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The expression of murine endogenous retrovirus-L (MERVL) is transiently upregulated at the two-cell stage in mouse embryos, coinciding with zygotic genome activation and the acquisition of totipotency; however, its role in embryogenesis remains elusive. We show that nuclear expression of MERVL is required for accurate regulation of the host transcriptome and chromatin state during preimplantation development.
A graph-based pan-genome constructed using de novo genome assemblies of ten pearl millet accessions adapted to different climates worldwide identifies structural variations and their contribution to heat tolerance in pearl millet.
MERVL transcripts, but not MERVL-encoded proteins, are essential for mouse preimplantation development. Depletion of MERVL RNA perturbs early lineage specification and leads to increased chromatin accessibility at, and transcription of, two-cell-specific genes.
Arabidopsis sperm cells exhibit widespread chromatin bivalency. Incorporation of histone variant H3.10 regulates sperm chromatin identity. In contrast, in vegetative cells, repressed genes are marked by H3K27me3, while pollination-related genes are active and marked by broad H3K4me3 domains.
Interacting proteins commonly perform similar functions. A protein interaction network analysis of genes linked to 1,002 human traits identifies molecular mechanisms that are shared across traits and so-called pleiotropic biological processes, whose disruption might affect many aspects of human biology.
Multi-omic profiling of lesions at autopsy reveals a plethora of resistance mechanisms present within individual patients with ovarian cancer. This highlights the extreme challenge faced in treating end-stage disease and underscores the need for new methods of early detection and intervention.
Multiple samples collected at autopsy from women with homologous recombination-deficient high-grade serous ovarian cancer highlight substantial inter- and intratumoral heterogeneity. A plethora of resistance mechanisms were identified within and between patients.
A meta-analysis of harmonized human brain RNA-seq datasets creates expression quantitative trait locus (eQTL) maps for multiple ancestries and brain regions, predicts cell-type-dependent eQTLs and produces gene networks. This prioritizes genes for multiple brain-related diseases, serving as a promising step toward the identification of central nervous system (CNS) drug targets.
Network expansion of trait-associated genes for 1,002 human phenotypes identifies pleiotropic gene modules and biological processes associated with multiple traits, and potential opportunities for drug repurposing and development.
High-quality genome assembly of a prominent drought-resistant maize germplasm CIMBL55 and genetic variation analyses provide a resource for genetic dissection and result in the improvement of maize drought resistance.
The identification of genes and enhancers associated with waist-to-hip ratio adjusted for body mass index (WHRadjBMI) in women highlights variants within Alu retrotransposons. The WHRadjBMI-linked gene SNX10 plays a role in human adipocyte differentiation and diet-induced adipose expansion in female mice.
