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Turning of COGS moves forward findings for hormonally mediated cancers

Abstract

The large-scale Collaborative Oncological Gene-environment Study (COGS) presents new findings that further characterize the genetic bases of breast, ovarian and prostate cancers. We summarize and provide insights into this collection of papers from COGS and discuss the implications of the results and future directions for such efforts.

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Figure 1
Figure 2: Pleiotropy among different cancers detected by COGS and previous association studies.

References

  1. Michailidou, K.M. et al. Nat. Genet. published online; doi:10.1038/ng.2563 (27 March 2013).

    Article  CAS  PubMed  Google Scholar 

  2. Garcia-Closas, M. et al. Nat. Genet. published online; doi:10.1038/ng.2561 (27 March 2013).

    Article  CAS  PubMed  Google Scholar 

  3. Pharoah, P.D.P. et al. Nat. Genet. published online; doi:10.1038/ng.2564 (27 March 2013).

    Article  CAS  PubMed  Google Scholar 

  4. Eeles, R.A. et al. Nat. Genet. published online; doi:10.1038/ng.2560 (27 March 2013).

    Article  CAS  PubMed  Google Scholar 

  5. Bojesen, S.E. et al. Nat. Genet. published online; doi:10.1038/ng.2566 (27 March 2013).

    Article  CAS  PubMed  Google Scholar 

  6. Couch, F.J. et al. PLoS Genet. 9, e1003212 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Gaudet, M.M. et al. PLoS Genet. 9, e1003173 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Kote-Jarai, Z. et al. Hum. Mol. Genet. published online; doi:10.1093/hmg/ddt086 (27 March 2013).

  9. French, J.D. et al. Am. J. Hum. Genet. published online; doi:10.1016/j.ajhg.2013.01.002 (27 March 2013).

  10. Zheng, W. et al. Hum. Mol. Genet. published online; doi:10.1093/hmg/ddt089 (27 March 2013).

  11. Shen, H. et al. Nat. Comm. published online; doi:10.1038/ncomms2629 (27 March 2013).

  12. Nickels, S. et al. PLoS Genet. 9, e1003284 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Permuth-Wey, J. et al. Nat. Comm. published online; doi:10.1038/ncomms2613 (27 March 2013).

  14. Barrett, J.H. et al. Nat. Genet. 43, 1108–1113 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. McKay, J.D. et al. Nat. Genet. 40, 1404–1406 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Petersen, G.M. et al. Nat. Genet. 42, 224–228 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Rafnar, T. et al. Nat. Genet. 41, 221–227 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Rajaraman, P. et al. Hum. Genet. 131, 1877–1888 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  19. Rothman, N. et al. Nat. Genet. 42, 978–984 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Turnbull, C. et al. Nat. Genet. 42, 604–607 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Freedman, M.L. et al. Nat. Genet. 43, 513–518 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Lango Allen, H. et al. Nature 467, 832–838 (2010).

    CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

This work is supported by US NIH grants R01 CA088164, U01 CA127298 and U19 CA148537.

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Correspondence to John S Witte.

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Sakoda, L., Jorgenson, E. & Witte, J. Turning of COGS moves forward findings for hormonally mediated cancers. Nat Genet 45, 345–348 (2013). https://doi.org/10.1038/ng.2587

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