Yuxian Liu and Wei Yao

Sugarcane genome

Latest Research

  • Letter |

    Individuals with biscuspid aortic valve and ascending aortic aneurysm show enrichment of rare variants in ROBO4. Functional studies suggest that ROBO4 mutations disrupt endothelial cell performance and contribute to pathological remodeling of aortic tissues.

    • Russell A. Gould
    • , Hamza Aziz
    • , Courtney E. Woods
    • , Manuel Alejandro Seman-Senderos
    • , Elizabeth Sparks
    • , Christoph Preuss
    • , Florian Wünnemann
    • , Djahida Bedja
    • , Cassandra R. Moats
    • , Sarah A. McClymont
    • , Rebecca Rose
    • , Nara Sobreira
    • , Hua Ling
    • , Gretchen MacCarrick
    • , Ajay Anand Kumar
    • , Ilse Luyckx
    • , Elyssa Cannaerts
    • , Aline Verstraeten
    • , Hanna M. Björk
    • , Ann-Cathrin Lehsau
    • , Vinod Jaskula-Ranga
    • , Henrik Lauridsen
    • , Asad A. Shah
    • , Christopher L. Bennett
    • , Patrick T. Ellinor
    • , Honghuang Lin
    • , Eric M. Isselbacher
    • , Christian Lacks Lino Cardenas
    • , Jonathan T. Butcher
    • , G. Chad Hughes
    • , Mark E. Lindsay
    • , David Valle
    • , Hua Ling
    • , James Lupski
    • , Harry C. Dietz
    • , Andrew S. McCallion
    • , Gregor Andelfinger
    • , Bart L. Loeys
    • , Lut Van Laer
    • , Per Eriksson
    • , Salah A. Mohamed
    • , Luc Mertens
    • , Anders Franco-Cereceda
    • , Seema Mital
    • , Luc Mertens
    • , Anders Franco-Cereceda
    • , Judith M. A. Verhagen
    • , Marja Wessels
    • , Salah A. Mohamed
    • , Per Eriksson
    • , Seema Mital
    • , Lut Van Laer
    • , Bart L. Loeys
    • , Gregor Andelfinger
    • , Andrew S. McCallion
    •  & Harry C. Dietz
  • Letter | | open

    Assembly of a pan-genome from 910 humans of African descent identifies 296.5 Mb of novel DNA mapping to 125,715 distinct contigs. This African pan-genome contains ~10% more DNA than the current human reference genome.

    • Rachel M. Sherman
    • , Juliet Forman
    • , Valentin Antonescu
    • , Daniela Puiu
    • , Michelle Daya
    • , Nicholas Rafaels
    • , Meher Preethi Boorgula
    • , Sameer Chavan
    • , Candelaria Vergara
    • , Victor E. Ortega
    • , Albert M. Levin
    • , Celeste Eng
    • , Maria Yazdanbakhsh
    • , James G. Wilson
    • , Javier Marrugo
    • , Leslie A. Lange
    • , L. Keoki Williams
    • , Harold Watson
    • , Lorraine B. Ware
    • , Christopher O. Olopade
    • , Olufunmilayo Olopade
    • , Ricardo R. Oliveira
    • , Carole Ober
    • , Dan L. Nicolae
    • , Deborah A. Meyers
    • , Alvaro Mayorga
    • , Jennifer Knight-Madden
    • , Tina Hartert
    • , Nadia N. Hansel
    • , Marilyn G. Foreman
    • , Jean G. Ford
    • , Mezbah U. Faruque
    • , Georgia M. Dunston
    • , Luis Caraballo
    • , Esteban G. Burchard
    • , Eugene R. Bleecker
    • , Maria I. Araujo
    • , Edwin F. Herrera-Paz
    • , Monica Campbell
    • , Cassandra Foster
    • , Margaret A. Taub
    • , Terri H. Beaty
    • , Ingo Ruczinski
    • , Rasika A. Mathias
    • , Kathleen C. Barnes
    •  & Steven L. Salzberg
  • Letter |

    In zebrafish, cilia-driven flow of cerebrospinal fluid transports adrenergic signals that induce urotensin neuropeptides in spinal cord neurons. In turn, these neuropeptides activate their receptor on nearby muscle fibers, straightening the body axis.

    • Xiaoli Zhang
    • , Shuo Jia
    • , Zhe Chen
    • , Yan Ling Chong
    • , Haibo Xie
    • , Dong Feng
    • , Xiaotong Wu
    • , Don Zhu Song
    • , Sudipto Roy
    •  & Chengtian Zhao
  • Article |

    Integrated analysis of transcriptome, open chromatin region and chromatin conformation capture data from subjects with acute myeloid leukemia (AML) harboring defined transcription factor and signaling molecule alterations provide insights into the subtype-specific regulatory network in AML.

    • Salam A. Assi
    • , Maria Rosaria Imperato
    • , Daniel J. L. Coleman
    • , Anna Pickin
    • , Sandeep Potluri
    • , Anetta Ptasinska
    • , Paulynn Suyin Chin
    • , Helen Blair
    • , Pierre Cauchy
    • , Sally R. James
    • , Joaquin Zacarias-Cabeza
    • , L. Niall Gilding
    • , Andrew Beggs
    • , Sam Clokie
    • , Justin C. Loke
    • , Phil Jenkin
    • , Ash Uddin
    • , Ruud Delwel
    • , Stephen J. Richards
    • , Manoj Raghavan
    • , Michael J. Griffiths
    • , Olaf Heidenreich
    • , Peter N. Cockerill
    •  & Constanze Bonifer
  • Article |

    Analysis of genotyping-by-sequencing data for more than 20,000 barley accessions from a German genebank provides a framework for genomics-assisted genebank management and analysis of large germplasm collections for important crops.

    • Sara G. Milner
    • , Matthias Jost
    • , Shin Taketa
    • , Elena Rey Mazón
    • , Axel Himmelbach
    • , Markus Oppermann
    • , Stephan Weise
    • , Helmut Knüpffer
    • , Martín Basterrechea
    • , Patrick König
    • , Danuta Schüler
    • , Rajiv Sharma
    • , Raj K. Pasam
    • , Twan Rutten
    • , Ganggang Guo
    • , Dongdong Xu
    • , Jing Zhang
    • , Gerhard Herren
    • , Thomas Müller
    • , Simon G. Krattinger
    • , Beat Keller
    • , Yong Jiang
    • , Maria Y. González
    • , Yusheng Zhao
    • , Antje Habekuß
    • , Sandra Färber
    • , Frank Ordon
    • , Matthias Lange
    • , Andreas Börner
    • , Andreas Graner
    • , Jochen C. Reif
    • , Uwe Scholz
    • , Martin Mascher
    •  & Nils Stein
  • Technical Report |

    A machine learning approach for refinement of somatic variant calls automates this process and reduces bias stemming from inter-reviewer variability.

    • Benjamin J. Ainscough
    • , Erica K. Barnell
    • , Peter Ronning
    • , Katie M. Campbell
    • , Alex H. Wagner
    • , Todd A. Fehniger
    • , Gavin P. Dunn
    • , Ravindra Uppaluri
    • , Ramaswamy Govindan
    • , Thomas E. Rohan
    • , Malachi Griffith
    • , Elaine R. Mardis
    • , S. Joshua Swamidass
    •  & Obi L. Griffith

News & Comment

  • News & Views |

    A new study identifies loss-of-function mutations in HAVCR2, which encodes TIM-3, in patients with a rare cutaneous T cell lymphoma associated with aberrant immunological activation. These mutations lead to loss of the TIM-3 immunological checkpoint, thus promoting inflammation and malignancy.

    • Karen O. Dixon
    • , Madhumita Das
    •  & Vijay K. Kuchroo
  • Correspondence |

    • Maxime Tarabichi
    • , Iñigo Martincorena
    • , Moritz Gerstung
    • , Armand M. Leroi
    • , Florian Markowetz
    • , Stefan C. Dentro
    • , Ignaty Leshchiner
    • , Moritz Gerstung
    • , Clemency Jolly
    • , Kerstin Haase
    • , Maxime Tarabichi
    • , Jeff Wintersinger
    • , Amit G. Deshwar
    • , Kaixian Yu
    • , Santiago Gonzalez
    • , Yulia Rubanova
    • , Geoff Macintyre
    • , David J. Adams
    • , Pavana Anur
    • , Rameen Beroukhim
    • , Paul C. Boutros
    • , David D. Bowtell
    • , Peter J. Campbell
    • , Shaolong Cao
    • , Elizabeth L. Christie
    • , Marek Cmero
    • , Yupeng Cun
    • , Kevin J. Dawson
    • , Jonas Demeulemeester
    • , Nilgun Donmez
    • , Ruben M. Drews
    • , Roland Eils
    • , Yu Fan
    • , Matthew Fittall
    • , Dale W. Garsed
    • , Gad Getz
    • , Gavin Ha
    • , Marcin Imielinski
    • , Lara Jerman
    • , Yuan Ji
    • , Kortine Kleinheinz
    • , Juhee Lee
    • , Henry Lee-Six
    • , Dimitri G. Livitz
    • , Salem Malikic
    • , Florian Markowetz
    • , Iñigo Martincorena
    • , Thomas J. Mitchell
    • , Ville Mustonen
    • , Layla Oesper
    • , Martin Peifer
    • , Myron Peto
    • , Benjamin J. Raphael
    • , Daniel Rosebrock
    • , S. Cenk Sahinalp
    • , Adriana Salcedo
    • , Matthias Schlesner
    • , Steven Schumacher
    • , Subhajit Sengupta
    • , Ruian Shi
    • , Seung Jun Shin
    • , Lincoln D. Stein
    • , Ignacio Vázquez-García
    • , Shankar Vembu
    • , David A. Wheeler
    • , Tsun-Po Yang
    • , Xiaotong Yao
    • , Ke Yuan
    • , Hongtu Zhu
    • , Wenyi Wang
    • , Quaid D. Morris
    • , Paul T. Spellman
    • , David C. Wedge
    • , Peter Van Loo
    • , Paul T. Spellman
    • , Quaid D. Morris
    • , Ole Christian Lingjærde
    • , David C. Wedge
    •  & Peter Van Loo
  • Correspondence |

    • Timon Heide
    • , Luis Zapata
    • , Marc J. Williams
    • , Benjamin Werner
    • , Giulio Caravagna
    • , Chris P. Barnes
    • , Trevor A. Graham
    •  & Andrea Sottoriva
  • Correspondence |

    • Lars A. Forsberg
    • , Jonatan Halvardson
    • , Edyta Rychlicka-Buniowska
    • , Marcus Danielsson
    • , Behrooz Torabi Moghadam
    • , Jonas Mattisson
    • , Chiara Rasi
    • , Hanna Davies
    • , Lars Lind
    • , Vilmantas Giedraitis
    • , Lars Lannfelt
    • , Lena Kilander
    • , Martin Ingelsson
    •  & Jan P. Dumanski

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