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The diffusible signal Sonic Hedgehog (Shh) controls cell type specification in the ventral spinal cord. Litingtung and Chiang now show that some defects due to the lack of Shh are rescued by deleting the transcription factor Gli3, suggesting that Shh works by inactivating Gli3.
A new study demonstrates a link between neurotransmitter secretion and reuptake by showing that syntaxin 1A also interacts with—and regulates—GAT1 GABA transporters.
Overexpression of an activity-dependent protein, CPG15, in Xenopus tectal cells promotes growth of tectal dendrites and retinal axons, and may coordinate their development.
A recent study suggests that functional brain imaging combined with behavioral tests can identify preclinical changes that may predict Alzheimer's disease.
