Brief Communications

Common genetic variation near MC4R is associated with waist circumference and insulin resistance

• John C Chambers
• Paul Elliott
• Jaspal S Kooner

Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis

• Andre Franke
• Tobias Balschun
• Stefan Schreiber

Common variants on chromosome 5p12 confer susceptibility to estrogen receptor–positive breast cancer

• Simon N Stacey
• Andrei Manolescu
• Kari Stefansson

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

• Sheila A Fisher
• Mark Tremelling
• Jack Satsangi

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

• Karin E Finberg
• Matthew M Heeney
• Mark D Fleming

TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

• Edor Kabashi
• Paul N Valdmanis
• Guy A Rouleau

Evolutionary plasticity of genetic interaction networks

• Julia Tischler
• Ben Lehner
• Andrew G Fraser

A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia

• Ian M Morison
• Elisabeth M Cramer Bordé
• Elizabeth C Ledgerwood

DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice

• Marc Vermulst
• Jonathan Wanagat
• Lawrence A Loeb

Mutations in the cyclin family member FAM58A cause an X-linked dominant disorder characterized by syndactyly, telecanthus and anogenital and renal malformations

• Sheila Unger
• Detlef Böhm
• Jürgen Kohlhase

Thromboxane synthase mutations in an increased bone density disorder (Ghosal syndrome)

• David Geneviève
• Valérie Proulle
• Valérie Cormier-Daire

Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer

• Julius Gudmundsson
• Patrick Sulem
• Kari Stefansson

Mutations in mRNA export mediator GLE1 result in a fetal motoneuron disease

• Heidi O Nousiainen
• Marjo Kestilä
• Leena Peltonen

A nonsynonymous functional variant in integrin-α_M (encoded by ITGAM) is associated with systemic lupus erythematosus

• Swapan K Nath
• Shizhong Han
• John B Harley

Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides

• Jaspal S Kooner
• John C Chambers
• John F Thompson

Ultraconservation identifies a small subset of extremely constrained developmental enhancers

• Axel Visel
• Shyam Prabhakar
• Len A Pennacchio

Impaired glycosylation and cutis laxa caused by mutations in the vesicular H⁺-ATPase subunit ATP6V0A2

• Uwe Kornak
• Ellen Reynders
• Stefan Mundlos

Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis

• Michael A van Es
• Paul WJ van Vught
• Leonard H van den Berg

Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk

• Emma Jaeger
• Emily Webb
• Ian Tomlinson

Psoriasis is associated with increased β-defensin genomic copy number

• Edward J Hollox
• Ulrike Huffmeier
• Joost Schalkwijk