Volume 22 Issue 3, March 2019

Volume 22 Issue 3

Driving CA1

Hippocampal circuitry enables the emergence of activity patterns that are crucial for spatial learning and memory. Davoudi and Foster used acute optogenetic silencing to reveal the dominant role of hippocampal area CA3 in driving place cell activity in hippocampal area CA1 at the single-cell and neural population levels. The cover image represents CA3 neurons activating CA1 place cells through their axons, the Schaffer collaterals.

See Davoudi and Foster

Image: Zeinab Vessal. Cover Design: Marina Corral Spence.

News & Views

  • News & Views |

    Variability is a ubiquitous aspect of neural recordings. In an influential paper, Churchland et al. (2010) compiled data from many cortical areas to demonstrate that variability generally decreases upon presentation of a stimulus. What are the implications of this finding?

    • Adrienne L. Fairhall
  • News & Views |

    Geneticists are pushing for ever-greater sample sizes to gain insight into the genetic variation that contributes to psychiatric disorders. Two new genome-wide association studies leverage this approach to provide broad, population-level perspectives on the genetic basis for major depressive disorder and the shared genetic risk that underlies multiple disorders.

    • Lea Karatheodoris Davis
  • News & Views |

    Excessive synapse elimination during adolescence and early adulthood has long been hypothesized to underpin the emergence of schizophrenia. A new study reports that induced microglia-like cells derived from schizophrenia patients display increased synapse engulfment, which may be partly mediated by a genetic schizophrenia-risk variant.

    • Meiyan Wang
    • , Lei Zhang
    •  & Fred H. Gage
  • News & Views |

    Disproportionate reactions to unexpected stimuli and greater attention to perceived threat are cardinal symptoms of post-traumatic stress disorder. Computational psychiatry helps explain how these responses develop and result from abnormalities in learning and prediction during and after traumatic events.

    • Peggy Seriès

Brief Communications

Articles

  • Article |

    The authors conducted a genetic meta-analysis of depression and found 269 associated genes. These genes highlight several potential drug repositioning opportunities, and relationships with depression were found for neuroticism and smoking.

    • David M. Howard
    • , Mark J. Adams
    • , Toni-Kim Clarke
    • , Jonathan D. Hafferty
    • , Jude Gibson
    • , Masoud Shirali
    • , Jonathan R. I. Coleman
    • , Saskia P. Hagenaars
    • , Joey Ward
    • , Eleanor M. Wigmore
    • , Clara Alloza
    • , Xueyi Shen
    • , Miruna C. Barbu
    • , Eileen Y. Xu
    • , Heather C. Whalley
    • , Riccardo E. Marioni
    • , David J. Porteous
    • , Gail Davies
    • , Ian J. Deary
    • , Gibran Hemani
    • , Klaus Berger
    • , Henning Teismann
    • , Rajesh Rawal
    • , Volker Arolt
    • , Bernhard T. Baune
    • , Udo Dannlowski
    • , Katharina Domschke
    • , Chao Tian
    • , David A. Hinds
    • , Maciej Trzaskowski
    • , Enda M. Byrne
    • , Stephan Ripke
    • , Daniel J. Smith
    • , Patrick F. Sullivan
    • , Naomi R. Wray
    • , Gerome Breen
    • , Cathryn M. Lewis
    •  & Andrew M. McIntosh
  • Article |

    Schork et al. identify novel variants contributing to shared risk among psychiatric disorders and suggest that these variants act through the disruption of early neurodevelopment.

    • Andrew J. Schork
    • , Hyejung Won
    • , Vivek Appadurai
    • , Ron Nudel
    • , Mike Gandal
    • , Olivier Delaneau
    • , Malene Revsbech Christiansen
    • , David M. Hougaard
    • , Marie Bækved-Hansen
    • , Jonas Bybjerg-Grauholm
    • , Marianne Giørtz Pedersen
    • , Esben Agerbo
    • , Carsten Bøcker Pedersen
    • , Benjamin M. Neale
    • , Mark J. Daly
    • , Naomi R. Wray
    • , Merete Nordentoft
    • , Ole Mors
    • , Anders D. Børglum
    • , Preben Bo Mortensen
    • , Alfonso Buil
    • , Wesley K. Thompson
    • , Daniel H. Geschwind
    •  & Thomas Werge
  • Article |

    An interaction between UTX and 53BP1, which occurs in humans but not mice, promotes neurogenic gene expression that underlies neuronal differentiation and cortical development, perhaps providing insight into human-specific neurodevelopment.

    • Xiaoyang Yang
    • , Beisi Xu
    • , Brett Mulvey
    • , Myron Evans
    • , Samuel Jordan
    • , Yong-Dong Wang
    • , Vishwajeeth Pagala
    • , Junmin Peng
    • , Yiping Fan
    • , Arishna Patel
    •  & Jamy C. Peng
  • Article |

    Postmortem studies indicate reduced synaptic density in schizophrenia. Sellgren et al. show increased synaptic pruning in patient-derived cell models and provide evidence that C4 risk variants increase engulfment, while minocycline decreases it.

    • Carl M. Sellgren
    • , Jessica Gracias
    • , Bradley Watmuff
    • , Jonathan D. Biag
    • , Jessica M. Thanos
    • , Paul B. Whittredge
    • , Ting Fu
    • , Kathleen Worringer
    • , Hannah E. Brown
    • , Jennifer Wang
    • , Ajamete Kaykas
    • , Rakesh Karmacharya
    • , Carleton P. Goold
    • , Steven D. Sheridan
    •  & Roy H. Perlis
  • Article |

    Shen et al. show that FMRP promotes mitochondrial fusion through HTT. FMRP loss caused fragmented mitochondria and oxidative stress in immature neurons, and enhancing mitochondrial fusion rescued neuronal and behavioral deficits in Fmr1-mutant mice.

    • Minjie Shen
    • , Feifei Wang
    • , Meng Li
    • , Nirnath Sah
    • , Michael E. Stockton
    • , Joseph J. Tidei
    • , Yu Gao
    • , Tomer Korabelnikov
    • , Sudharsan Kannan
    • , Jason D. Vevea
    • , Edwin R. Chapman
    • , Anita Bhattacharyya
    • , Henriette van Praag
    •  & Xinyu Zhao
  • Article |

    The authors report that mitophagy is impaired in Alzheimer’s disease. Stimulation of mitophagy reverses cognitive deficits in nematode and mouse models of Alzheimer’s disease, suggesting a potential therapeutic intervention.

    • Evandro F. Fang
    • , Yujun Hou
    • , Konstantinos Palikaras
    • , Bryan A. Adriaanse
    • , Jesse S. Kerr
    • , Beimeng Yang
    • , Sofie Lautrup
    • , Md Mahdi Hasan-Olive
    • , Domenica Caponio
    • , Xiuli Dan
    • , Paula Rocktäschel
    • , Deborah L. Croteau
    • , Mansour Akbari
    • , Nigel H. Greig
    • , Tormod Fladby
    • , Hilde Nilsen
    • , M. Zameel Cader
    • , Mark P. Mattson
    • , Nektarios Tavernarakis
    •  & Vilhelm A. Bohr
  • Article |

    The authors found that white blood cells plug about 2% of capillaries in the brains of Alzheimer’s disease mouse models. When the adhesion of these cells was blocked, cerebral blood flow immediately increased and cognitive performance rapidly improved.

    • Jean C. Cruz Hernández
    • , Oliver Bracko
    • , Calvin J. Kersbergen
    • , Victorine Muse
    • , Mohammad Haft-Javaherian
    • , Maxime Berg
    • , Laibaik Park
    • , Lindsay K. Vinarcsik
    • , Iryna Ivasyk
    • , Daniel A. Rivera
    • , Yiming Kang
    • , Marta Cortes-Canteli
    • , Myriam Peyrounette
    • , Vincent Doyeux
    • , Amy Smith
    • , Joan Zhou
    • , Gabriel Otte
    • , Jeffrey D. Beverly
    • , Elizabeth Davenport
    • , Yohan Davit
    • , Charles P. Lin
    • , Sidney Strickland
    • , Costantino Iadecola
    • , Sylvie Lorthois
    • , Nozomi Nishimura
    •  & Chris B. Schaffer
  • Article |

    Blood vessels help macrophage entry. Zhou et al. show that activated microvessels serve as critical portals for macrophage entry to boost inflammation after spinal cord injury.

    • Tian Zhou
    • , Yiming Zheng
    • , Li Sun
    • , Smaranda Ruxandra Badea
    • , Yuanhu Jin
    • , Yang Liu
    • , Alyssa J. Rolfe
    • , Haitao Sun
    • , Xi Wang
    • , Zhijian Cheng
    • , Zhaoshuai Huang
    • , Na Zhao
    • , Xin Sun
    • , Jinhua Li
    • , Jianqing Fan
    • , Choogon Lee
    • , Timothy L. Megraw
    • , Wutian Wu
    • , Guixue Wang
    •  & Yi Ren
  • Article |

    Besnard et al. uncover functional heterogeneity of somatostatin interneurons (SST-INs) in the dorsolateral septum and reveal a role for a subpopulation of SST-INs as hippocampal relays that govern mobility to calibrate adaptive fear responses.

    • Antoine Besnard
    • , Yuan Gao
    • , Michael TaeWoo Kim
    • , Hannah Twarkowski
    • , Alexander Keith Reed
    • , Tomer Langberg
    • , Wendy Feng
    • , Xiangmin Xu
    • , Dieter Saur
    • , Larry S. Zweifel
    • , Ian Davison
    •  & Amar Sahay
  • Article |

    Neuronal responses in a higher-order auditory cortical area reveal striking attention-driven effects, long-term learning, and stimulus–action coupling, indicating a dynamic intermediate stage between sensory and frontal cortex representations.

    • Diego Elgueda
    • , Daniel Duque
    • , Susanne Radtke-Schuller
    • , Pingbo Yin
    • , Stephen V. David
    • , Shihab A. Shamma
    •  & Jonathan B. Fritz
  • Article |

    DeNardo et al. characterize TRAP2, which allows genetic access to neurons based on their activity, and use it to show that neuronal ensembles in prelimbic cortex for remote fear memory undergo dynamic changes during the first 14 days after learning.

    • Laura A. DeNardo
    • , Cindy D. Liu
    • , William E. Allen
    • , Eliza L. Adams
    • , Drew Friedmann
    • , Lisa Fu
    • , Casey J. Guenthner
    • , Marc Tessier-Lavigne
    •  & Liqun Luo
  • Article |

    PTSD symptom severity in combat veterans was associated with enhanced sensitivity to prediction errors and lower neural tracking of value and learning rate, providing evidence for neurocomputational contributions to trauma-related psychopathology.

    • Philipp Homan
    • , Ifat Levy
    • , Eric Feltham
    • , Charles Gordon
    • , Jingchu Hu
    • , Jian Li
    • , Robert H. Pietrzak
    • , Steven Southwick
    • , John H. Krystal
    • , Ilan Harpaz-Rotem
    •  & Daniela Schiller
  • Article |

    van Ede et al. show that both sensory qualities and motor responses associated with information held in mind are accessed simultaneously to guide behavior. The findings help bridge the fields of visual working memory and action planning.

    • Freek van Ede
    • , Sammi R. Chekroud
    • , Mark G. Stokes
    •  & Anna C. Nobre

Technical Reports

Amendments & Corrections