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Volume 25 Issue 9, September 2022

Researcher’s sex influences mouse studies

Georgiou et al. find that the sex of the person performing experiments affects mouse behavior, including responses to stress and ketamine. This effect is mediated by CRF neurons in the entorhinal cortex that project to CA1.

See Georgiou et al.

Image: Marina Corral Spence. Cover Design: Marina Corral Spence.

Comment

  • Although issues surrounding diversity and inclusion in science are global, distinctive region-specific socioeconomic factors and operational biases interact to widen the opportunity gap and exacerbate the isolation of specific groups of disadvantaged scientists on the global stage. This commentary reviews the issues currently faced by the Latin American (neuro)science community and outlines key actions on multiple fronts to overcome the barriers impeding their global inclusion, visibility and success.

    • Ana Silva
    • Keerthana Iyer
    • Carmen Sandi
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  • We studied how the sex of human experimenters affected mouse behaviors and brain functions under normal conditions and in the context of ketamine administration. Identifying such unknown unknowns was critical to understanding how, specifically and quantitatively, they affected experimental outcomes, which led to fresh insight into ketamine’s mechanism as an antidepressant drug.

    Research Briefing
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Brief Communications

  • Fiber photometry can record brain dynamics, but the biological source of the signal remains unclear. The authors report that fiber photometry in striatum mainly reflects nonsomatic, and not somatic or spiking-related, changes in calcium.

    • Alex A. Legaria
    • Bridget A. Matikainen-Ankney
    • Alexxai V. Kravitz
    Brief Communication
  • The structural and functional development of the human cerebellum is not well known. The cerebellum shows a gradient of tissue properties across its lobules, each of which develops at a unique rate and closely follows changes in function across childhood.

    • Xingyu Liu
    • Federico d’Oleire Uquillas
    • Jesse Gomez
    Brief Communication
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