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Volume 38 Issue 1, January 2006

Cover art: "Twisted wire" by Paul Kalitsis. Email: paul.kalitsis@mcri.edu.au

Volume 38 Issue 1

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Editorial

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Commentary

  • Networks of investigators have begun sharing best practices, tools and methods for analysis of associations between genetic variation and common diseases. A Network of Investigator Networks has been set up to drive the process, sponsored by the Human Genome Epidemiology Network. A workshop is planned to develop consensus guidelines for reporting results of genetic association studies. Published literature databases will be integrated, and unpublished data, including 'negative' studies, will be captured by online journals and through investigator networks. Systematic reviews will be expanded to include more meta-analyses of individual-level data and prospective meta-analyses. Field synopses will offer regularly updated overviews.

    • John P A Ioannidis
    • Marta Gwinn
    • Muin J Khoury
    Commentary
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Book Review

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News & Views

  • SNP genotyping platforms have been used to discover ∼1,000 deletion structural variants within the human genome, with median lengths ranging from 500 bp to 10.5 kb. Analyses of a subset of these provide compelling evidence of linkage disequilibrium with flanking SNPs.

    • Evan E Eichler
    News & Views

  • A new study shows that some cases of early-onset Alzheimer disease result from duplications of the APP locus, which encodes the amyloid β precursor protein. This finding fulfills a 20-year-old prediction that genetic variability in APP expression could lead to disease and provides further, perhaps definitive, evidence for the amyloid hypothesis of the disorder.

    • John Hardy
    News & Views

  • A new study shows that mutations in the gene encoding carboxyl ester lipase (CEL) cause beta cell dysfunction and early-onset diabetes. As this gene is expressed in the exocrine, and not the endocrine, pancreas, its identification challenges many of our preconceived ideas about the causes of beta cell dysfunction in diabetes.

    • Andrew T Hattersley
    News & Views

  • Complex diseases are influenced by many interacting genetic and environmental risk factors. A multiethnic case-control association study identifies a genetic variant for myocardial infarction that seems to confer higher risk in African Americans than in European Americans.

    • Hua Tang
    News & Views
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Research Highlights

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Brief Communication

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Article

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Letter

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