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Volume 6 Issue 4, April 2003

The hormone oxytocin is important for labor and lactation in mammals, and giving birth was known to improve spatial memory in rats. Tomizawa and colleagues now report that intra-cerebroventricular injections of oxytocin improve spatial memory in mice that have never been pregnant, while an oxytocin antagonist inhibits the memory improvement normally seen in mice with multiple litters. Oxytocin also facilitates long-lasting, long-term potentiation in hippocampal slices. The authors suggest that oxytocin-associated memory improvement could help mothers remember the location of food sources and thus improve the survival of their young. Photograph courtesy of PhotoResearchers. See pages 327 and 153.

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