. 15, 443–451 (2006).

    Article  CAS  PubMed  Google Scholar 

  12. Chung, C.C. et al. Meta-analysis identifies four new loci associated with testicular germ cell tumor. Nat. Genet. 45, 680–685 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Kanetsky, P.A. et al. Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer. Nat. Genet. 41, 811–815 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Kanetsky, P.A. et al. A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility. Hum. Mol. Genet. 20, 3109–3117 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Schumacher, F.R. et al. Testicular germ cell tumor susceptibility associated with the UCK2 locus on chromosome 1q23. Hum. Mol. Genet. 22, 2748–2753 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Rapley, E.A. et al. A genome-wide association study of testicular germ cell tumor. Nat. Genet. 41, 807–810 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Turnbull, C. et al. Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer. Nat. Genet. 42, 604–607 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Kristiansen, W. et al. Two new loci and gene sets related to sex determination and cancer progression are associated with susceptibility to testicular germ cell tumor. Hum. Mol. Genet. 24, 4138–4146 (2015).

    Article  CAS  PubMed  Google Scholar 

  19. Litchfield, K. et al. Identification of four new susceptibility loci for testicular germ cell tumour. Nat. Commun. 6, 8690 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Ruark, E. et al. Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14. Nat. Genet. 45, 686–689 (2013).

    Article  CAS  PubMed  Google Scholar 

  21. Litchfield, K. et al. Multi-stage genome-wide association study identifies new susceptibility locus for testicular germ cell tumour on chromosome 3q25. Hum. Mol. Genet. 24, 1169–1176 (2015).

    Article  CAS  PubMed  Google Scholar 

  22. Nathanson, K.L. et al. The Y deletion gr/gr and susceptibility to testicular germ cell tumor. Am. J. Hum. Genet. 77, 1034–1043 (2005).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Dalgaard, M.D. et al. A genome-wide association study of men with symptoms of testicular dysgenesis syndrome and its network biology interpretation. J. Med. Genet. 49, 58–65 (2012).

    Article  PubMed  Google Scholar 

  24. Wakefield, J. A Bayesian measure of the probability of false discovery in genetic epidemiology studies. Am. J. Hum. Genet. 81, 208–227 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Wong, Y.H. et al. Protogenin defines a transition stage during embryonic neurogenesis and prevents precocious neuronal differentiation. J. Neurosci. 30, 4428–4439 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Unsal-Kaçmaz, K. et al. The human Tim/Tipin complex coordinates an jntra-S checkpoint response to UV that slows replication fork displacement. Mol. Cell. Biol. 27, 3131–3142 (2007).

    Article  PubMed  PubMed Central  Google Scholar 

  27. Williams, B.C. et al. Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions. Mol. Biol. Cell 14, 1379–1391 (2003).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Almstrup, K. et al. Embryonic stem cell–like features of testicular carcinoma in situ revealed by genome-wide gene expression profiling. Cancer Res. 64, 4736–4743 (2004).

    Article  CAS  PubMed  Google Scholar 

  29. Sonne, S.B. et al. Analysis of gene expression profiles of microdissected cell populations indicates that testicular carcinoma in situ is an arrested gonocyte. Cancer Res. 69, 5241–5250 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Tang, W.W. et al. A unique gene regulatory network resets the human germline epigenome for development. Cell 161, 1453–1467 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Kristensen, D.M. et al. Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms. Hum. Reprod. 23, 775–782 (2008).

    Article  CAS  PubMed  Google Scholar 

  32. Scotland, K.B., Chen, S., Sylvester, R. & Gudas, L.J. Analysis of Rex1 (zfp42) function in embryonic stem cell differentiation. Dev. Dyn. 238, 1863–1877 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Yokoi, F., Hiraishi, H. & Izuhara, K. Molecular cloning of a cDNA for the human phospholysine phosphohistidine inorganic pyrophosphate phosphatase. J. Biochem. 133, 607–614 (2003).

    Article  CAS  PubMed  Google Scholar 

  34. Kim, J.H. et al. The condensin component NCAPG2 regulates microtubule–kinetochore attachment through recruitment of Polo-like kinase 1 to kinetochores. Nat. Commun. 5, 4588 (2014).

    Article  CAS  PubMed  Google Scholar 

  35. Schwaab, J. et al. Expression of Transketolase like gene 1 (TKTL1) predicts disease-free survival in patients with locally advanced rectal cancer receiving neoadjuvant chemoradiotherapy. BMC Cancer 11, 363 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Ahopelto, K., Böckelman, C., Hagström, J., Koskensalo, S. & Haglund, C. Transketolase-like protein 1 expression predicts poor prognosis in colorectal cancer. Cancer Biol. Ther. 17, 163–168 (2016).

    Article  CAS  PubMed  Google Scholar 

  37. Jayachandran, A. et al. Transketolase-like 1 ectopic expression is associated with DNA hypomethylation and induces the Warburg effect in melanoma cells. BMC Cancer 16, 134 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  38. Kayser, G. et al. Poor outcome in primary non–small cell lung cancers is predicted by transketolase TKTL1 expression. Pathology 43, 719–724 (2011).

    Article  PubMed  Google Scholar 

  39. Eichler, E.E. et al. Complex β-satellite repeat structures and the expansion of the zinc finger gene cluster in 19p12. Genome Res. 8, 791–808 (1998).

    Article  CAS  PubMed  Google Scholar 

  40. Mangino, M. et al. Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. Hum. Mol. Genet. 21, 5385–5394 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Auton, A. et al. A global reference for human genetic variation. Nature 526, 68–74 (2015).

    Article  PubMed  Google Scholar 

  42. Jiao, S. et al. Estimating the heritability of colorectal cancer. Hum. Mol. Genet. 23, 3898–3905 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Mancuso, N. et al. The contribution of rare variation to prostate cancer heritability. Nat. Genet. 48, 30–35 (2016).

    Article  CAS  PubMed  Google Scholar 

  44. Michailidou, K. et al. Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer. Nat. Genet. 47, 373–380 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Park, J.H. et al. Estimation of effect size distribution from genome-wide association studies and implications for future discoveries. Nat. Genet. 42, 570–575 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Hemminki, K. & Li, X. Familial risk in testicular cancer as a clue to a heritable and environmental aetiology. Br. J. Cancer 90, 1765–1770 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Purcell, S. et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559–575 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Delaneau, O., Zagury, J.F. & Marchini, J. Improved whole-chromosome phasing for disease and population genetic studies. Nat. Methods 10, 5–6 (2013).

    Article  CAS  PubMed  Google Scholar 

  49. Howie, B.N., Donnelly, P. & Marchini, J. A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet. 5, e1000529 (2009).

    Article  PubMed  PubMed Central  Google Scholar 

  50. Li, B. & Dewey, C.N. RSEM: accurate transcript quantification from RNA–Seq data with or without a reference genome. BMC Bioinformatics 12, 323 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services nor does the mention of trade names, commercial products, or organizations indicate endorsement by the US government. We thank B. Weathers for her coordination of TECAC, J. Pluta for biostatistical assistance, and K. D'Andrea for expert assistance with SNP genotyping. We thank D.R. Stewart and J.T. Loud for critical support of the NCI Clinical Genetics Branch Familial Testicular Cancer Project (NCI 02-C-0178; NCT-00039598). We also thank all previous contributors to the GWAS analyzed in this study, including N. Weinhold, D. Edsgärd, H. Leffers, and A. Juul, N.E. Skakkebæk, and S. Brunak from the Danish study.

The Testicular Cancer Consortium is supported by National Institutes of Health grant U01CA164947 to K.L.N., P.A.K., and S.M.S. A portion of this work was supported by the Intramural Research Program of the National Cancer Institute and by support services contract HHSN26120130003C with IMS, Inc. The Penn GWAS (Penn) was supported by the Abramson Cancer Center at the University of Pennsylvania and National Institute of Health grant CA114478 to K.L.N. and P.A.K. The UK testicular cancer study was supported by the Institute of Cancer Research, Cancer Research UK, and made use of control data generated by the Wellcome Trust Case Control Consortium 2 (WTCCC2). C.T. is supported by the Movember Foundation. K.L. is supported by a PhD fellowship from Cancer Research UK. L.C.P. is supported by the National Institutes of Health (T32-GM008638). The contribution from the University of Leeds was funded by Cancer Research UK (C588/A19167). The Norwegian/Swedish study was supported by the Norwegian Cancer Society (grants 418975–71081–PR-2006-0387 and PK01-2007-0375); the Nordic Cancer Union (grant S-12/07), and the Swedish Cancer Society (grants 2008/708, 2010/808, 2011/484, and CAN2012/823). The Danish GWAS was supported by the Villum Kann Rasmussen Foundation, a NABIIT grant from the Danish Strategic Research Council, the Novo Nordisk Foundation, the Danish Cancer Society, and the Danish and Swedish Childhood Cancer Foundation.

Author information

Author notes

  1. Zhaoming Wang & Lorenzo Richiardi

    Present address: Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA

  2. Peter A Kanetsky, Katherine L Nathanson and Rolf Skotheim: These authors jointly directed this work.

Authors and Affiliations

  1. Division of Cancer Epidemiology and Genetics, US Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

    Zhaoming Wang, Katherine A McGlynn, Charles C Chung, Mark H Greene, Stephen J Chanock, Katherine A McGlynn, Mark H Greene & Stephen J Chanock

  2. Department of Growth and Reproduction, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark

    Ewa Rajpert-De Meyts, Marlene D Dalgaard & Ewa Rajpert-De Meyts

  3. Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK

    D Timothy Bishop & D Timothy Bishop

  4. Department of Bio and Health Informatics, Technical University of Denmark, Kongens Lyngby, Denmark

    Marlene D Dalgaard, Ramneek Gupta, Kasper Nielsen & Ramneek Gupta

  5. Cancer Registry of Norway, Oslo, Norway

    Tom Grotmol & Tom Grotmol

  6. Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, Oslo, Norway

    Trine B Haugen & Trine B Haugen

  7. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

    Robert Karlsson, Fredrik Wiklund & Fredrik Wiklund

  8. Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK

    Kevin Litchfield, Clare Turnbull & Clare Turnbull

  9. Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Nandita Mitra

  10. Department of Medicine, Division of Translational Medicine and Human Genetics, Perelman School of Medicine at the University of Pennsylvania, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Louise C Pyle, Katherine L Nathanson & Katherine L Nathanson

  11. Division of Human Genetics and Metabolism, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

    Louise C Pyle

  12. Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

    Stephen M Schwartz & Stephen M Schwartz

  13. Institute for Systems Biology, Seattle, Washington, USA

    Vésteinn Thorsson

  14. Department of Biostatistics, Harvard School of Public Health, Harvard University, Boston, Massachusetts, USA

    Saran Vardhanabhuti

  15. Genomics England, London, UK

    Clare Turnbull & Clare Turnbull

  16. Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA

    Peter A Kanetsky & Peter A Kanetsky

  17. Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Katherine L Nathanson & Katherine L Nathanson

  18. Department of Medicine, Unit of Andrology and Reproductive Medicine, University of Padova, Padova, Italy

    Alberto Ferlin

  19. Medical Oncology, University Medical Center Groningen, Groningen, The Netherlands

    Jourik A Gietema

  20. Department of Clinical Preventive Medicine, Keck School of Medicine at the University of Southern California, University of Southern California, Los Angeles, California, USA

    Victoria Cortessis

  21. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA

    Russ Hauser

  22. Department of Epidemiology, Division of OVP, Cancer Prevention and Population Sciences, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Michelle Hildebrandt

  23. Radboud University Medical Centre, Radhoud Institute for Health Sciences, Nijmegen, Nijmegen, The Netherlands

    Lambertus A Kiemeney

  24. Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

    Christian Kubisch & Davor Lessel

  25. deCODE Genetics, Reykjavik, Iceland

    Thorunn Rafnar

  26. Department of Biostatistics and Epidemiology, University of Turin, Turin, Italy

    Nandita Mitra

  27. Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway

    Rolf Skotheim

  28. Department of Epidemiology, Brown University, Providence, Rhode Island, USA

    Tongzhang Zheng

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  1. Zhaoming Wang
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Consortia

the Testicular Cancer Consortium

  • Katherine A McGlynn
  • , Ewa Rajpert-De Meyts
  • , D Timothy Bishop
  • , Mark H Greene
  • , Ramneek Gupta
  • , Tom Grotmol
  • , Trine B Haugen
  • , Stephen M Schwartz
  • , Fredrik Wiklund
  • , Clare Turnbull
  • , Stephen J Chanock
  • , Peter A Kanetsky
  • , Katherine L Nathanson
  • , Alberto Ferlin
  • , Jourik A Gietema
  • , Victoria Cortessis
  • , Russ Hauser
  • , Michelle Hildebrandt
  • , Lambertus A Kiemeney
  • , Christian Kubisch
  • , Davor Lessel
  • , Thorunn Rafnar
  • , Lorenzo Richiardi
  • , Rolf Skotheim
  •  & Tongzhang Zheng

Contributions

K.L.N. and P.A.K. supervised the overall study. K.A.M., E.R.-D.M., D.T.B., M.D.D., M.H.G., R.G., T.G., T.B.H., K.L., K.N., S.M.S., F.W., C.T., P.A.K., and K.L.N. contributed to recruitment and to study, data management. Z.W., K.A.M., E.R.-D.M., D.T.B., M.D.D., M.H.G., R.G., T.G., T.B.H., R.K., K.L., N.M., K.N., S.V., F.W., C.T., S.J.C., P.A.K., and K.L.N. contributed to genotyping or association analysis of individual studies. Z.W., C.C.C., L.C.P., V.T., S.J.C., P.A.K., and K.L.N. carried out the meta-analysis and the additional bioinformatics analyses, including using GTEx and TCGA TGCT data. Z.W., P.A.K., and K.L.N. drafted the initial manuscript, and all authors reviewed and contributed to the manuscript.

Corresponding author

Correspondence to Katherine L Nathanson.

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The authors declare no competing financial interests.

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Wang, Z., McGlynn, K., Rajpert-De Meyts, E. et al. Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor. Nat Genet 49, 1141–1147 (2017). https://doi.org/10.1038/ng.3879

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