Yuxian Liu and Wei Yao

Sugarcane genome

Latest Research

  • Letter |

    Activating HER2 mutations are shown to confer resistance to ER-directed therapies in patients with ER+ metastatic breast cancer. Drug resistance caused by HER2 mutations was overcome by combining ER-directed therapy with a HER2 kinase inhibitor.

    • Utthara Nayar
    • , Ofir Cohen
    • , Christian Kapstad
    • , Michael S. Cuoco
    • , Adrienne G. Waks
    • , Seth A. Wander
    • , Corrie Painter
    • , Samuel Freeman
    • , Nicole S. Persky
    • , Lori Marini
    • , Karla Helvie
    • , Nelly Oliver
    • , Orit Rozenblatt-Rosen
    • , Cynthia X. Ma
    • , Aviv Regev
    • , Eric P. Winer
    • , Nancy U. Lin
    •  & Nikhil Wagle
  • Article |

    This study leverages coding variation observed among 123,136 individuals to create a detailed map of constrained coding regions in the human genome. This map may help identify critical regions within genes that, when mutated, cause embryonic lethality or severe developmental phenotypes.

    • James M. Havrilla
    • , Brent S. Pedersen
    • , Ryan M. Layer
    •  & Aaron R. Quinlan
  • Article |

    This study shows that immune-related genes are primed for transcription by proximal lncRNAs. One such lncRNA, UMLILO, directs the WDR5–MLL1 complex to CXCL chemokine promoters, facilitating H3K4me3 deposition.

    • Stephanie Fanucchi
    • , Ezio T. Fok
    • , Emiliano Dalla
    • , Youtaro Shibayama
    • , Kathleen Börner
    • , Erin Y. Chang
    • , Stoyan Stoychev
    • , Maxim Imakaev
    • , Dirk Grimm
    • , Kevin C. Wang
    • , Guoliang Li
    • , Wing-Kin Sung
    •  & Musa M. Mhlanga
  • Letter |

    Analysis of mutational asymmetry with respect to the direction of replication and transcription suggests that error-prone damage bypass on the lagging strand has a major role in human germline and cancer mutations.

    • Vladimir B. Seplyarskiy
    • , Evgeny E. Akkuratov
    • , Natalia Akkuratova
    • , Maria A. Andrianova
    • , Sergey I. Nikolaev
    • , Georgii A. Bazykin
    • , Igor Adameyko
    •  & Shamil R. Sunyaev
  • Brief Communication |

    The long noncoding RNA SCHLAP1 has been reported to act by depleting the SWI/SNF complex from genomic sites, but new data show that SWI/SNF remains localized to chromatin in the presence of SCHLAP1, suggesting that SCHLAP1 may act independently of SWI/SNF.

    • Jesse R. Raab
    • , Keriayn N. Smith
    • , Camarie C. Spear
    • , Carl J. Manner
    • , J. Mauro Calabrese
    •  & Terry Magnuson
  • Analysis |

    Including patient-specific information about nearby somatic and germline alterations improves the accuracy of neoantigen prediction, potentially impacting cancer vaccine design.

    • Jasreet Hundal
    • , Susanna Kiwala
    • , Yang-Yang Feng
    • , Connor J. Liu
    • , Ramaswamy Govindan
    • , William C. Chapman
    • , Ravindra Uppaluri
    • , S. Joshua Swamidass
    • , Obi L. Griffith
    • , Elaine R. Mardis
    •  & Malachi Griffith

News & Comment

  • Correspondence |

    • Weiyin Zhou
    • , Mitchell J. Machiela
    • , Neal D. Freedman
    • , Nathaniel Rothman
    • , Nuria Malats
    • , Casey Dagnall
    • , Neil Caporaso
    • , Lauren T. Teras
    • , Mia M. Gaudet
    • , Susan M. Gapstur
    • , Victoria L. Stevens
    • , Kevin B. Jacobs
    • , Joshua Sampson
    • , Demetrius Albanes
    • , Stephanie Weinstein
    • , Jarmo Virtamo
    • , Sonja Berndt
    • , Robert N. Hoover
    • , Amanda Black
    • , Debra Silverman
    • , Jonine Figueroa
    • , Montserrat Garcia-Closas
    • , Francisco X. Real
    • , Julie Earl
    • , Gaelle Marenne
    • , Benjamin Rodriguez-Santiago
    • , Margaret Karagas
    • , Alison Johnson
    • , Molly Schwenn
    • , Xifeng Wu
    • , Jian Gu
    • , Yuanqing Ye
    • , Amy Hutchinson
    • , Margaret Tucker
    • , Luis A. Perez-Jurado
    • , Michael Dean
    • , Meredith Yeager
    •  & Stephen J. Chanock
  • News & Views |

    The genomes for essentially all worm parasites of humans are in hand thanks to a new study. Now we have to use them.

    • Paul W. Sternberg
  • Editorial |

    Well-designed science education via social media may help to reach a larger group of audiences with the aim of reducing the boundaries between researchers and the public. This may, in turn, move basic science toward translational improvement in human health and agriculture.

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