Volume 3 Issue 6, June 2000

Volume 3 Issue 6

McKernan et al. use transgenic mice with a point mutation in a GABAA receptor subunit to dissociate the anxiolytic actions of diazepam (shown here) and related drugs from their sedative effects. They also describe a new ligand for the benzodiazepine binding site, which in normal mice produces anxiolytic effects without sedation. Photo courtesy of Sharon Freeman. See pages 529.529 and 587.

Editorial

News and Views

  • News & Views |

    High-resolution analysis of immature receptive fields in lateral geniculate neurons suggests that transient oriented receptive fields in the thalamus may contribute to the development of orientation selectivity in visual cortex.

    • S. Murray Sherman
  • News & Views |

    Satake et al. show that glutamate release in the cerebellum causes heterosynaptic depression of GABA release and that AMPA receptors act presynaptically to mediate this phenomenon.

    • Roger A. Nicoll
    • , Matthew Frerking
    •  & Dietmar Schmitz
  • News & Views |

    Anxiolytic-like and sedative effects of benzodiazepines can be dissociated in mice with a mutant GABAA receptor α1 subunit gene or in wild-type mice by a new benzodiazepine-site ligand.

    • Laurence H. Tecott
  • News & Views |

    The isolated vertebrate brainstem can produce not only the normal breathing rhythm, but also sighs and gasps. All three patterns may involve the same neural circuit.

    • Jack L. Feldman
    •  & Paul A. Gray

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