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Volume 23 Issue 11, November 2020

Topographic organization of human subcortex

Tian and colleagues used functional MRI to unveil the extraordinarily complex layout of the human subcortex, identifying 27 new functional regions and four scales of hierarchical organization that adapt to changing cognitive demands. The cover art illustrates functional regions of the human subcortex delineated at Scale I (left) and Scale IV (right).

See Tian et al.

Image: Ye Tian. Cover design: Marina Corral Spence.

News & Views

  • Chiot and colleagues investigated whether peripheral macrophages play a role in amyotrophic lateral sclerosis (ALS) pathology, finding that macrophages along peripheral motor neuron axons react to neurodegeneration. Modifying reactive oxygen species (ROS) signaling in peripheral macrophages, using bone marrow cell replacement, reduces both macrophage and microglia inflammatory response, delays pathology and increases survival in ALS mouse models.

    • P. Hande Özdinler
    News & Views


  • Abrupt spatial changes in anatomic and functional properties of the brain demarcate boundaries between discrete functional areas. While previous work has identified these boundaries in cortex, a new study by Tian et al. applies this approach for the first time to subcortical structures within the in vivo human brain.

    • Evan M. Gordon
    News & Views
  • By building a richer behavioral vocabulary, Wiltschko et al. tease apart subtle differences in how pharmacological agents affect animal behavior, mapping on- and off-target effects of drugs with improved precision.

    • Ann Kennedy
    News & Views
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Review Articles

  • Aggression is an instinctive behavior supported by hardwired neural circuits. Julieta Lischinsky and Dayu Lin review our current understanding of the neural circuits of aggression across species and their modulation by internal state.

    • Julieta E. Lischinsky
    • Dayu Lin
    Review Article
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  • By analyzing hundreds of mice treated with a library of neuro- and psychoactive drugs, Wiltschko et al. show that Motion Sequencing can effectively discriminate and categorize drug effects and link molecular targets to behavioral syllables.

    • Alexander B. Wiltschko
    • Tatsuya Tsukahara
    • Sandeep Robert Datta
  • The ventral hippocampus is central in the processing of emotional information. Here, a combination of viral and sequencing approaches defines the organizational logic of the extended ventral CA1 circuit.

    • Mark M. Gergues
    • Kasey J. Han
    • Mazen A. Kheirbek
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Amendments & Corrections

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