Volume 23 Issue 2, February 2020

Volume 23 Issue 2

White matter pathways in marmosets

Myelinated axonal bundles in the brain's white matter form the roadmap that enables neuronal communication between many brain regions. Previous attempts at charting fiber bundles in the primate brain have fallen short of providing a complete whole-brain description, due to challenges in mapping pathways with sufficient spatial resolution. In this issue, Liu and colleagues present an ultra-high-resolution, dMRI-based resource for studying white matter pathways and connectivity in the marmoset brain. The resource reveals previously hidden details of primate white matter and consists of comprehensive tools to facilitate mapping marmoset brain and to understand its wiring principles.

See Liu, C. et al.

News & Views

  • News & Views |

    Recent findings unveil a viral-like mechanism for the transmission of synaptic plasticity signals involving the activity-regulated cytoskeleton-associated protein (Arc). Arc forms capsid-like particles that package RNA and are transported across synapses. Here Erlendsson et al. present a high-resolution structural representation of Arc capsids, enabling deeper analysis of their function.

    • Vivian Budnik
    •  & Travis Thomson
  • News & Views |

    Rewards direct behavioral adaptation through midbrain dopamine signaling, though the timing of those effects is often ambiguous. Lee and colleagues find that different subpopulations of dopamine neurons obey similar constraints, indirectly regulating reward-related behavior through learning mechanisms restricted to a brief time window following reward.

    • Luke T. Coddington

Review Articles

Brief Communications

  • Brief Communication |

    Kodama et al. show that microglia from male and female adult mice have distinct microRNA profiles and that loss of microglial microRNAs leads to sex-specific changes in the microglial transcriptome and tau pathology.

    • Lay Kodama
    • , Elmer Guzman
    • , Jon I. Etchegaray
    • , Yaqiao Li
    • , Faten A. Sayed
    • , Lu Zhou
    • , Yungui Zhou
    • , Lihong Zhan
    • , David Le
    • , Joe C. Udeochu
    • , Claire D. Clelland
    • , Zuolin Cheng
    • , Guoqiang Yu
    • , Qingyun Li
    • , Kenneth S. Kosik
    •  & Li Gan
  • Brief Communication |

    Arc, a master regulator of synaptic plasticity, can mediate intercellular RNA transfer. Arc evolved from retrotransposon genes. Erlendsson et al. present structures of retroviral-like Arc capsids as a basis to understand their function.

    • Simon Erlendsson
    • , Dustin R. Morado
    • , Harrison B. Cullen
    • , Cedric Feschotte
    • , Jason D. Shepherd
    •  & John A. G. Briggs
  • Brief Communication |

    Maes et al. use second-order conditioning, blocking and optogenetic inhibition to show that cue-evoked dopamine transients function as temporal-difference prediction errors rather than reward predictions.

    • Etienne J. P Maes
    • , Melissa J. Sharpe
    • , Alexandra A. Usypchuk
    • , Megan Lozzi
    • , Chun Yun Chang
    • , Matthew P. H. Gardner
    • , Geoffrey Schoenbaum
    •  & Mihaela D. Iordanova

Articles

  • Article |

    Rees et al. show that de novo mutations in the gene SLC6A1, and more broadly across evolutionary constrained genes and genes implicated in neurodevelopmental disorders, increase the risk for developing schizophrenia.

    • Elliott Rees
    • , Jun Han
    • , Joanne Morgan
    • , Noa Carrera
    • , Valentina Escott-Price
    • , Andrew J. Pocklington
    • , Madeleine Duffield
    • , Lynsey S. Hall
    • , Sophie E. Legge
    • , Antonio F. Pardiñas
    • , Alexander L. Richards
    • , Julian Roth
    • , Tatyana Lezheiko
    • , Nikolay Kondratyev
    • , Vasilii Kaleda
    • , Vera Golimbet
    • , Mara Parellada
    • , Javier González-Peñas
    • , Celso Arango
    • , Behrooz Z. Alizadeh
    • , Therese van Amelsvoort
    • , Richard Bruggeman
    • , Wiepke Cahn
    • , Lieuwe de Haan
    • , Jurjen J. Luykx
    • , Bart P. F. Rutten
    • , Jim van Os
    • , Ruud van Winkel
    • , Micha Gawlik
    • , George Kirov
    • , James T. R. Walters
    • , Peter Holmans
    • , Michael C. O’Donovan
    •  & Michael J. Owen
  • Article |

    In this study of protein-coding de novo mutations in schizophrenia, researchers found only a small contribution toward overall risk, coming predominantly from genes under negative selection and highly expressed in the brain.

    • Daniel P. Howrigan
    • , Samuel A. Rose
    • , Kaitlin E. Samocha
    • , Menachem Fromer
    • , Felecia Cerrato
    • , Wei J. Chen
    • , Claire Churchhouse
    • , Kimberly Chambert
    • , Sharon D. Chandler
    • , Mark J. Daly
    • , Ashley Dumont
    • , Giulio Genovese
    • , Hai-Gwo Hwu
    • , Nan Laird
    • , Jack A. Kosmicki
    • , Jennifer L. Moran
    • , Cheryl Roe
    • , Tarjinder Singh
    • , Shi-Heng Wang
    • , Stephen V. Faraone
    • , Stephen J. Glatt
    • , Steven A. McCarroll
    • , Ming Tsuang
    •  & Benjamin M. Neale
  • Article |

    Microglia in the aging hippocampus accumulate lipid droplets, and are functionally impaired and inflamed. Lipid droplet formation in microglia is regulated by genes linked to neurodegeneration such as progranulin.

    • Julia Marschallinger
    • , Tal Iram
    • , Macy Zardeneta
    • , Song E. Lee
    • , Benoit Lehallier
    • , Michael S. Haney
    • , John V. Pluvinage
    • , Vidhu Mathur
    • , Oliver Hahn
    • , David W. Morgens
    • , Justin Kim
    • , Julia Tevini
    • , Thomas K. Felder
    • , Heimo Wolinski
    • , Carolyn R. Bertozzi
    • , Michael C. Bassik
    • , Ludwig Aigner
    •  & Tony Wyss-Coray
  • Article |

    In mice that have undergone Pavlovian reward conditioning, dopaminergic neurons regulate conditioned movements in a temporally restricted manner, consistent with a primary contribution to associative learning rather than online movement generation.

    • Kwang Lee
    • , Leslie D. Claar
    • , Ayaka Hachisuka
    • , Konstantin I. Bakhurin
    • , Jacquelyn Nguyen
    • , Jeremy M. Trott
    • , Jay L. Gill
    •  & Sotiris C. Masmanidis
  • Article |

    Gao et al. provide evidence that two major classes of neurons exist in the paraventricular thalamus. One of these, termed type II PVT neurons, belongs to a previously ignored cell population that relays arousal information to the infralimbic cortex.

    • Claire Gao
    • , Yan Leng
    • , Jun Ma
    • , Victoria Rooke
    • , Shakira Rodriguez-Gonzalez
    • , Charu Ramakrishnan
    • , Karl Deisseroth
    •  & Mario A. Penzo
  • Article |

    Shuman et al. report that epileptic mice harbor desynchronized hippocampal interneuron activity and unstable spatial representations, revealing that precise intrahippocampal synchronization is critical for spatial coding.

    • Tristan Shuman
    • , Daniel Aharoni
    • , Denise J. Cai
    • , Christopher R. Lee
    • , Spyridon Chavlis
    • , Lucia Page-Harley
    • , Lauren M. Vetere
    • , Yu Feng
    • , Chen Yi Yang
    • , Irene Mollinedo-Gajate
    • , Lingxuan Chen
    • , Zachary T. Pennington
    • , Jiannis Taxidis
    • , Sergio E. Flores
    • , Kevin Cheng
    • , Milad Javaherian
    • , Christina C. Kaba
    • , Naina Rao
    • , Mimi La-Vu
    • , Ioanna Pandi
    • , Matthew Shtrahman
    • , Konstantin I. Bakhurin
    • , Sotiris C. Masmanidis
    • , Baljit S. Khakh
    • , Panayiota Poirazi
    • , Alcino J. Silva
    •  & Peyman Golshani
  • Article |

    Munn et al. provide evidence that medial entorhinal speed signals scale to reflect the geometry of the environment, whereas entorhinal head direction signals reflect learned information about the geometric symmetry of the environment.

    • Robert G. K. Munn
    • , Caitlin S. Mallory
    • , Kiah Hardcastle
    • , Dane M. Chetkovich
    •  & Lisa M. Giocomo
  • Article |

    Yoo and colleagues find that while pursuing virtual prey, monkeys predict the prey’s upcoming movements, and neurons in the dorsal anterior cingulate cortex tracked prey position, velocity and acceleration to facilitate these predictions.

    • Seng Bum Michael Yoo
    • , Jiaxin Cindy Tu
    • , Steven T. Piantadosi
    •  & Benjamin Yost Hayden
  • Article |

    Gallego, Perich et al. report that latent dynamics in the neural manifold across three cortical areas are stable throughout years of consistent behavior. The authors posit that these dynamics are fundamental building blocks of learned behavior.

    • Juan A. Gallego
    • , Matthew G. Perich
    • , Raeed H. Chowdhury
    • , Sara A. Solla
    •  & Lee E. Miller

Resources

  • Resource |

    This resource comprises ultra-high-resolution MRI datasets and corresponding gray and white matter atlases of the marmoset brain to facilitate brain connectivity studies and the development of tractography algorithms in the primate brain.

    • Cirong Liu
    • , Frank Q. Ye
    • , John D. Newman
    • , Diego Szczupak
    • , Xiaoguang Tian
    • , Cecil Chern-Chyi Yen
    • , Piotr Majka
    • , Daniel Glen
    • , Marcello G. P. Rosa
    • , David A. Leopold
    •  & Afonso C. Silva

Technical Reports

Amendments & Corrections

  • Publisher Correction |

    • Tobias Kaufmann
    • , Dennis van der Meer
    • , Nhat Trung Doan
    • , Emanuel Schwarz
    • , Martina J. Lund
    • , Ingrid Agartz
    • , Dag Alnæs
    • , Deanna M. Barch
    • , Ramona Baur-Streubel
    • , Alessandro Bertolino
    • , Francesco Bettella
    • , Mona K. Beyer
    • , Erlend Bøen
    • , Stefan Borgwardt
    • , Christine L. Brandt
    • , Jan Buitelaar
    • , Elisabeth G. Celius
    • , Simon Cervenka
    • , Annette Conzelmann
    • , Aldo Córdova-Palomera
    • , Anders M. Dale
    • , Dominique J. F. de Quervain
    • , Pasquale Di Carlo
    • , Srdjan Djurovic
    • , Erlend S. Dørum
    • , Sarah Eisenacher
    • , Torbjørn Elvsåshagen
    • , Thomas Espeseth
    • , Helena Fatouros-Bergman
    • , Lena Flyckt
    • , Barbara Franke
    • , Oleksandr Frei
    • , Beathe Haatveit
    • , Asta K. Håberg
    • , Hanne F. Harbo
    • , Catharina A. Hartman
    • , Dirk Heslenfeld
    • , Pieter J. Hoekstra
    • , Einar A. Høgestøl
    • , Terry L. Jernigan
    • , Rune Jonassen
    • , Erik G. Jönsson
    • , Lars Farde
    • , Lena Flyckt
    • , Göran Engberg
    • , Sophie Erhardt
    • , Helena Fatouros-Bergman
    • , Simon Cervenka
    • , Lilly Schwieler
    • , Fredrik Piehl
    • , Ingrid Agartz
    • , Karin Collste
    • , Pauliina Victorsson
    • , Anna Malmqvist
    • , Mikael Hedberg
    • , Funda Orhan
    • , Peter Kirsch
    • , Iwona Kłoszewska
    • , Knut K. Kolskår
    • , Nils Inge Landrø
    • , Stephanie Le Hellard
    • , Klaus-Peter Lesch
    • , Simon Lovestone
    • , Arvid Lundervold
    • , Astri J. Lundervold
    • , Luigi A. Maglanoc
    • , Ulrik F. Malt
    • , Patrizia Mecocci
    • , Ingrid Melle
    • , Andreas Meyer-Lindenberg
    • , Torgeir Moberget
    • , Linn B. Norbom
    • , Jan Egil Nordvik
    • , Lars Nyberg
    • , Jaap Oosterlaan
    • , Marco Papalino
    • , Andreas Papassotiropoulos
    • , Paul Pauli
    • , Giulio Pergola
    • , Karin Persson
    • , Geneviève Richard
    • , Jaroslav Rokicki
    • , Anne-Marthe Sanders
    • , Geir Selbæk
    • , Alexey A. Shadrin
    • , Olav B. Smeland
    • , Hilkka Soininen
    • , Piotr Sowa
    • , Vidar M. Steen
    • , Magda Tsolaki
    • , Kristine M. Ulrichsen
    • , Bruno Vellas
    • , Lei Wang
    • , Eric Westman
    • , Georg C. Ziegler
    • , Mathias Zink
    • , Ole A. Andreassen
    •  & Lars T. Westlye
  • Publisher Correction |

    • Sali M. K. Farhan
    • , Daniel P. Howrigan
    • , Liam E. Abbott
    • , Joseph R. Klim
    • , Simon D. Topp
    • , Andrea E. Byrnes
    • , Claire Churchhouse
    • , Hemali Phatnani
    • , Bradley N. Smith
    • , Evadnie Rampersaud
    • , Gang Wu
    • , Joanne Wuu
    • , Aleksey Shatunov
    • , Alfredo Iacoangeli
    • , Ahmad Al Khleifat
    • , Daniel A. Mordes
    • , Sulagna Ghosh
    • , Kevin Eggan
    • , Rosa Rademakers
    • , Jacob L. McCauley
    • , Rebecca Schüle
    • , Stephan Züchner
    • , Michael Benatar
    • , J. Paul Taylor
    • , Michael Nalls
    • , Marc Gotkine
    • , Pamela J. Shaw
    • , Karen E. Morrison
    • , Ammar Al-Chalabi
    • , Bryan Traynor
    • , Christopher E. Shaw
    • , David B. Goldstein
    • , Matthew B. Harms
    • , Mark J. Daly
    •  & Benjamin M. Neale

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