Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation

  • Blagoje Soskic
  • Eddie Cano-Gamez
  • Gosia Trynka

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  • Recent work has highlighted a lack of diversity in genomic studies. However, less attention has been given to epigenomics. Here, we show that epigenomic studies are lacking in diversity and propose several solutions to address this problem.

    • Charles E. Breeze
    • Stephan Beck
    • Nora Franceschini
  • Calls for diversity in genomics have motivated new global research collaborations across institutions with highly imbalanced resources. We describe practical lessons we have learned so far from designing multidisciplinary international research and capacity-building programs that prioritize equity in two intertwined programs — the NeuroGAP-Psychosis research study and GINGER training program — spanning institutions in Ethiopia, Kenya, South Africa, Uganda and the United States.

    • Alicia R. Martin
    • Rocky E. Stroud II
    • Lori B. Chibnik
  • To leverage the genetic diversity in Nigeria, we established the Non-Communicable Diseases Genetic Heritage Study (NCD-GHS) consortium to help produce a comprehensive catalog of human genetic variation in Nigeria and assess the burden and etiological characteristics of non-communicable diseases in 100,000 adults in Nigeria.

    • Segun Fatumo
    • Aminu Yakubu
    • Abasi Ene-Obong
  • The Cardiometabolic Disorders in African-Ancestry Populations (CARDINAL) study site is a well-powered, first-of-its-kind resource for developing, refining and validating methods for research into polygenic risk scores that accounts for local ancestry, to improve risk prediction in diverse populations.

    • Clement A. Adebamowo
    • Adebowale Adeyemo
    • Sally N. Adebamowo
  • Widespread enthusiasm about potential contributions of genome-edited crops to address climate change, food security, nutrition and health, environmental sustainability and diversification of agriculture is dampened by concerns about the associated risks. Analysis of the top seven risks of genome-edited crops finds that the scientific risks are comparable to those of accepted, past and current breeding methods, but failure to address regulatory, legal and trade framework, and the granting of social license, squanders the potential benefits.

    • Kevin V. Pixley
    • Jose B. Falck-Zepeda
    • Neal Gutterson
  • To do good science, we need to include diverse perspectives, work across disciplines and think outside the box while reminding ourselves that our goal as scientists is to serve humanity. I am sharing my story to encourage others to trust their gut feelings and to have the courage to see what everyone sees, but think what no one has thought.

    • Rana Dajani
    World View

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