Volume 3 Issue 12, December 2000

Volume 3 Issue 12

Betarbet et al. report that chronic administration of rotenone, a widely used pesticide, can induce the major features of Parkinson's disease in rats, including the accumulation of Lewy bodies in the substantia nigra and other brain-stem nuclei. See pages 1227 and 1301.


News and Views

  • News & Views |

    Environmental factors are thought to be an important cause of Parkinson's disease. A new study shows that rats chronically treated with the mitochondrial inhibitor rotenone, a common pesticide, develop neuropathological and behavioral symptoms of Parkinsonism.

    • Benoit I. Giasson
    •  & Virginia M.-Y. Lee
  • News & Views |

    Llano and colleagues show that calcium released from presynaptic stores can drive simultaneous release of multiple vesicles at fast inhibitory synapses in the cerebellum.

    • Matthew A. Xu-Friedman
    •  & Wade G. Regehr
  • News & Views |

    A recent Nature paper on mice lacking the Na+ channel BNC1 shows that this channel is essential for neuronal touch receptor function and may be part of a mechanosensory complex.

    • Monica Driscoll
    •  & Nektarios Tavernarakis
  • News & Views |

    Practicing a procedural memory task does not improve performance until hours later. Two new studies show that sleep is absolutely necessary for this memory consolidation.

    • Pierre Maquet

Brief Communication

Book Reviews