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Volume 22 Issue 12, December 2019

Volume 22 Issue 12

Trace cells in human entorhinal cortex

Episodic memory requires binding of memory content with the context in which the memory was experienced. In this issue, Qasim et al. report on how this process might be supported by specific cells in the human medial temporal lobe. In particular, they find memory-trace cells in the entorhinal cortex that, in a spatial memory task, encode the location that subjects associate with the specific memory they are required to retrieve. The cover art depicts a pool of water representing all of a person’s memories. That person is seen reaching towards a particular memory that is bound to its spatial context, characterized here by buildings, objects and landmarks arranged in space.

See Qasim et al.

Image credit: Jasu Hu. Cover design: Marina Corral Spence

News & Views

  • News & Views |

    Behavior is more than the motor outputs that we can directly measure. Here Calhoun and colleagues devise a novel method for inferring the internal states that affect how fruit flies process sensory information during courtship, providing a new framework for understanding the neural encoding of behavior.

    • Kanishk Jain
    • Gordon J. Berman
  • News & Views |

    Reitich-Stolero and Paz examined multineuron correlates of Pavlovian learning in the primate amygdala. They found repeating patterns of activity across neurons that may mediate synaptic-level plasticity mechanisms. This extends the notion of replay, often examined relative to navigation in the hippocampus, to aversive learning in the amygdala.

    • Bruno B. Averbeck

Review Articles

  • Review Article |

    Malignant gliomas recapitulate steps in neurodevelopment to form organ-like structures. Jung et al. review how neuroscience can provide novel insights into glioma biology, and how these insights might be used for future therapeutic approaches.

    • Erik Jung
    • Julieta Alfonso
    • Frank Winkler



Technical Reports

Amendments & Corrections


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