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Volume 21 Issue 5, May 2018

Volume 21 Issue 5

Locomotion modulates associative learning

Albergaria, Carey and colleagues show that locomotor activity improves associative learning in mice through mechanisms that act on the mossy fiber pathway within the cerebellum. The cover image incorporates references to Pavlov’s original classical conditioning experiments, within a cerebellar landscape.

See Albergaria et al.

Image: Gil Costa. Cover Design: Erin Dewalt.

Editorial

News & Views

  • News & Views |

    The behavioral state of a human or animal can dramatically alter how information is processed in its neural circuits. Albergaria et al. show that locomotion enhances the performance of a cerebellum-dependent behavior. The results provide new constraints on how information is represented there to support learning.

    • Jennifer L. Raymond
  • News & Views |

    Recurring bursts of thalamocortical cells were thought to be indispensable in driving absence seizures. A new study demonstrates that bursts from inhibitory thalamic reticular neurons are crucial instead. Reticular bursts are driven by cortical inputs and govern precise timing of thalamocortical cell activity during seizures.

    • László Acsády
  • News & Views |

    Epidemiology and animal research have shown that the offspring of mothers who experience inflammation during pregnancy are at increased risk for psychopathology. A human study links a mother’s inflammation during pregnancy to her newborn’s functional brain organization and the child’s working memory two years later.

    • Monica D. Rosenberg

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