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The hormone oxytocin is important for labor and lactation in mammals, and giving birth was known to improve spatial memory in rats. Tomizawa and colleagues now report that intra-cerebroventricular injections of oxytocin improve spatial memory in mice that have never been pregnant, while an oxytocin antagonist inhibits the memory improvement normally seen in mice with multiple litters. Oxytocin also facilitates long-lasting, long-term potentiation in hippocampal slices. The authors suggest that oxytocin-associated memory improvement could help mothers remember the location of food sources and thus improve the survival of their young. Photograph courtesy of PhotoResearchers. See pages 327 and 153.
Giving birth improves spatial memory in rodents. A new study shows that oxytocin, which triggers birth and milk release, activates a signaling cascade involved in learning, and that this hormone is necessary and sufficient for memory improvement in mice that have had litters.
Transplantation studies using mouse models for Alzheimer's disease reveal that diffusible Aβ peptide is sufficient for amyloid plaque formation but is influenced by the local environment.
Primary auditory cortex neurons are now shown to respond to the probability of a sound's occurrence--perhaps a correlate of the mismatch negativity implicated in novelty detection.
A new study shows that activity in the superior colliculus encodes the distance to the goal of the orienting movement, not the particular saccade or saccades used to get there.