A new study shows that mutations in the gene encoding carboxyl ester lipase (CEL) cause beta cell dysfunction and early-onset diabetes. As this gene is expressed in the exocrine, and not the endocrine, pancreas, its identification challenges many of our preconceived ideas about the causes of beta cell dysfunction in diabetes.
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Hattersley, A. Beyond the beta cell in diabetes. Nat Genet 38, 12–13 (2006). https://doi.org/10.1038/ng0106-12
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DOI: https://doi.org/10.1038/ng0106-12
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