Mohammed Bendahmane

The Rose Genome

Latest Research

  • Article |

    This study presents OncoTreat, a framework for the prioritization of compounds targeting mechanistic tumor dependencies in individual patients.

    • Mariano J. Alvarez
    • , Prem S. Subramaniam
    • , Laura H. Tang
    • , Adina Grunn
    • , Mahalaxmi Aburi
    • , Gabrielle Rieckhof
    • , Elena V. Komissarova
    • , Elizabeth A. Hagan
    • , Lisa Bodei
    • , Paul A. Clemons
    • , Filemon S. Dela Cruz
    • , Deepti Dhall
    • , Daniel Diolaiti
    • , Douglas A. Fraker
    • , Afshin Ghavami
    • , Daniel Kaemmerer
    • , Charles Karan
    • , Mark Kidd
    • , Kyoung M. Kim
    • , Hee C. Kim
    • , Lakshmi P. Kunju
    • , Ülo Langel
    • , Zhong Li
    • , Jeeyun Lee
    • , Hai Li
    • , Virginia LiVolsi
    • , Roswitha Pfragner
    • , Allison R. Rainey
    • , Ronald B. Realubit
    • , Helen Remotti
    • , Jakob Regberg
    • , Robert Roses
    • , Anil Rustgi
    • , Antonia R. Sepulveda
    • , Stefano Serra
    • , Chanjuan Shi
    • , Xiaopu Yuan
    • , Massimo Barberis
    • , Roberto Bergamaschi
    • , Arul M. Chinnaiyan
    • , Tony Detre
    • , Shereen Ezzat
    • , Andrea Frilling
    • , Merten Hommann
    • , Dirk Jaeger
    • , Michelle K. Kim
    • , Beatrice S. Knudsen
    • , Andrew L. Kung
    • , Emer Leahy
    • , David C. Metz
    • , Jeffrey W. Milsom
    • , Young S. Park
    • , Diane Reidy-Lagunes
    • , Stuart Schreiber
    • , Kay Washington
    • , Bertram Wiedenmann
    • , Irvin Modlin
    •  & Andrea Califano
  • Technical Report |

    BayesTyper is a new probabilistic genotyping algorithm that offers superior sensitivity and accuracy relative to existing methods by using exact alignment of read k-mers to a graph representation of the reference and candidate variants.

    • Jonas Andreas Sibbesen
    • , Lasse Maretty
    •  & Anders Krogh
  • Article |

    A transcriptome-wide association study identifies associations of genetically predicted gene expression with breast cancer risk. This analysis finds 48 candidate genes implicated in breast cancer susceptibility, including 14 at novel loci.

    • Lang Wu
    • , Wei Shi
    • , Jirong Long
    • , Xingyi Guo
    • , Kyriaki Michailidou
    • , Jonathan Beesley
    • , Manjeet K. Bolla
    • , Xiao-Ou Shu
    • , Yingchang Lu
    • , Qiuyin Cai
    • , Fares Al-Ejeh
    • , Esdy Rozali
    • , Qin Wang
    • , Joe Dennis
    • , Bingshan Li
    • , Chenjie Zeng
    • , Helian Feng
    • , Alexander Gusev
    • , Richard T. Barfield
    • , Irene L. Andrulis
    • , Hoda Anton-Culver
    • , Volker Arndt
    • , Kristan J. Aronson
    • , Paul L. Auer
    • , Myrto Barrdahl
    • , Caroline Baynes
    • , Matthias W. Beckmann
    • , Javier Benitez
    • , Marina Bermisheva
    • , Carl Blomqvist
    • , Natalia V. Bogdanova
    • , Stig E. Bojesen
    • , Hiltrud Brauch
    • , Hermann Brenner
    • , Louise Brinton
    • , Per Broberg
    • , Sara Y. Brucker
    • , Barbara Burwinkel
    • , Trinidad Caldés
    • , Federico Canzian
    • , Brian D. Carter
    • , J. Esteban Castelao
    • , Jenny Chang-Claude
    • , Xiaoqing Chen
    • , Ting-Yuan David Cheng
    • , Hans Christiansen
    • , Christine L. Clarke
    • , Margriet Collée
    • , Sten Cornelissen
    • , Fergus J. Couch
    • , David Cox
    • , Angela Cox
    • , Simon S. Cross
    • , Julie M. Cunningham
    • , Kamila Czene
    • , Mary B. Daly
    • , Peter Devilee
    • , Kimberly F. Doheny
    • , Thilo Dörk
    • , Isabel dos-Santos-Silva
    • , Martine Dumont
    • , Miriam Dwek
    • , Diana M. Eccles
    • , Ursula Eilber
    • , A. Heather Eliassen
    • , Christoph Engel
    • , Mikael Eriksson
    • , Laura Fachal
    • , Peter A. Fasching
    • , Jonine Figueroa
    • , Dieter Flesch-Janys
    • , Olivia Fletcher
    • , Henrik Flyger
    • , Lin Fritschi
    • , Marike Gabrielson
    • , Manuela Gago-Dominguez
    • , Susan M. Gapstur
    • , Montserrat García-Closas
    • , Mia M. Gaudet
    • , Maya Ghoussaini
    • , Graham G. Giles
    • , Mark S. Goldberg
    • , David E. Goldgar
    • , Anna González-Neira
    • , Pascal Guénel
    • , Eric Hahnen
    • , Christopher A. Haiman
    • , Niclas Håkansson
    • , Per Hall
    • , Emily Hallberg
    • , Ute Hamann
    • , Patricia Harrington
    • , Alexander Hein
    • , Belynda Hicks
    • , Peter Hillemanns
    • , Antoinette Hollestelle
    • , Robert N. Hoover
    • , John L. Hopper
    • , Guanmengqian Huang
    • , Keith Humphreys
    • , David J. Hunter
    • , Anna Jakubowska
    • , Wolfgang Janni
    • , Esther M. John
    • , Nichola Johnson
    • , Kristine Jones
    • , Michael E. Jones
    • , Audrey Jung
    • , Rudolf Kaaks
    • , Michael J. Kerin
    • , Elza Khusnutdinova
    • , Veli-Matti Kosma
    • , Vessela N. Kristensen
    • , Diether Lambrechts
    • , Loic Le Marchand
    • , Jingmei Li
    • , Sara Lindström
    • , Jolanta Lissowska
    • , Wing-Yee Lo
    • , Sibylle Loibl
    • , Jan Lubinski
    • , Craig Luccarini
    • , Michael P. Lux
    • , Robert J. MacInnis
    • , Tom Maishman
    • , Ivana Maleva Kostovska
    • , Arto Mannermaa
    • , JoAnn E. Manson
    • , Sara Margolin
    • , Dimitrios Mavroudis
    • , Hanne Meijers-Heijboer
    • , Alfons Meindl
    • , Usha Menon
    • , Jeffery Meyer
    • , Anna Marie Mulligan
    • , Susan L. Neuhausen
    • , Heli Nevanlinna
    • , Patrick Neven
    • , Sune F. Nielsen
    • , Børge G. Nordestgaard
    • , Olufunmilayo I. Olopade
    • , Janet E. Olson
    • , Håkan Olsson
    • , Paolo Peterlongo
    • , Julian Peto
    • , Dijana Plaseska-Karanfilska
    • , Ross Prentice
    • , Nadege Presneau
    • , Katri Pylkäs
    • , Brigitte Rack
    • , Paolo Radice
    • , Nazneen Rahman
    • , Gad Rennert
    • , Hedy S. Rennert
    • , Valerie Rhenius
    • , Atocha Romero
    • , Jane Romm
    • , Anja Rudolph
    • , Emmanouil Saloustros
    • , Dale P. Sandler
    • , Elinor J. Sawyer
    • , Marjanka K. Schmidt
    • , Rita K. Schmutzler
    • , Andreas Schneeweiss
    • , Rodney J. Scott
    • , Christopher G. Scott
    • , Sheila Seal
    • , Mitul Shah
    • , Martha J. Shrubsole
    • , Ann Smeets
    • , Melissa C. Southey
    • , John J. Spinelli
    • , Jennifer Stone
    • , Harald Surowy
    • , Anthony J. Swerdlow
    • , Rulla M. Tamimi
    • , William Tapper
    • , Jack A. Taylor
    • , Mary Beth Terry
    • , Daniel C. Tessier
    • , Abigail Thomas
    • , Kathrin Thöne
    • , Rob A. E. M. Tollenaar
    • , Diana Torres
    • , Thérèse Truong
    • , Michael Untch
    • , Celine Vachon
    • , David Van Den Berg
    • , Daniel Vincent
    • , Quinten Waisfisz
    • , Clarice R. Weinberg
    • , Camilla Wendt
    • , Alice S. Whittemore
    • , Hans Wildiers
    • , Walter C. Willett
    • , Robert Winqvist
    • , Alicja Wolk
    • , Lucy Xia
    • , Xiaohong R. Yang
    • , Argyrios Ziogas
    • , Elad Ziv
    • , Alison M. Dunning
    • , Paul D. P. Pharoah
    • , Jacques Simard
    • , Roger L. Milne
    • , Stacey L. Edwards
    • , Peter Kraft
    • , Douglas F. Easton
    • , Georgia Chenevix-Trench
    •  & Wei Zheng
  • Article |

    The roles of of Gorab in the Golgi and in centriole structure and function can be separated mutationally in Drosophila. Complexed to Sas6 in the centriolar cartwheel, Gorab is essential for mitotic centriole duplication in the fly.

    • Levente Kovacs
    • , Jennifer Chao-Chu
    • , Sandra Schneider
    • , Marco Gottardo
    • , George Tzolovsky
    • , Nikola S. Dzhindzhev
    • , Maria Giovanna Riparbelli
    • , Giuliano Callaini
    •  & David M. Glover
  • Letter |

    A large meta-analysis combining genome-wide and custom high-density genotyping array data identifies 63 new susceptibility loci for prostate cancer, enhancing fine-mapping efforts and providing insights into the underlying biology.

    • Fredrick R. Schumacher
    • , Ali Amin Al Olama
    • , Sonja I. Berndt
    • , Sara Benlloch
    • , Mahbubl Ahmed
    • , Edward J. Saunders
    • , Tokhir Dadaev
    • , Daniel Leongamornlert
    • , Ezequiel Anokian
    • , Clara Cieza-Borrella
    • , Chee Goh
    • , Mark N. Brook
    • , Xin Sheng
    • , Laura Fachal
    • , Joe Dennis
    • , Jonathan Tyrer
    • , Kenneth Muir
    • , Artitaya Lophatananon
    • , Victoria L. Stevens
    • , Susan M. Gapstur
    • , Brian D. Carter
    • , Catherine M. Tangen
    • , Phyllis J. Goodman
    • , Ian M. Thompson Jr
    • , Jyotsna Batra
    • , Suzanne Chambers
    • , Leire Moya
    • , Judith Clements
    • , Lisa Horvath
    • , Wayne Tilley
    • , Gail P. Risbridger
    • , Henrik Gronberg
    • , Markus Aly
    • , Tobias Nordström
    • , Paul Pharoah
    • , Nora Pashayan
    • , Johanna Schleutker
    • , Teuvo L. J. Tammela
    • , Csilla Sipeky
    • , Anssi Auvinen
    • , Demetrius Albanes
    • , Stephanie Weinstein
    • , Alicja Wolk
    • , Niclas Håkansson
    • , Catharine M. L. West
    • , Alison M. Dunning
    • , Neil Burnet
    • , Lorelei A. Mucci
    • , Edward Giovannucci
    • , Gerald L. Andriole
    • , Olivier Cussenot
    • , Géraldine Cancel-Tassin
    • , Stella Koutros
    • , Laura E. Beane Freeman
    • , Karina Dalsgaard Sorensen
    • , Torben Falck Orntoft
    • , Michael Borre
    • , Lovise Maehle
    • , Eli Marie Grindedal
    • , David E. Neal
    • , Jenny L. Donovan
    • , Freddie C. Hamdy
    • , Richard M. Martin
    • , Ruth C. Travis
    • , Tim J. Key
    • , Robert J. Hamilton
    • , Neil E. Fleshner
    • , Antonio Finelli
    • , Sue Ann Ingles
    • , Mariana C. Stern
    • , Barry S. Rosenstein
    • , Sarah L. Kerns
    • , Harry Ostrer
    • , Yong-Jie Lu
    • , Hong-Wei Zhang
    • , Ninghan Feng
    • , Xueying Mao
    • , Xin Guo
    • , Guomin Wang
    • , Zan Sun
    • , Graham G. Giles
    • , Melissa C. Southey
    • , Robert J. MacInnis
    • , Liesel M. FitzGerald
    • , Adam S. Kibel
    • , Bettina F. Drake
    • , Ana Vega
    • , Antonio Gómez-Caamaño
    • , Robert Szulkin
    • , Martin Eklund
    • , Manolis Kogevinas
    • , Javier Llorca
    • , Gemma Castaño-Vinyals
    • , Kathryn L. Penney
    • , Meir Stampfer
    • , Jong Y. Park
    • , Thomas A. Sellers
    • , Hui-Yi Lin
    • , Janet L. Stanford
    • , Cezary Cybulski
    • , Dominika Wokolorczyk
    • , Jan Lubinski
    • , Elaine A. Ostrander
    • , Milan S. Geybels
    • , Børge G. Nordestgaard
    • , Sune F. Nielsen
    • , Maren Weischer
    • , Rasmus Bisbjerg
    • , Martin Andreas Røder
    • , Peter Iversen
    • , Hermann Brenner
    • , Katarina Cuk
    • , Bernd Holleczek
    • , Christiane Maier
    • , Manuel Luedeke
    • , Thomas Schnoeller
    • , Jeri Kim
    • , Christopher J. Logothetis
    • , Esther M. John
    • , Manuel R. Teixeira
    • , Paula Paulo
    • , Marta Cardoso
    • , Susan L. Neuhausen
    • , Linda Steele
    • , Yuan Chun Ding
    • , Kim De Ruyck
    • , Gert De Meerleer
    • , Piet Ost
    • , Azad Razack
    • , Jasmine Lim
    • , Soo-Hwang Teo
    • , Daniel W. Lin
    • , Lisa F. Newcomb
    • , Davor Lessel
    • , Marija Gamulin
    • , Tomislav Kulis
    • , Radka Kaneva
    • , Nawaid Usmani
    • , Sandeep Singhal
    • , Chavdar Slavov
    • , Vanio Mitev
    • , Matthew Parliament
    • , Frank Claessens
    • , Steven Joniau
    • , Thomas Van den Broeck
    • , Samantha Larkin
    • , Paul A. Townsend
    • , Claire Aukim-Hastie
    • , Manuela Gago Dominguez
    • , Jose Esteban Castelao
    • , Maria Elena Martinez
    • , Monique J. Roobol
    • , Guido Jenster
    • , Ron H. N. van Schaik
    • , Florence Menegaux
    • , Thérèse Truong
    • , Yves Akoli Koudou
    • , Jianfeng Xu
    • , Kay-Tee Khaw
    • , Lisa Cannon-Albright
    • , Hardev Pandha
    • , Agnieszka Michael
    • , Stephen N. Thibodeau
    • , Shannon K. McDonnell
    • , Daniel J. Schaid
    • , Sara Lindstrom
    • , Constance Turman
    • , Jing Ma
    • , David J. Hunter
    • , Elio Riboli
    • , Afshan Siddiq
    • , Federico Canzian
    • , Laurence N. Kolonel
    • , Loic Le Marchand
    • , Robert N. Hoover
    • , Mitchell J. Machiela
    • , Zuxi Cui
    • , Peter Kraft
    • , Christopher I. Amos
    • , David V. Conti
    • , Douglas F. Easton
    • , Fredrik Wiklund
    • , Stephen J. Chanock
    • , Brian E. Henderson
    • , Zsofia Kote-Jarai
    • , Christopher A. Haiman
    •  & Rosalind A. Eeles
  • Letter |

    This large, multi-ethnic genome-wide association study identifies 97 loci significantly associated with atrial fibrillation. These loci are enriched for genes involved in cardiac development, electrophysiology, structure and contractile function.

    • Carolina Roselli
    • , Mark D. Chaffin
    • , Lu-Chen Weng
    • , Stefanie Aeschbacher
    • , Gustav Ahlberg
    • , Christine M. Albert
    • , Peter Almgren
    • , Alvaro Alonso
    • , Christopher D. Anderson
    • , Krishna G. Aragam
    • , Dan E. Arking
    • , John Barnard
    • , Traci M. Bartz
    • , Emelia J. Benjamin
    • , Nathan A. Bihlmeyer
    • , Joshua C. Bis
    • , Heather L. Bloom
    • , Eric Boerwinkle
    • , Erwin B. Bottinger
    • , Jennifer A. Brody
    • , Hugh Calkins
    • , Archie Campbell
    • , Thomas P. Cappola
    • , John Carlquist
    • , Daniel I. Chasman
    • , Lin Y. Chen
    • , Yii-Der Ida Chen
    • , Eue-Keun Choi
    • , Seung Hoan Choi
    • , Ingrid E. Christophersen
    • , Mina K. Chung
    • , John W. Cole
    • , David Conen
    • , James Cook
    • , Harry J. Crijns
    • , Michael J. Cutler
    • , Scott M. Damrauer
    • , Brian R. Daniels
    • , Dawood Darbar
    • , Graciela Delgado
    • , Joshua C. Denny
    • , Martin Dichgans
    • , Marcus Dörr
    • , Elton A. Dudink
    • , Samuel C. Dudley
    • , Nada Esa
    • , Tonu Esko
    • , Markku Eskola
    • , Diane Fatkin
    • , Stephan B. Felix
    • , Ian Ford
    • , Oscar H. Franco
    • , Bastiaan Geelhoed
    • , Raji P. Grewal
    • , Vilmundur Gudnason
    • , Xiuqing Guo
    • , Namrata Gupta
    • , Stefan Gustafsson
    • , Rebecca Gutmann
    • , Anders Hamsten
    • , Tamara B. Harris
    • , Caroline Hayward
    • , Susan R. Heckbert
    • , Jussi Hernesniemi
    • , Lynne J. Hocking
    • , Albert Hofman
    • , Andrea R. V. R. Horimoto
    • , Jie Huang
    • , Paul L. Huang
    • , Jennifer Huffman
    • , Erik Ingelsson
    • , Esra Gucuk Ipek
    • , Kaoru Ito
    • , Jordi Jimenez-Conde
    • , Renee Johnson
    • , J. Wouter Jukema
    • , Stefan Kääb
    • , Mika Kähönen
    • , Yoichiro Kamatani
    • , John P. Kane
    • , Adnan Kastrati
    • , Sekar Kathiresan
    • , Petra Katschnig-Winter
    • , Maryam Kavousi
    • , Thorsten Kessler
    • , Bas L. Kietselaer
    • , Paulus Kirchhof
    • , Marcus E. Kleber
    • , Stacey Knight
    • , Jose E. Krieger
    • , Michiaki Kubo
    • , Lenore J. Launer
    • , Jari Laurikka
    • , Terho Lehtimäki
    • , Kirsten Leineweber
    • , Rozenn N. Lemaitre
    • , Man Li
    • , Hong Euy Lim
    • , Henry J. Lin
    • , Honghuang Lin
    • , Lars Lind
    • , Cecilia M. Lindgren
    • , Marja-Liisa Lokki
    • , Barry London
    • , Ruth J. F. Loos
    • , Siew-Kee Low
    • , Yingchang Lu
    • , Leo-Pekka Lyytikäinen
    • , Peter W. Macfarlane
    • , Patrik K. Magnusson
    • , Anubha Mahajan
    • , Rainer Malik
    • , Alfredo J. Mansur
    • , Gregory M. Marcus
    • , Lauren Margolin
    • , Kenneth B. Margulies
    • , Winfried März
    • , David D. McManus
    • , Olle Melander
    • , Sanghamitra Mohanty
    • , Jay A. Montgomery
    • , Michael P. Morley
    • , Andrew P. Morris
    • , Martina Müller-Nurasyid
    • , Andrea Natale
    • , Saman Nazarian
    • , Benjamin Neumann
    • , Christopher Newton-Cheh
    • , Maartje N. Niemeijer
    • , Kjell Nikus
    • , Peter Nilsson
    • , Raymond Noordam
    • , Heidi Oellers
    • , Morten S. Olesen
    • , Marju Orho-Melander
    • , Sandosh Padmanabhan
    • , Hui-Nam Pak
    • , Guillaume Paré
    • , Nancy L. Pedersen
    • , Joanna Pera
    • , Alexandre Pereira
    • , David Porteous
    • , Bruce M. Psaty
    • , Sara L. Pulit
    • , Clive R. Pullinger
    • , Daniel J. Rader
    • , Lena Refsgaard
    • , Marta Ribasés
    • , Paul M. Ridker
    • , Michiel Rienstra
    • , Lorenz Risch
    • , Dan M. Roden
    • , Jonathan Rosand
    • , Michael A. Rosenberg
    • , Natalia Rost
    • , Jerome I. Rotter
    • , Samir Saba
    • , Roopinder K. Sandhu
    • , Renate B. Schnabel
    • , Katharina Schramm
    • , Heribert Schunkert
    • , Claudia Schurman
    • , Stuart A. Scott
    • , Ilkka Seppälä
    • , Christian Shaffer
    • , Svati Shah
    • , Alaa A. Shalaby
    • , Jaemin Shim
    • , M. Benjamin Shoemaker
    • , Joylene E. Siland
    • , Juha Sinisalo
    • , Moritz F. Sinner
    • , Agnieszka Slowik
    • , Albert V. Smith
    • , Blair H. Smith
    • , J. Gustav Smith
    • , Jonathan D. Smith
    • , Nicholas L. Smith
    • , Elsayed Z. Soliman
    • , Nona Sotoodehnia
    • , Bruno H. Stricker
    • , Albert Sun
    • , Han Sun
    • , Jesper H. Svendsen
    • , Toshihiro Tanaka
    • , Kahraman Tanriverdi
    • , Kent D. Taylor
    • , Maris Teder-Laving
    • , Alexander Teumer
    • , Sébastien Thériault
    • , Stella Trompet
    • , Nathan R. Tucker
    • , Arnljot Tveit
    • , Andre G. Uitterlinden
    • , Pim Van Der Harst
    • , Isabelle C. Van Gelder
    • , David R. Van Wagoner
    • , Niek Verweij
    • , Efthymia Vlachopoulou
    • , Uwe Völker
    • , Biqi Wang
    • , Peter E. Weeke
    • , Bob Weijs
    • , Raul Weiss
    • , Stefan Weiss
    • , Quinn S. Wells
    • , Kerri L. Wiggins
    • , Jorge A. Wong
    • , Daniel Woo
    • , Bradford B. Worrall
    • , Pil-Sung Yang
    • , Jie Yao
    • , Zachary T. Yoneda
    • , Tanja Zeller
    • , Lingyao Zeng
    • , Steven A. Lubitz
    • , Kathryn L. Lunetta
    •  & Patrick T. Ellinor

News & Comment

  • News & Views |

    Roses have held an attraction for people all over the world as ornamental plants. Now genome sequencing of the highly heterozygous Rosa chinensis and resequencing of major genotypes open the door to a greater understanding of rose evolutionary history and the regulatory mechanisms determining rose flower color and scent.

    • Qing Xu
    •  & Zhong-Jian Liu
  • Editorial |

    To celebrate the Rosa genomes, we invite you to imagine ways to make rosy data as well loved as the roses themselves. This is an opportunity for data modeling and new discoveries from reanalysis, as well as for data display to feed public interest in the science and culture of flowers.

  • News & Views |

    The ability to visualize and study the 3D folding of chromosomes in cells has been propelled forward by several major technological advances in the past two decades. Two new studies now further expand the scientific toolbox for studying chromosome conformation by providing novel methodologies for accurate mapping of genome topology and predicting the topological effects of genomic structural variation.

    • Ralph Stadhouders
  • Editorial |

    With new ways to examine the effects of mutations on gene expression within the 3D genome and increased emphasis on finding these variants by sequencing whole genomes, we would really like to know more about the rules that govern noncoding and regulatory sequences.

  • News & Views |

    The triplet code underpins analyses of rare and de novo mutations in exome sequencing data, but analysis of the noncoding genome is much more challenging. A new analytical framework for common, complex diseases highlights the need for very large samples to overcome the unavoidable multiple-testing burden and hence provides preemptive warnings against underpowered studies.

    • Naomi R. Wray
    •  & Jacob Gratten

About the Journal

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