This study seeks to explain the poor overlap of genome-wide association study and cis-expression quantitative trait locus variants using a model of differential selective constraint, suggesting that these two study types have biases towards different functional classes of variants.

Mouse lineage tracing in regenerating bone marrow after myeloablation shows a dynamic dedifferentiation of mature adipocytes into bone marrow stromal cells. Lipolysis disruption obstructs adipocyte dedifferentiation and hematopoietic stem cell regeneration.

Epigenomic profiling and massively parallel reporter assays identify 892 functional differentially-active single-nucleotide variants (daSNVs) linked to ten neuropsychiatric diseases. CRISPRi and gene editing approaches show magnesium transport dysfunction as a common genetic pathomechanism.

De novo genome assemblies of 12 species from Aurantioideae and pangenome analyses provide insights into the origin and evolution of the orange subfamily and the genetic basis of flavor in citrus fruits.

A strategy for inferring phase for rare variant pairs is applied to exome sequencing data for 125,748 individuals from the Genome Aggregation Database (gnomAD). This resource will aid interpretation of rare co-occurring variants in the context of recessive disease.

Genome-wide analyses of blood cell phenotypes derived from perturbations coupled with flow cytometry-based functional readouts identify loci associated with latent cellular traits, yielding insights into biological mechanisms underlying common diseases.

A chemical-genetic approach coupled with temporally resolved chromatin profiling shows that RNAPII promoter-proximal pausing stabilizes BAF complex occupancy and promotes nucleosome eviction.

Whole-genome analysis of paired follicular lymphoma and double-hit lymphoma shows that lymphoma progression is accompanied by enhanced somatic mutations targeting super-enhancer-embedded promoters.

Implementing human genetics research: an itinerary of a researcher from low-income settings.

The preparedness of Africa for genomic medicine remains a matter of debate because this question is always evaluated from a technological standpoint. Yet the resilience of African researchers and the cultural values of equity and fairness are important assets to be considered in planning for the future of genomic medicine in Africa.