Volume 21 Issue 3, March 2018

Volume 21 Issue 3

A circuit for object exploration

Kim and colleagues discovered a medial preoptic circuit involved in mediating behavioral responses toward nonsocial objects and prey.

See Park et al. 21, 364–372 (2018)

Image: Photograph by Yoon-Jung Nam. Cover Design: Erin Dewalt.

News & Views

  • News & Views |

    Direct conversion of adult Huntington’s disease patient fibroblasts into medium spiny neurons recapitulates hallmark phenotypes such as cell death, in contrast to models that lack epigenetic markers of aging. This successful ‘disease-in-a-dish’ highlights the benefits of capturing age in an adult-onset disorder model.

    • Virginia B. Mattis
    •  & Clive N. Svendsen

    Nature Outlook:

  • News & Views |

    Using a series of functional manipulation and in vivo recording tools, Park et al. identify a pathway from medial preoptic CaMKIIα-expressing neurons to the ventral periaqueductal gray that mediates object craving and prey hunting.

    • Dayu Lin
  • News & Views |

    Humans and animals can react to the affective state of others in distress. However, exposure to a stressed partner can trigger stress-related adaptations. Two studies shed light on the mechanisms underlying the behavioral responses toward stressed individuals and on the synaptic changes associated with social transmission of stress.

    • Dana Rubi Levy
    •  & Ofer Yizhar
  • News & Views |

    The human brain shows regional selective vulnerability to the pathology of Alzheimer’s disease. Jacobs et al. show that the protein amyloid-β promotes the spread of tau through specific components of a neural system underlying memory formation, thus leading to the prominent early symptom of amnesia.

    • William Jagust

Perspectives

Brief Communications

  • Brief Communication |

    The authors show that Mrgprs, vagal sensory neuron-expressing GPCRs, mediate bronchoconstriction and hyperresponsiveness, both of which are hallmark features of asthma. The results reveal novel potential neural mechanisms underlying asthma.

    • Liang Han
    • , Nathachit Limjunyawong
    • , Fei Ru
    • , Zhe Li
    • , Olivia J. Hall
    • , Haley Steele
    • , Yuyan Zhu
    • , Julie Wilson
    • , Wayne Mitzner
    • , Marian Kollarik
    • , Bradley J. Undem
    • , Brendan J. Canning
    •  & Xinzhong Dong

Articles

Technical Reports

  • Technical Report |

    This study describes single-nucleus ATAC-seq, a method to profile open chromatin in individual nuclei from frozen tissues. It is used to examine gene regulation in 15,000 nuclei comprising 20 distinct cell types in the developing mouse forebrain.

    • Sebastian Preissl
    • , Rongxin Fang
    • , Hui Huang
    • , Yuan Zhao
    • , Ramya Raviram
    • , David U. Gorkin
    • , Yanxiao Zhang
    • , Brandon C. Sos
    • , Veena Afzal
    • , Diane E. Dickel
    • , Samantha Kuan
    • , Axel Visel
    • , Len A. Pennacchio
    • , Kun Zhang
    •  & Bing Ren
  • Technical Report |

    dCas9-mediated activation has been verified and widely used in vitro. Here the authors generated a potent in vivo activation platform and applied it to control the transcription of multiple genetic elements in the mammalian brain.

    • Haibo Zhou
    • , Junlai Liu
    • , Changyang Zhou
    • , Ni Gao
    • , Zhiping Rao
    • , He Li
    • , Xinde Hu
    • , Changlin Li
    • , Xuan Yao
    • , Xiaowen Shen
    • , Yidi Sun
    • , Yu Wei
    • , Fei Liu
    • , Wenqin Ying
    • , Junming Zhang
    • , Cheng Tang
    • , Xu Zhang
    • , Huatai Xu
    • , Linyu Shi
    • , Leping Cheng
    • , Pengyu Huang
    •  & Hui Yang
  • Technical Report |

    CRISPR interference-based gene silencing was adopted to achieve highly efficient multiple and conditional gene knockdown in the mouse brain with negligible off-target effects, providing a rapid gene interrogation tool in the mammalian brain.

    • Yi Zheng
    • , Wei Shen
    • , Jian Zhang
    • , Bo Yang
    • , Yao-Nan Liu
    • , Huihui Qi
    • , Xia Yu
    • , Si-Yao Lu
    • , Yun Chen
    • , Yu-Zhou Xu
    • , Yun Li
    • , Fred H. Gage
    • , Shuangli Mi
    •  & Jun Yao

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