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Volume 24 Issue 10, October 2021

EEG marker for seizure onset zone

The primary treatment for drug-resistant epilepsy is surgical removal of brain regions causing seizures, but outcomes are poor because there is no biomarker of epileptogenicity. Li and colleagues developed an EEG marker, neural fragility, that pinpoints brain regions likely to cause seizures. The cover art illustrates fragile (orange) epileptogenic neurons on the chalice triggering a seizure, represented by flames and smoke, resulting in a hyperactive EEG (light blue traces).

See A. Li et al.

Image: Shawna R. Snyder, M.A. Cover Design: Marina Corral Spence.


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Research Highlights

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News & Views

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  • Visually guided behavior begins with inputs to sensory cortices, but the decision to initiate actions engages the frontal cortex. A new study dissects a microcircuit for visual-to-motor transformation in the anterior cingulate cortex of the mouse with implications for impulsivity and disease states.

    • Heather K. Ortega
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  • In this Perspective, Tononi and colleagues argue that while knowledge of elementary mechanisms is enough to predict everything about the dynamics of a system, only the analysis of causal structures can provide a coherent account of ‘what caused what’.

    • Matteo Grasso
    • Larissa Albantakis
    • Giulio Tononi
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Review Articles

  • Multiphoton holographic optogenetics is opening the era of ‘tailored’ optogenetics. The authors review the underlying technology and discuss how it can be used to bridge the gap between experimental and theoretical neuroscience.

    • Hillel Adesnik
    • Lamiae Abdeladim
    Review Article
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  • Using single-cell RNA sequencing and spatial transcriptomics, Hasel et al. uncover complex reactive astrocyte subtypes that occupy distinct areas of the brain. They find two super-responders expressing unique genes in strategic locations in the brain.

    • Philip Hasel
    • Indigo V. L. Rose
    • Shane A. Liddelow
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