Volume 22 Issue 1, January 2019

Volume 22 Issue 1

Glioma cell–white matter invasion

Glioma cell invasion and migration along white matter tracts is thought to be one of the main causes of poor therapeutic outcome in malignant glioma. Yu and colleagues investigate the underlying signaling pathways, finding CD133+Notch1+ glioma stem cells (pink cells) are recruited to Jagged1+ white matter tracts (green) via a NOTCH1–SOX2 positive-feedback loop.

See Wang et al.

Image credit: Shicang Yu. Cover design: Marina Corral Spence.

News & Views

  • News & Views |

    In 2010, Johnson and Kenny provided conclusive evidence that extended access to a Western-style diet promotes addictive-like behavior in rats by downregulating D2 receptors while promoting obesity. This focused attention on the parallels between drug addiction and overeating and fueled a decade of food addiction research.

    • Alexandra G. DiFeliceantonio
    •  & Dana M. Small
  • News & Views |

    TDP-43 forms cytoplasmic aggregates in degenerating neurons of frontotemporal dementia (FTD) patients. Laferrière et al. now establish that TDP-43 assemblies from distinct FTD subtypes have different structures, neurotoxicities, and seeding activities, which correlate with FTD severity. Thus, distinct pathological TDP-43 assemblies akin to prion strains might underpin distinct FTD subtypes.

    • Edward M. Barbieri
    •  & James Shorter
  • News & Views |

    The locus coeruleus is known to be an essential source of neuromodulation that influences sensory processing, including the enhancement of feature selectivity associated with attentional focus. A new study shows that the primary sensory thalamus encompasses one circuit that underlies this enhancement.

    • Tingting Zhou
    •  & Michael M Halassa

Review Articles

  • Review Article |

    Knowledge of the role of glial–neuronal interactions in the physiology of food intake and energy metabolism is emerging. This review highlights the role of astrocytes, microglia, and tanycytes in central control of systemic metabolism.

    • Cristina García-Cáceres
    • , Eglantine Balland
    • , Vincent Prevot
    • , Serge Luquet
    • , Stephen C. Woods
    • , Marco Koch
    • , Tamas L. Horvath
    • , Chun-Xia Yi
    • , Julia A. Chowen
    • , Alexei Verkhratsky
    • , Alfonso Araque
    • , Ingo Bechmann
    •  & Matthias H. Tschöp
  • Review Article |

    A satisfactory understanding of how natural stimuli are encoded by neural circuits has remained elusive. Advances in machine learning provide new approaches to this problem by merging constraints imposed by stimulus statistics and behavioral goals.

    • Maxwell H. Turner
    • , Luis Gonzalo Sanchez Giraldo
    • , Odelia Schwartz
    •  & Fred Rieke

Articles

  • Article |

    An overall downregulation of RNA editing was observed in postmortem brains from people with autism, which was consistent across brain regions and genetic disorder subtypes. These changes were regulated by the RNA-binding proteins FMRP and FXR1P.

    • Stephen S. Tran
    • , Hyun-Ik Jun
    • , Jae Hoon Bahn
    • , Adel Azghadi
    • , Gokul Ramaswami
    • , Eric L. Van Nostrand
    • , Thai B. Nguyen
    • , Yun-Hua E. Hsiao
    • , Changhoon Lee
    • , Gabriel A. Pratt
    • , Verónica Martínez-Cerdeño
    • , Randi J. Hagerman
    • , Gene W. Yeo
    • , Daniel H. Geschwind
    •  & Xinshu Xiao
  • Article |

    Tau but not amyloid-beta pathology is associated with widespread alterations of histone 3 lysine 9 acetylation in the aged human cortex. Similar alterations of chromatin organization occur in iPSC-derived neurons after overexpression of tau.

    • Hans-Ulrich Klein
    • , Cristin McCabe
    • , Elizabeta Gjoneska
    • , Sarah E. Sullivan
    • , Belinda J. Kaskow
    • , Anna Tang
    • , Robert V. Smith
    • , Jishu Xu
    • , Andreas R. Pfenning
    • , Bradley E. Bernstein
    • , Alexander Meissner
    • , Julie A. Schneider
    • , Sara Mostafavi
    • , Li-Huei Tsai
    • , Tracy L. Young-Pearse
    • , David A. Bennett
    •  & Philip L. De Jager
  • Article |

    Neuron types vulnerable to tau accumulation (excitatory neurons) in AD brain are intrinsically less able to maintain tau homeostasis than neuron types that are resistant (inhibitory neurons).

    • Hongjun Fu
    • , Andrea Possenti
    • , Rosie Freer
    • , Yoshikazu Nakano
    • , Nancy C. Hernandez Villegas
    • , Maoping Tang
    • , Paula V. M. Cauhy
    • , Benjamin A. Lassus
    • , Shuo Chen
    • , Stephanie L. Fowler
    • , Helen Y. Figueroa
    • , Edward D. Huey
    • , Gail V. W. Johnson
    • , Michele Vendruscolo
    •  & Karen E. Duff
  • Article |

    Microscopic imaging of neurons in mouse models of Alzheimer’s disease shows that plaques increase activity while neurofibrillary tangles suppress activity. The combination of plaques and tangles, as in humans with Alzheimer’s disease, suppresses activity.

    • Marc Aurel Busche
    • , Susanne Wegmann
    • , Simon Dujardin
    • , Caitlin Commins
    • , Julia Schiantarelli
    • , Naomi Klickstein
    • , Tarun V. Kamath
    • , George A. Carlson
    • , Israel Nelken
    •  & Bradley T. Hyman
  • Article |

    Using a newly developed biochemical method for aggregated protein extraction, Laferrière and colleagues uncover different neurotoxic types of pathologic TDP-43 assemblies in the brains of subjects with distinct subtypes of frontotemporal dementia.

    • Florent Laferrière
    • , Zuzanna Maniecka
    • , Manuela Pérez-Berlanga
    • , Marian Hruska-Plochan
    • , Larissa Gilhespy
    • , Eva-Maria Hock
    • , Ulrich Wagner
    • , Tariq Afroz
    • , Paul J. Boersema
    • , Gery Barmettler
    • , Sandrine C. Foti
    • , Yasmine T. Asi
    • , Adrian M. Isaacs
    • , Ashraf Al-Amoudi
    • , Amanda Lewis
    • , Henning Stahlberg
    • , John Ravits
    • , Francesca De Giorgi
    • , François Ichas
    • , Erwan Bezard
    • , Paola Picotti
    • , Tammaryn Lashley
    •  & Magdalini Polymenidou
  • Article |

    Single-cell mass cytometry was applied to comprehensively characterize postmortem and fresh human microglia. Using a hybrid workflow for multidimensional data analysis, a core signature and regional heterogeneity were identified.

    • Chotima Böttcher
    • , Stephan Schlickeiser
    • , Marjolein A. M. Sneeboer
    • , Desiree Kunkel
    • , Anniki Knop
    • , Evdokia Paza
    • , Pawel Fidzinski
    • , Larissa Kraus
    • , Gijsje J. L. Snijders
    • , René S Kahn
    • , Axel R Schulz
    • , Henrik E Mei
    • , Elly M. Hol
    • , Britta Siegmund
    • , Rainer Glauben
    • , Eike J Spruth
    • , Lot D de Witte
    •  & Josef Priller
  • Article |

    CD133 and Notch1 double-positive GSCs were preferentially located along Jagged1-expressing white matter tracts, which exhibited a demyelinated phenotype. The NOTCH1SOX9SOX2 positive-feedback loop controls GSC invasion along white matter tracts.

    • Jun Wang
    • , Sen-Lin Xu
    • , Jiang-Jie Duan
    • , Liang Yi
    • , Yu-Feng Guo
    • , Yu Shi
    • , Lin Li
    • , Ze-Yu Yang
    • , Xue-Mei Liao
    • , Jiao Cai
    • , Yan-Qi Zhang
    • , Hua-Liang Xiao
    • , Li Yin
    • , Hao Wu
    • , Jing-Na Zhang
    • , Sheng-Qing Lv
    • , Qing-Kai Yang
    • , Xiao-Jun Yang
    • , Tao Jiang
    • , Xia Zhang
    • , Xiu-Wu Bian
    •  & Shi-Cang Yu
  • Article |

    Yu, Li et al. show that VTA GABA and glutamate neurons induce sleep and waking, respectively, via projections to the lateral hypothalamus and nucleus accumbens. Thus, in addition to influencing reward-directed behaviors, the VTA regulates arousal.

    • Xiao Yu
    • , Wen Li
    • , Ying Ma
    • , Kyoko Tossell
    • , Julia J. Harris
    • , Edward C. Harding
    • , Wei Ba
    • , Giulia Miracca
    • , Dan Wang
    • , Long Li
    • , Juan Guo
    • , Ming Chen
    • , Yuqi Li
    • , Raquel Yustos
    • , Alexei L. Vyssotski
    • , Denis Burdakov
    • , Qianzi Yang
    • , Hailong Dong
    • , Nicholas P. Franks
    •  & William Wisden
  • Article |

    Polanía et al. show that, similarly to sensory signals, subjective preferences guiding choice are represented by the brain in a manner that accounts for regularities of the environment, thereby optimizing use of limited neural processing resources.

    • Rafael Polanía
    • , Michael Woodford
    •  & Christian C. Ruff

Amendments & Corrections