Volume 3 Issue 10, October 2000

Volume 3 Issue 10

Vescovi and colleagues demonstrate that isolated and clonally derived neural stem cells can become skeletal myotubes in vitro and in vivo. Clonal neural stem cells from the brain of adult mice that constitutively express β-galactosidase were cocultured with C2C12 myoblast cells. Stem cells that have differentiated into muscle are labeled both with an anti-β-galactosidase antibody (red) and with an anti-myosin antibody (green); areas of overlap are yellow. Nuclei are labeled with DAPI (blue). See pages 961 and 986.

Editorial

Letters to Editor

News and Views

  • News & Views |

    The diffusible signal Sonic Hedgehog (Shh) controls cell type specification in the ventral spinal cord. Litingtung and Chiang now show that some defects due to the lack of Shh are rescued by deleting the transcription factor Gli3, suggesting that Shh works by inactivating Gli3.

    • Donna Stone
    •  & Arnon Rosenthal
  • News & Views |

    A new study demonstrates a link between neurotransmitter secretion and reuptake by showing that syntaxin 1A also interacts with—and regulates—GAT1 GABA transporters.

    • Randy D. Blakely
    •  & Uhna Sung
  • News & Views |

    Overexpression of an activity-dependent protein, CPG15, in Xenopus tectal cells promotes growth of tectal dendrites and retinal axons, and may coordinate their development.

    • Susan Udin

Book Review

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